αCD40 immunotherapy induces conversion of tumor Treg cells into FoxP3−Tbet+IFN-γ+ “ExTreg” cells that exhibit increased antigen reactivity & spatially associate with Cxcl9+ DC @cp-immunity.bsky.social www.cell.com/immunity/ful... @ohsuknight.bsky.social

Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection

karger.com/jin/article/...

Genetic Insights into Circulating Complement Proteins in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Potential Inflammatory Subgroup #MECFS #LongCovid

www.researchgate.net/publication/...

www.mdpi.com/1422-0067/27...

Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance Slc31a1-mediated copper uptake maintains regulatory T cell function and peripheral immune tolerance.

Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance

www.science.org/doi/10.1126/...

Cancer I’ve taken agency in the treatment of my bone cancer (osteosarcoma in the T5 vertebrae of the upper spine). After I’ve ran out of standard of care treatment options and there were no trials available…

Sid Sijbrandij Cancer Journey

sytse.com/cancer/

x.com/sytses/statu...

Blood coagulability changes in females exposed to dry immersion: examining a mechanism for the development of venous thromboembolism in microgravity The recent report of a blood clot in the internal jugular vein (IJV) of an astronaut aboard the International Space Station (ISS) has prompted the nee…

Blood coagulability changes in females exposed to dry immersion: examining a mechanism for the development of venous thromboembolism in microgravity

www.sciencedirect.com/science/arti...

SFU study sheds light on clotting risks for female astronauts

www.sfu.ca/sfunews/medi...

Microvascular Dysfunction Clinical Workflow Pack

(for discussion purposes only with your licensed clinician)

renesugar.github.io/medicine/art...

How I Diagnose and Treat Microvascular Dysfunction in SSRI Withdrawal and Post-Viral Illness

A Mechanism-Based Approach to Endothelial Instability, Platelet Dysregulation, and Fibrinolytic Failure

(for discussion purposes only with your licensed clinician)

renesugar.github.io/medicine/art...

Nicotine Inhibits FcεRI-induced Cysteinyl Leukotrienes and Cytokine Production without Affecting Mast Cell Degranulation Through Alpha7/Alpha9/Alpha10-nicotinic Receptors Smokers are less likely to develop some inflammatory and allergic diseases. In Brown-Norway rats, nicotine inhibits several parameters of allergic asthma including the production of Th2 cytokines and the cysteinyl leukotriene LTC4. Cysteinyl ...

Nicotine Inhibits FcεRI-induced Cysteinyl Leukotrienes and Cytokine Production without Affecting Mast Cell Degranulation Through Alpha7/Alpha9/Alpha10-nicotinic Receptors #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

ACX-02 (dexmedetomidine and midodrine)

appliedcognition.com/pipeline

Pharmacological enhancement of glymphatic function in humans increases the clearance of Alzheimer’s disease-related proteins Alzheimer’s disease (AD) is characterized by the mis-aggregation of amyloid β (Aβ) and tau, which is proposed to be driven by impaired Aβ and tau clearance. While sleep-active glymphatic transport con...

Pharmacological enhancement of glymphatic function in humans increases the clearance of Alzheimer’s disease-related proteins

www.medrxiv.org/content/10.6...

The brain's cleaning system can be boosted to rid Alzheimer's proteins A duo of drugs that boosts our glymphatic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease

www.newscientist.com/article/2520...

"a fixed-dose combination therapy of intravenous dexmedetomidine (0.7 μg/kg/h) and 10 mg oral midodrine (ACX-02)"

The brain's cleaning system can be boosted to rid Alzheimer's proteins A duo of drugs that boosts our glymphatic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease

The brain's cleaning system can be boosted to rid Alzheimer's proteins

A duo of drugs that boosts our glymphatic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease

www.newscientist.com/article/2520...

Scientists “Bottle the Sun” With Revolutionary Liquid Battery A newly engineered molecule acts like a “rechargeable” solar heat battery, storing sunlight and releasing it on demand.

Scientists “Bottle the Sun” With Revolutionary Liquid Battery #Science #TechnologyandEngineering #LiquidBattery #RenewableEnergy #SustainableTechnology

scitechdaily.com/scientists-bottle-the-su...

