ft. Castaño, Bettini, Kumar, Siv, De Luna, Chiu, Hang Li, Ibrahim, Muramatsu, Mdluli @sunnyshinlab.bsky.social @scottehensley.bsky.social Pardi @michelalocci.bsky.social (@pennmicro.bsky.social) Lederer, Maillard & Miner (@i3h-upenn.bsky.social) linkinghub.elsevier.com/retrieve/pii/S0092867425013583

Flyer for CSHA Conference on Bacterial Infection & Host Defense

Deadline extended to March 27th for the CSHA conference on Bacterial Infection & Host Defense May 11-15, 2026! We have a fantastic list of speakers and opportunities for abstract talks. For full details, please visit the conference webpage: www.csh-asia.org?content/2975. Hope to see you in Suzhou!

Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates In severe cases of COVID-19, glucocorticoid treatment improves clinical outcomes. However, in non-hospitalized patients, glucocorticoids have limited benefit and may impair viral clearance. Here, we u...

In this new paper by @nelson-lab.bsky.social, we found that pre-exposure of NHP to glucocorticoids impairs control of SARS-CoV-2 and is associated with reduced pDC, eosinophil and γδT cell responses.

journals.plos.org/plosone/arti...

Ubercool.
Toxin-antitoxin systems were discovered 40 years ago in E. coli, and later on in many genomes including in euks.
Now the 1st TA system is reported in the mouse genome!
It affects embryo killing. Amazing distribution of a simple yet efficient genetic system
www.biorxiv.org/content/10.6...

Check out this collaboration between Kellie Jurado’s lab and mine. We find that paternal immune activation reprograms the epididymis and, subsequently, small RNAs in sperm, which modulate post-fertilization embryonic gene expression and immunity in offspring in a sex-specific manner.

Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

Phosphoinositide and cholesterol are endogenous ligands of STING in innate immune signaling @nature.com @upittpress.bsky.social @utswim.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Fuel the fight! — STAND UP FOR SCIENCE

Ok people!!!

I believe we may be taking March 7th NATIONAL!

This will require financial support. Last year, nationwide, the protests cost $75,000. We need all the help we can get!

Help us fuel the fight here: www.standupforscience.net/donate

@standupforscience.bsky.social
#standupforscience

Mikel Haggadone is holding the AAI Ray Owen Poster Award certificate from the Midwinter Conference of Immunologists

Congratulations to my postdoc @mikelhaggadone.bsky.social for receiving the @aai.org Ray Owen Poster Award at the Midwinter Conference of Immunologists @midwinter-immun.bsky.social for his work with Brian Goldspiel & @metabailism.bsky.social, which is now on bioRxiv! www.biorxiv.org/content/10.6...

I had a wonderful time at Midwinter Immunology & was honored to receive the Ray Owen Poster Award after an awesome presentation by @sunnyshinlab.bsky.social!

2026 was my first time attending — definitely won’t be my last! Thank you to @brodskyigorlab.bsky.social & co. for an amazing meeting! 🙏

Suhas Bobba holding the ASM Infection and Immunity Poster Award certificate at the Midwinter Conference of Immunologists

Congratulations to my
& @brodskyigorlab.bsky.social’s joint postdoc Suhas Bobba on receiving the @asm.org Infection & Immunity Poster Award for his work on innate immune control of intestinal Yersinia infection at the Midwinter Conference of Immunologists @midwinter-immun.bsky.social!

Mikel Haggadone is holding the AAI Ray Owen Poster Award certificate from the Midwinter Conference of Immunologists

Congratulations to my postdoc @mikelhaggadone.bsky.social for receiving the @aai.org Ray Owen Poster Award at the Midwinter Conference of Immunologists @midwinter-immun.bsky.social for his work with Brian Goldspiel & @metabailism.bsky.social, which is now on bioRxiv! www.biorxiv.org/content/10.6...

Excited to announce the upcoming 2026 Microbial Toxins and Pathogenicity GRC and GRS meeting taking place July 12 - 17, 2026 at Waterville Valley in New Hampshire. This meeting will be chaired by yours truly and co-chaired by
@sunnyshinlab.bsky.social www.grc.org/microbial-to...

Thrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...

Excited to share our new pre-print on the control of NLRP3 inflammasome assembly and ASC translation dynamics by environmental amino acids. A true team science effort: our phenomenal partners @mikelhaggadone.bsky.social & @sunnyshinlab.bsky.social working with Brian Goldspiel 🙏

@biorxivpreprint.bsky.social Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly @briangoldspiel.bsky.social @mikelhaggadone.bsky.social
@sunnyshinlab.bsky.social @pennmicro.bsky.social @metabailism.bsky.social
www.biorxiv.org/content/10.6...

Thank you very much Igor for your invaluable feedback and support throughout this project! 🙏

Congrats @sunnyshinlab.bsky.social and colleagues on this super cool and intriguing story on the role of dietary amino acids in regulating NLRP3 inflammasome activation by controlling translation of the ASC adapter! 🤯🙌🏼

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

Thrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...

Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...

Friday we lost a brilliant mind, colleague, and friend to her battle with pancreatic cancer. Those who knew her will remember Helene Andrews-Polymenis for her warmth, generosity and leadership. She will be missed by many. RIP

While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!

So sorry to hear this. Helene was a truly wonderful and inspiring scientist and person. We will miss her dearly.

Congratulations Mia and co-authors on this exciting study!

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions.

A bit of a video explainer here: 1/ 🧪

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested!

arizona.csod.com/ux/ats/caree...