PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
🚨NEW paper alert🚨 co-led by Fan Fan, Jane (Qian) Liu (from the zeelab.org), and an interdisciplinary, multi-institutional team using computational image analysis and machine learning methods to identify novel tubular features associated with clinical outcomes above and beyond known risk factors👇
See our paper on the unfortunately popular "time-averaged" method in nephrology literature: doi.org/10.2215/CJN....
"Kidney survival times were calculated from baseline...Change in proteinuria was calculated from baseline value to either lowest proteinuria value or time-averaged proteinuria in the 6–12 and 6–24 months periods after baseline." Ie uses future to predict future which can greatly exaggerate effects 😩
Why not?🤔 Seems like an efficient use of resources to answer multiple questions. I don't see a problem
Flyer from the University of Pennsylvania Perelman School of Medicine Graduate Group in Epidemiology and Biostatistics advertising a Virtual Open House on Graduate Programs in Biostatistics. Date: September 12, 2025, Time: 11am-3pm ET. Learn about MD and PhD Biostatistics programs, hear research talks by faculty and students, chat with current students, ask questions, and win prizes! Find more information at https://www.med.upenn.edu/ggeb/biostatisticsopenhouse2025.html and register for free.
Want to become a pro in statistical analysis? Know someone who might be interested in Biostatistics graduate programs? 📈🧮🖥️🎓 Share and come to the @upenn.edu @dbei-upenn.bsky.social Open House on 9/12/25. Registration is *free* and you could even win some swag! www.med.upenn.edu/ggeb/biostat...
❤️
Morning or mid to late afternoon timing rather than mid-day (lunch time/nap time) 😅
Great you feel supported and kids enjoy participating! And perhaps encouraging for some parents on the fence. For others who don't feel that same support in their cities, with kids afraid of crowds or loud noises, or those just too exhausted, there has to be space for *guilt-free* virtual activism
Hi! 👋 I'm Jarcy Zee, only a pretend adult and pediatric nephrologist, but actually a biostatistician doing lots of GN and other kidney research. Hoping I'm still allowed to hang 😅. First time on #NephJC!
“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.”
www.science.org/content/arti...
#StandUpForScience
#BethesdaDeclaration
"Robustness of results to assumptions" 😅
(but also the standard error matters too!!)
A 10 mg/kg/day increase in cr generation could lead to a 36 ml/min/1.73m2 decrease in eGFR in a 35yo male or 18 ml/min/1.73m2 decrease in a 8yo female with NO actual change in kidney function! 😳
"Besides age, sex, and weight, important factors that can impact creatinine generation include urine protein in children and kidney function, disease diagnosis, steroid use, and nonsteroid immunosuppressant use in adults."
🚨New paper alert🚨 from the zeelab.org. @dbei-upenn.bsky.social PhD biostats candidate Shalini Ramachandra found high variability in creatinine generation among GN pts over time, yet we usually assume it's stable to calculate sCr-based eGFR 😩. Check it out 👇 www.sciencedirect.com/science/arti...
Yes exactly, the latter was my concern. Didn't see the part about autism but would agree 🙄
Can you clarify? When I first saw the CNN article and started looking into Healthy Babies, Bright Futures, I was skeptical (eg, the report is not written how one would expect scientific research to be written), but could not find much info about them
A call to action for researchers to advocate not only for funding but to put pressure on universities, professional societies, and government representatives to protect academic freedom, international scholars, and science as a whole: rdcu.be/elOdv
@super-jrub.bsky.social
Came across this list of free datasets: hbiostat.org/data/#vanderbilt-biostatustics-datasets -- great resource for teaching (and maybe research too)!
Some movement toward NIH support at the congressional hearing on biomedical research today: www.politico.com/live-updates...
This order states Schedule Policy/Career employees: "are required to faithfully implement administration policies to the best of their ability, consistent with their constitutional oath and the vesting of executive authority solely in the President. Failure to do so is grounds for dismissal." It also states that: "the President will make the final decision about which positions go into Schedule Policy/Career." And "guidance about positions agencies should consider in their Schedule Policy/Career positions" includes those with: "Substantive participation and discretionary authority in agency grantmaking, such as the substantive exercise of discretion in the drafting of funding opportunity announcements, evaluation of grant applications, or recommending or selecting grant recipients. Grantmaking is an important form of policymaking, so employees with a substantive discretionary role in how federal funding gets allocated may occupy policymaking positions." This indicates that all involved in all grantmaking are considered policymaking positions and that the President can dictate whether those individuals' actions are aligned with their policies -- no matter who the President is or their party affiliation. Those involved in grantmaking should be nonpartisan career civil servants with appropriate expertise and experience to write funding announcements, evaluate grant applications, and recommend grant funding to achieve the missions of their agencies. They should not have to live in fear that their positions would be at risk if their expert-driven, rigorous decision-making is not consistent with one person's opinions. Adoption of this Proposed Rule will have dire consequences on our country's ability to conduct the best research, educate the best trainees, build the best infrastructure, and provide the best services.
Great idea! Reposting with Alt Text.
Several paragraphs of text quoting from the Office of Personnel Management's Proposed Rule on Improving Performance, Accountability, and Responsiveness in the Civil Service and expressing criticisms specifically about the dangers of considering all involved with grantmaking as policymakers beholden to the President.
Borrowed from @sciencelizard.bsky.social so figured I'd also share for others wanting ideas. Here's mine.
Hey I know these people! Check out this paper👇
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Seems to restrict free speech outside of the conduct of the funded project. They wanted an excuse to cancel any grant...
The damage to the medical school and health sciences will be irreversible. NIH freezes all research grants to Columbia University | Science | AAAS www.science.org/content/arti...
Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it.
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