Microclot / Endothelial Dysfunction (Post-Viral and SSRI Withdrawal)

Labcorp Requisition: Microclot / Endothelial Dysfunction Panel

Creatine and post-viral fatigue syndrome: an update Post-viral fatigue syndrome, classified as a neurological condition by the WHO (ICD-11 code: 8E49), manifests as persistent fatigue, cognitive difficulties, and post-exertional malaise following vi...

Creatine and post-viral fatigue syndrome: an update

www.tandfonline.com/doi/full/10....

Post-Exertional Recovery Test Panel (PEM / mTORC1–DEAF1 Axis)

Minimal version (if testing access is limited)

Post-Exertional Recovery Test Panel (PEM / mTORC1–DEAF1 Axis)

🧠 Key insight (this is the important part) What your gene set suggests is not a primary RBC disorder, but rather a “triple-hit model” affecting oxygen delivery: 1. Microvascular flow problem SERPINC1 PTGIS → capillary obstruction / dysregulation 2. Oxidative stiffening of RBCs PRDX6 → reduced deformability 3. Systemic metabolic stress DARS2, FBXL4 → worsens RBC energy + redox environment 🔬 Why this matters for ME/CFS specifically This combination maps almost perfectly onto: Reduced capillary perfusion Impaired oxygen extraction “Pseudo-hypoxia” despite normal oxygen saturation 👉 Which is exactly what many ME/CFS physiological studies show.

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS #LongCovid

www.research.ed.ac.uk/en/publicati...

www.pure.ed.ac.uk/ws/portalfil...

Eight-Week Creatine-Glucose Supplementation Alleviates Clinical Features of Long COVID Preliminary studies demonstrated beneficial effects of dietary creatine across different post-viral fatigue syndromes. Creatine is often co-administer …

Eight-Week Creatine-Glucose Supplementation Alleviates Clinical Features of Long COVID

www.jstage.jst.go.jp/article/jnsv...

Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla

www.mdpi.com/2072-6643/16...

Effects of six‐month creatine supplementation on patient‐ and clinician‐reported outcomes, and tissue creatine levels in patients with post‐COVID‐19 fatigue syndrome Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome, possibly due to its energy-replenishing and neuroprotective act...

Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome

onlinelibrary.wiley.com/doi/10.1002/...

Carbohydrate ingestion augments creatine retention during creatine feeding in humans - PubMed Blood and urine samples were obtained from four groups of healthy male subjects (A-D, total n = 22) before, during and after ingesting the following: group A, 5 g of creatine in solution; groups B and C, 5 g of creatine and 93 g of simple carbohydrate in solution: group D, a creatine- and carbohydra …

Carbohydrate ingestion augments creatine retention during creatine feeding in humans

pubmed.ncbi.nlm.nih.gov/8899067/

Eight-Week Creatine-Glucose Supplementation Alleviates Clinical Features of Long COVID Preliminary studies demonstrated beneficial effects of dietary creatine across different post-viral fatigue syndromes. Creatine is often co-administer …

Eight-Week Creatine-Glucose Supplementation Alleviates Clinical Features of Long COVID

www.jstage.jst.go.jp/article/jnsv...

A Case of CMV Disease of the Jejunum in a Patient with Non-Hodgkin’s Lymphoma CMV infection may occur anywhere in the gastrointestinal tract. Among the small intestine, ileum is the most common site of CMV disease and infection of jejunum is a rare one in patients with CMV gastroenteritis. Although rare, the reason why the ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"a case of CMV disease of jejunum in patient with non-Hodgkin’s lymphoma who showed severe ulceration in jejunum and massive intestinal hemorrhage, and he survived after successful treatment with segmental resection of jejunum and intravenous ganciclovir."

A Case of CMV Disease of the Jejunum in a Patient with Non-Hodgkin’s Lymphoma CMV infection may occur anywhere in the gastrointestinal tract. Among the small intestine, ileum is the most common site of CMV disease and infection of jejunum is a rare one in patients with CMV gastroenteritis. Although rare, the reason why the ...

A Case of CMV Disease of the Jejunum in a Patient with Non-Hodgkin’s Lymphoma

pmc.ncbi.nlm.nih.gov/articles/PMC...

Absolutely INSANE twilight aurora just now from my driveway in North Pole, Alaska. Incredible motion and color, one of the best of the season. Watch until the end, wow!

Hypophosphatemia and Hypoxia

www.grepmed.com/images/12039...