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Posts by Javier E. Fernandez

Grateful to colleagues, mentors, and collaborators for the trust, discussions, and shared problem-solving over the years.

Looking ahead to new challenges and opportunities, and excited to keep building and collaborating.

#Bioinformatics #Genomics #CareerTransition #timetomoveon

3 months ago 2 0 0 0

After 7 years, I’m saying goodbye to the lab that shaped a big part of my scientific journey.

I earned here my PhD in Genomics & Bioinformatics, publishing research and building the lab’s bioinformatics pipelines from the ground up. A challenging and very rewarding experience.

3 months ago 10 1 1 0
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After the great plasmids evolution session in the morning I followed up on the topic with my poster. Very nice discussions with colleagues that passed by to check it. Enjoyed it very much πŸ™

#ESCMIDGlobal #genomics #bioinformatics #AMR #OneHealth

1 year ago 15 0 0 0

Interested in a snapshot of plasmids phylogeny and AMR? Come get a look at poster P1864 today and let’s chat!

#ESCMIDGlobal #genomics #bioinformatics #plasmids #AMR

1 year ago 6 0 0 0
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Ready for #ESCMID2025, looking forward to meeting colleagues and hearing about recent developments on the field!
#InfectiousDiseases #Microbiology #ESCMID #OneHealth
#GlobalHealth #ESCMIDGlobal

1 year ago 12 0 1 0
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Genetics, ecology and evolution of phage satellites Nature Reviews Microbiology - In this Review, PenadΓ©s et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the...

If you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs! rdcu.be/efkvG

1 year ago 53 19 0 0
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JUNIPER: Reconstructing Transmission Events from Next-Generation Sequencing Data at Scale Transmission reconstruction--the inference of who infects whom in disease outbreaks--offers critical insights into how pathogens spread and provides opportunities for targeted control measures. We dev...

We present JUNIPER, our outbreak reconstruction tool that incorporates within-host variants, models missing data, and scales to large, sparsely sampled datasets to achieve state-of-the-art performance. Led by @ivan_specht et al. @sabeti_lab. www.medrxiv.org/content/10.1... 1/12 🧡

1 year ago 27 16 1 1
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Diversification of bla OXA-48-harbouring plasmids among carbapenemase-producing Enterobacterales, 11 years after a large outbreak in a general hospital in the Netherlands Introduction. Genes encoding OXA-48-like carbapenem-hydrolyzing enzymes are often located on plasmids and are abundant among carbapenemase-producing Enterobacterales (CPE) worldwide. After a large bla...

Diversification of blaOXA-48-harbouring plasmids among carbapenemase-producing Enterobacterales, 11 years after a large outbreak in a general hospital in the Netherlands www.microbiologyresearch.org/content/jour...

1 year ago 3 1 0 0
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Global phylogenomic analysis of Staphylococcus pseudintermedius reveals genomic and prophage diversity in multidrug-resistant lineages Staphylococcus pseudintermedius is the foremost cause of opportunistic canine skin and mucosal infections worldwide. Multidrug-resistant (MDR) and methicillin-resistant Staphylococcus pseudintermedius...

www.microbiologyresearch.org/content/jour...
We got a new paper out on Staphylococcus pseudintermedius genomics, led by @jaimehat.bsky.social from @uniofsurrey.bsky.social with Fitzpatrick referrals.

1 year ago 7 1 0 0

We've released our lecture notes for the course Probabilistic AI at ETH Zurich, covering uncertainty in ML and its importance for sequential decision making. Thanks a lot to @jonhue.bsky.social for his amazing effort and to everyone who contributed! We hope this resource is useful to you!

1 year ago 61 10 1 0
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Snippy: Microbial Variant Calling Community Survey Help us drive the next wave of innovation in Single-Nucleotide Polymorphism (SNP) discovery and genome analysis by sharing your valuable experiences and insights. This in-depth survey aims at understa...

πŸ¦˜βœ‚οΈ Thanks to @cziscience.bsky.social , @wytamma.bsky.social and I are writing the next version of the Snippy bacterial variant calling pipeline. We want your input on what features s it will have. Please fill out this (longish) survey to help make Snippy great again!
forms.gle/YJP6WQjsk8KK...

1 year ago 58 41 3 1
Europe PMCHome - Europe PMC Europe PMC is an archive of life sciences journal literature.

