Upshot:
🟢 JB says scientist training is his #1 priority.
🔴 Yet, this fiscal year so far, training-related grants are down over 80% from expected levels.
Guys, you can’t do science without scientists. JB gets an F (but not an F grant... ba-dum-tss)
More funding curves at Grant Witness:
A diagram showing that 24 annually funded grants becomes only 15 funded grants if 50% of the funds for competitive grants are used for multi-year funding.
I was preparing for a talk I gave last evening to a lay audience and came up with this graphic to explain multi-year funding and why it leads to fewer competitive awards and funding investigators and projects.
6/8
Believe them when they tell you what they believe in.
This confirms my observations!! Single cell technology really helps! #orangecat #genius
How to disincentivize the already tired/frustrated reviewer pool further…
Will do nothing but reduce quality and continuity of study sections.
Had a great Northern NYC Heme club intro @newyorkbloodcenter.bsky.social ! Great talks across the spectrum of Heme cancer biology, Clonal hematopoiesis, blood cell development from new colleagues across NY :) @sinaiimmuno.bsky.social @cdi-einstein.bsky.social @einsteincellbio.bsky.social
ALRIGHT TEAM! It’s time to spread this far and wide.
This is for parents with young kids, disabled folks, people who have to work, those in the hospital, seniors in nursing homes, our friends in rural places!
We believe in science, health, and democracy for EVERYONE!
This plot from @drugmonkey.bsky.social shows how the number of *new* NIH fellowships to Black investigators plummeted last year. And it's only half the story.
The other half is that *existing* fellowship grants to POC investigators were also *terminated* at disproportionate rates.
This Russell Vought, trying to usurp the power of the purse.
Congress and the people have made it abundantly clear that they want to fund science.
But Vought keeps trying to steal those funds.
www.science.org/content/arti...
we are losing so much talent, progress, and hope for no good reason www.vox.com/future-perfe...
it feels like decades since the first Stand auto for Science protests
ahead of this year’s protests tomorrow, I caught up with @cdelawalla.bsky.social to talk about what @standupforscience.bsky.social sees as its strategy as a fully formed organization
www.statnews.com/2026/03/06/s...
In just 3 days, the Take Back our Science Rally hits the streets in Washington DC and all across the country!
Join at local rally, or if nothing's nearby, start your own pop-up rally. Details at zurl.co/BlOzn
#science
#standupforscience
#rally
#March7
#FunScienceFact
(1/2)
New Yorkers, let your state senator + legislator know you want to support science research at NYS-level to protect other New Yorkers, grow our economy, and create jobs. *Every call/email matters!* Follow @fundnyscience.bsky.social @nycures.bsky.social for how-to 🔬🥼💲
Notable talk from PDs across disciplines at MSSM, such as @alozano22.bsky.social who’s work in diet & liver cancer immunology heavily impacted by public-funding cuts, and how industry-driven funding has different priorities. Many of us feel it similarly @nychealthy.bsky.social @spocuaw.bsky.social
Powerful speech from @brownlab1.bsky.social on need for state-level funding of early research to keep smart folks in NYS and boost retention of startups/industry offshoots! Long term ($$$) stems from smart investment ($) @sinaiimmuno.bsky.social @drshrutinaik.bsky.social @miriammerad.bsky.social
Panel of scientists, state legislators, and UAW region 9A representatives in front of projector at Sinai Goldwurm auditorium.
Heartened to see complementary action @nycures.bsky.social @uawregion9a.bsky.social @spocuaw.bsky.social @rocsuaw.bsky.social driving “bolstering biotech initiative” in NYS for FY26. We need to fight together for rational sustainable research funding given threats/cuts. #science #BBI #NYS
The impact is already hitting science agencies hard. The NIH—the world's largest public biomedical research funder—has had to rely on leftover stopgap funds.
New grant awards have slowed to a trickle — exacerbating the effects of a record-long shutdown in October.
(h/t @jeremymberg.bsky.social)
Similarly, excited to see beautiful direct in vivo reprogramming updates from @cellreprolab.bsky.social Asgard Tx, esp their observation that DC-like reprogrammed tumorcells enhance functional TLS and license abscopal effect. Aligns well with our story coming out soon @miriammerad.bsky.social
Wrapping up #KSMyeloid26, enjoyed @tfabre.bsky.social
rigorous + rational approach to classifying and targeting myeloid cells in fibrotic diseases. Look forward eagerly to testing their M.A.C.S approach built on scLAVI @mmschaefer.bsky.social
FUEL THE FIGHT FOR SCIENCE FIGHT BACK! standupforscience.net/donate
The fight for American science is real and it requires resources. If you can, please help fuel the fight with a donation at standupforscience.net/donate
Thank you!
#standupforscience
#science
#donate
#savescience
#March7
Enjoyed talk from @gaoteng.bsky.social @bloodgenes.bsky.social on mitoDrift, revised approach based on population genetics modeling to account for heteroplasmy drift. Strong vignettes showing their tracing aligns with LARRY groundtruth barcoding, validate reduced My/Ery clonality w/ age. AP-1 again!
Very cool work from AJ Daniels @signerlab.bsky.social who have developed a mouse model for enhanced translational fidelity (Rps23-K60R) that rejuvenates hematopoietic age. Protein synthesis stress decoupled from translational fidelity, such a crucial concept for HSC biology and fitness.
Notable talk from Arushana Maknojia @thekinglab.bsky.social who describes long-range comm between gut microbial metabolites and BM HSCs which activates endog-retroelements (ERE) to support hematopoeitic expansion. Matches what we are seeing in ageing. #sensing #immunology
Excellent short talks now #KSHemato26. First, Sara Tomei @shalinhnaik.bsky.social describing how HaemaTONIC-enabled marker discovery reveals CD200 as a distinguisher for erythroid-biased vs multipotent hu HSCs! V useful as folks design selection strategies clinically. @keystonesymposia.bsky.social
Now at #KSHemato26; Britta Will @einsteinmededu.bsky.social shows super-cool work highlighting the role of chaperone-mediated autophagy (CMA) in HSC function and leukemia resistance. Big role for proteostasis upon cysteine stress, which aligns so well with what I see in pathogenic myelopoiesis !
Final day of #KSMyeloid26 ! Really enjoyed @bainlab.bsky.social talk on RTM repopulation dynamics post-infection. Notable, their work underscores that monocyte replenishment of AM niche (clodr) is sufficient (not Ag from prior infection) for protection. "Monocyte legacy, not training !"
(JUMPING CONF #KSHemato26) Amazing talk from @juliabelk.bsky.social who is doing cutting-edge work to trace replacement of microglia in humans, using passenger mutation-assisted clonal tracing (PACT). More microglia are monocyte-derived than expected, our brains are not as protected after all !
Always a mind-blowing talk from @sancholab.bsky.social
who showed, alongside cool data on macs, that cIII inhibition in cDC1 has functional consequence on anti-tumor immunity > mitochondrial ETC disruption impact on histone demethylase and alter PU.1 pioneer activity. Everything linked !
Next, Isabelle Arnold (ETHZ) with a very intriguing talk on neonatal eosinophil biology, showing elegantly how important this population is to microbial homeostasis and immunity later in life. Alongside @arielmunitz.bsky.social , nice representation for these PHILs. #KSMyeloid26
Afternoon session full of great talk at #KSMyeloid26. First, Zimmerman lab (Oklahoma) walks us through the complex and surprisingly non-canonical behavior of renal macs, specifically how Trem2hi macs dictate PKD phenotypes. @keystonesymposia.bsky.social