I’ve used AnyDesk for windows machines and been pretty satisfied: anydesk.com/en

there goes the central dogma, i guess. is nothing sacred anymore?

Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was.

This is how it all started...

/1

Ah, Peptides. Where to Begin? Ah, Peptides. Where to Begin?

Buckle up
'So let’s finally talk about peptides. And I don’t mean peptides as chemists and biologists understand them (short chains of amino acids) I mean “Peptides!”, the hot new wonder drugs that you can order by mail. Oh man.'
www.science.org/content/blog...

Reporting for duty 🫡

If you use GitHub (especially if you pay for it!!) consider doing this *immediately*

Settings -> Privacy -> Disallow GitHub to train their models on your code.

GitHub opted *everyone* into training. No matter if you pay for the service (like I do). WTH

github.com/settings/cop...

I’ve been resistant to calling Americans/developed world more broadly politicans/voters “decadent”, but like if you keep knocking loadbearing pillars out of your economy for aesthetic reasons because you don’t care about the consequences - then there really isn’t any other word to use for it

I just had surgery to remove an orange-sized cyst from inside my chest, and the thoracic surgeon and absolutely every RN & NAC has been an immigrant or child/grandchild of immigrants. The U.S. would have no healthcare system without immigration. We’re so fortunate these people made America home.

How do immune disease-relevant variants rewire gene regulation in CD4+ T cells?
In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.

How to Design Antibodies A step-by-step guide to making de novo binders.

I wrote a primer on AI antibody design, published on Asimov press.

www.asimov.press/p/antibody-d...

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

When someone says „Scientists do not want you to know“ you can dismiss everything from there on. Scientists want you to know. They are desperate that you know. They can’t shut up about what they found out and want you to know.

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...

🔗 doi.org/10.64898/202...

congress sounds cool i wish it was real

Funny how “doing things” never seems to include “writing documentation.”

Engineers will say “you can just do things” and then hand-roll the most cursed workflow language you’ve ever seen.

Universität Basel: Bioinformatician (100%) The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health...

We have a 3-years position open in our facility. Come join us to do great science in a nice team!
jobs.unibas.ch/offene-stell...

📢 Hiring! Our group @ncmbm.bsky.social seeks a Research Scientist contributing to:
• Reproducible pipelines for large-scale genomics
• cisreg signature analysis in breast cancer
• Continued development of JASPAR
• Cross-disciplinary collaboration

Apply now 👉
www.jobbnorge.no/en/available...

nf-core Details of past and future hackathons around nf-core.

🎉 Registration for the nf-core hackathon is now open! Join us online or in-person on March 11-13 for collaborative coding, pipeline development, and community building 💻

Bring your own project or choose from our community issues.🔧 Every project has a lead to guide you! nf-co.re/events/hacka...

First, @tattabio.bsky.social is now on Bluesky!💙 and second, we launched mult-sequence CoSearch on SeqHub!

This guy was kidnapped down the street from me. The ICE surge in Minnesota is not over, nor limited to the twin cities. Be safe and please do not be silent or pretend that ICE is de-escalating.

Synovial sarcoma is driven almost exclusively by a single oncofusion – SS18-SSX

For years, the assumptions on disease mechanisms were simple:

➡️ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity

Our new study shows that assumption was wrong 🧵👇

www.biorxiv.org/content/10.6...

An Introduction to Sequence Alignments How bioinformatics learners can use data from the 1,000 Genomes Project to practice basic alignment skills.

Access to high-quality human genomics data can be a major barrier for bioinformatics learners, so I wanted to write a quick post plugging the 1000 genomes project as a source of practice data!

ICE agents to begin checking documents at MSP airport, patrol jet bridges - Minneapolis / St. Paul Business Journal U.S. Immigration and Customs Enforcement agents will begin checking documents of travelers and workers at MSP airport, with patrols inside jet bridges.

It’s been reported locally, but I’m not sure how much national notice this has gotten. As part of this invasion by shithead goons, they are putting ICE agents in jetbridges and other parts of the airport at Minneapolis-Saint Paul. If you are flying Delta via MSP, you are putting yourself at risk.

It seems a lot of people think they know Minneapolis now.
Our flaws. Our faults.

I hope my neighbors join me in reclaiming the narrative.

Minneapolis, through the eyes of someone who actually lives here:

It’s easy to think that schools in Minneapolis are closed because the Feds murdered someone in the street but no, the actual reason is that while that was happening, the Feds were busy doing other heinous shit across the city like tear-gassing a school

Teaching Transcriptomics in a Master’s in Informatics! 🧬 I’m curious about your take on the best format for students: 1️⃣ Practical/Code-heavy + autonomous theory? 2️⃣ A traditional hybrid approach? What works best for informatics profiles? Let’s discuss below! 👇 #Bioinformatics #Transcriptomics

We love to fetishize "top" researchers and give them special big pots of money. But we get far more science by spreading money among all researchers (closer to the NSERC DG model). This old post is magically relevant again... scientistseessquirrel.wordpress.com/2015/05/12/w...

The Ensembl website is so cool, there should be a version of it that works.