A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem

Thank you so much, Steve!

Excited to see this work out as a preprint!

Proud to be part of this incredible international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine.

This journey started ~7 years ago, and it’s been amazing!

Molecular Structures of the Hearing Loss Associated Human P2X2 Receptor ATP is best known as the “fuel of the cell,” providing energy for nearly every biological process. But when ATP is released from cells, it takes on a very different role — acting as a danger signal th...

link.growkudos.com/1eub610y1hc

Thank you. It’s great to see and hear about all the different types of science being done in the KCVI.

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:

urldefense.com/v3/__https:/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social

A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.

A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.

@volluminstitute.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! Read the full article: bit.ly/4b9gOw9

An individual in a blue shirt and sweatshirt stands in front of a machine with the words "Titan Krios" on the side.

@ohsunews.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! news.ohsu.edu/2025/06/23/o...

The KCVI research retreat was a great success this year.

Very happy to participate. Looking forward to making this an annual event!

March 27, 2025: Adam Oken, Oregon Health and Sciences University YouTube video by CryoEM Service Centers

Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.

If you are interested, please watch a recording of his seminar, linked here:

youtu.be/IdcoLJc7X8M

The Changemakers: Steven E. Mansoor, M.D., Ph.D. | OHSU Foundation Cardiologist and physician-scientist Steven Mansoor, M.D., Ph.D., is researching new drugs to fight a variety of medical conditions.

Navigating the worlds of research and patient care requires both precision and passion, and @ohsunews.bsky.social's Dr. Steven E. Mansoor finds fulfillment in this work as a physician-scientist. ohsufoundation.org/stories/the-...

This is such a great course taught by incredible scientists!

A paper from our group published a couple of months ago.

I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.