As we can expect PubMed dysfunction more and more or to be swamped with fake journals I suggest you get acquainted to this nice alternative: europepmc.org

1 year ago 427 156 11 8
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Enjoying and learning a lot from this piece! I don’t know if the best reading choice for a week of holiday 🀣🀯 but 100% recommended if you are like me still getting your head around TDL/GDL.
@mathildepapillon.bsky.social and co-authors πŸ™ŒπŸ‘

arxiv.org/pdf/2407.09468

1 year ago 12 4 0 1
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Our paper describing mettannotator, a new prokaryotic annotation pipeline, is out: academic.oup.com/bioinformati...
πŸ“ Mettannotator generates comprehensive structural & functional annotations
βš™οΈ Built with #Nextflow β€” scalable, no installation needed

1 year ago 12 6 1 0
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Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy Plasmids are a ubiquitous feature of bacterial genomes, but the evolutionary forces driving genes to become associated with plasmids are poorly understood. To address this problem, we compared the fit...

New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time.
www.biorxiv.org/content/10.1...

1 year ago 127 68 6 0
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🀯 learning so much from this piece!
Highly recommended!!
#GDL

maurice-weiler.gitlab.io#cnn_book

1 year ago 1 0 0 0
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getphylo: rapid and automatic generation of multi-locus phylogenetic trees - BMC Bioinformatics Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...

getphylo is finally official! Build phylogenetic trees directly from genbank files - at breakneck speed! I'd like to thank everyone who provided feedback and encourage you to continue. Improving getphylo doesn't stop now the paper is out!
1/5
πŸ§ͺ
bmcbioinformatics.biomedcentral.com/articles/10....

1 year ago 28 13 2 0

Nice to read this today! I had to decide if going for a softer core or not, and luckily I made the right choice πŸ˜…πŸ‘Œ #mustread

1 year ago 1 0 0 0
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High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations - Nature Communications Resistance mutations are challenging to characterize because their effects are highly context dependent. Here, authors present a quantitative mutant screening technique that deconstructs how factors l...

Very excited that my 1st first-author paper has just been published!! We present a novel mutant screening technique that can rapidly identify 100s of antibiotic resistance mutations, while evaluating how likely they are in different genetic backgrounds.

www.nature.com/articles/s41...

1 year ago 49 15 2 2
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Graph Transformers (GTs) can handle long-range dependencies and resolve information bottlenecks, but they’re computationally expensive. Our new model, Spexphormer, helps scale them to much larger graphs – check it out at NeurIPS next week, or the preview here!
[1/13]
#NeurIPS2024

1 year ago 65 14 1 1

Two deadlines coming up in the next few weeks!

1 year ago 4 7 0 0
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Pre-print alert:
Extracellular Vesicles of Minimalistic Mollicutes as Mediators of Immune Modulation and Horizontal Gene Transfer

www.researchsquare.com/article/rs-5...

1 year ago 5 3 0 0
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I have received my copy πŸ˜πŸ“–
#GNN #deeplearning #genomics #bioinformatics

1 year ago 4 0 0 0
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Home A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler

New year, new assemblies!
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)

1 year ago 156 97 2 3
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Ten months ago I posted this comic on LinkedIn. It has received over 300 likes in different forms. With humor, but as a critique of those who don't value our work. Let's keep making our demands in 2025! #Bioinformatics

1 year ago 13 4 1 0
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Re-reading these wonderful pieces preparing for what comes in 2025 πŸ˜‰
#GNNs #deeplearning #genomics #bioinformatics

1 year ago 2 0 0 0
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Very much enjoying the pre-print. I hope Santa brings me the actual book πŸ“–. πŸŽ„ @cambridgeup.bsky.social

1 year ago 1 0 0 0
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Unicore enables scalable and accurate phylogenetic reconstruction with structural core genes www.biorxiv.org/content/10.1101/2024.12.... 🧬πŸ–₯️πŸ§ͺ https://github.com/steineggerlab/unicore

1 year ago 39 20 2 0

Come join the group in Utrecht!Β  I have a post-doc position to fill to work on using microbial genomics and metagenomics to build machine learning models to better understand the spread of pathogens and dissemination of resistance www.uu.nl/en/organisat...

2 years ago 7 7 0 0