🏃♀️ SONA abstract and regular-rate registration closes today at NOON! 🏃♂️
Join us at @mcmasteruniversity.bsky.social on Saturday, May 2, 2026, for a showcase of Southern Ontario’s leading neuroscience research!
Are you heading to #AACR2026 or interested in 3D imaging of human clinical samples for cancer research? Our webinar on “Decoding disease with highly-multiplexed 3D imaging” is in just two weeks: 🗓️ Thurs, 4/30 @ 2PM ET. Register today! bit.ly/4v9aXC1
#FluorescenceFriday #DALISPIM
Samples & data courtesy of: @mblscience.bsky.social, @jtakatoh.bsky.social, @alleninstitute.org
Can we clear it? 🤔 Most likely, yes! This video highlights some of the diverse sample types that have been cleared and imaged with our techniques. What else do you want to see cleared? Leave us a comment! 👇 #tissueclearing #lightsheet #microscopy
The future of human clinical sample research is 3D.
This #FluorescenceFriday data (🔈 sound on!) from Clarence Yapp + Seo Woo Choi shows multiplexed labeling in human tonsil and colon samples imaged on #DALISPIM at 9X.
Register for our 4/30 webinar to learn more: bit.ly/4v9aXC1
We recently hosted a fun lunch & learn with Georgia State's Imaging Core Facility. Chris Tsang introduced our 3D #tissueclearing, labeling, imaging, and analysis pipeline to a roomful of engaged researchers. Thanks to all the attendees for your interest and Core Director Kuangcai Chen for having us!
We also explore representation learning using masked autoencoders (MAE), showing how learned features can help bridge this gap and improve generalization across markers and regions. This suggests that the next step isn’t just better models, but better representation learning at the systems level. 💡
We introduce:
• A whole-🧠, subcellular-res LSFM dataset across 6 markers (NeuN, IBA1, GFAP, TH, cFos, PV)
• Cell centroid annotations (~45K training, ~47K test)
• A benchmark for cross-dataset generalization
• Baseline models showing strong dataset-specific specialization vs. poor generalization
This work addresses a key bottleneck in TB-scale light sheet data analysis: the lack of standardized, high-quality datasets for evaluating cell detection across diverse markers & brain regions. CANVAS democratizes the untapped potential of raw, million-plus cell data for public use & benchmarking.
🎉 Our data science team's paper has been accepted to #CVPR2026! You can read it at arxiv.org/abs/2603.29842 and check out the benchmark page at canvas.lightsheetdata.com. Read on 🧵to learn more about CANVAS, a whole-brain #lightsheet benchmark for cell detection. @cvprconference.bsky.social
Students from the MBL's Embryology course cleared this turtle embryo last year using LifeCanvas Technologies Inc.'s SmartBatch+, labeled with acetylated tubulin to visualize the nervous system, and imaged with the #MegaSPIM light-sheet microscope. #microscopy
Heading to Stockholm this weekend for #FOM2026? You can learn about #DALISPIM and our other 3D microscopy innovations in Dr. Andrew Allan’s talk, “From Tissue to Terabytes: An End-to-End Integrated Solution for Whole-Organ Light-Sheet Imaging”!
🗓️ Tuesday, 3/31 at 16:50 - 17:10
📌 Room M12
💡 @dulaclab.bsky.social at Harvard examines how neuroimmune interactions produce pathogen-specific disease states: www.biorxiv.org/content/10.6...
💡 Mathias Treier’s lab at @mdc-berlin.bsky.social explores the brain regions and neuronal populations involved in coupling circadian rhythm with feeding behaviors: www.biorxiv.org/content/10.6...
💡 @alexkwan.bsky.social's lab at Cornell investigates the effects of psilocybin on neural networks and neural activity: lnkd.in/dVPTUHcKhttp...
We have a special offer for #ABRF2026 attendees supporting neural activity studies! Let us handle clearing, labeling, imaging, & analyzing your samples with our whole-brain c-FOS mapping pipeline. Learn more at bit.ly/4rYBRdf and read on for recent studies using our c-FOS CRO... @abrf.bsky.social
Join us for a webinar on the future of human clinical sample research with @harvardlab.bsky.social! Learn how advances in 3D #microscopy are enabling more accurate cell classification & exploration of novel biology, focusing on samples from melanoma patients. Register: bit.ly/4s4va9G #DALISPIM
To hone in on the specific subpopulations of neurons involved 🔍, they performed chemogenetic silencing of vagal and spinal afferent neurons, and used LifeCanvas whole-body #tissueclearing and #lightsheet imaging to visualize the effects.
In a new Nature paper, @maayanlevy.bsky.social & @christophthaiss.bsky.social's labs demonstrate how age-related changes in the gut #microbiome impair neuronal activation in the hippocampus, leading to memory loss and cognitive decline. Read the study: www.nature.com/articles/s41...
Three scientists in semi-fpormal wear stand in a lab space. One of them cuts a ribbon with big scissors in front of a new microscope that says "DALISPIM" on it. There is a large "GRAND OPENING" banner hanging in the front of the picture, and colorful balloons everywhere.
Four scientists stand in casual wear in a lab space, smiling, around a microscope with "DALISPIM" written on the front. One of them stands behind the microscope comically pointing at it dramatically.
Happy #MicroscopyMonday! Our Head of Innovation Hsuan Lee shared these photos from Peter Sorger's lab (@harvardlab.bsky.social), where we just installed our first #DALISPIM open-top light sheet microscope. Stay tuned for another exciting announcement later this week!
1:28 - @alexkwan.bsky.social’s lab studies how psychedelics impact brain circuitry, uncovering the mechanisms behind their potential therapeutic effects. Learn more in their recent paper: www.cell.com/cell/fulltex...
1:08 - This data from @davidashbrook.bsky.social, Robert W. Williams, and G. Allan Johnson shows Thioflavin S, which is used to stain amyloid plaques in #Alzheimers research, in a whole mouse brain. Check out their latest publication here: www.nature.com/articles/s41...
0:50 - In Yogita Chudasama’s lab at the NIH, Denis Matrov uses the marmoset as a model for studying neural circuitry and behavior. MegaSPIM allows him to image multiple, millimeter-thick sections of marmoset brain tissue at the same time.
0:30 - This video from Joseane Righes Marafiga shows GFP+ cells derived from medial ganglionic eminence (MGE) progenitors 60 days post-transplantation. Check out her recent paper to see how this data helps us understand the neural circuits underlying #epilepsy: www.sciencedirect.com/science/arti...
0:20 - Luis Daniel Estrella uses #MegaSPIM imaging to see vasculature and tau tangles, a sign of Alzheimer’s disease pathology, in millimeter-thick human brain samples. Learn more about the Zwang lab's research in this article: news.harvard.edu/gazette/stor...
0:00 - @jtakatoh.bsky.social cleared and imaged this whole mouse head, skull included, to visualize neural connections between the brain and surrounding structures.
To mark the close of #BrainAwarenessWeek, we have a jam-packed roundup of 3D brain data from our #neuroscience community, spanning research areas from Alzheimer’s to psychedelics. Read on to learn more about the brains in this video! 📖
#FluorescenceFriday
These insights, plus gene expression profiling of activated hypothalamic neurons, shed light on the critical role of hypothalamic glucocorticoid signaling in sex-specific, stress-induced changes in eating behaviors. ➡️ Learn more about the Stern lab: mpfi.org/science/our-... (4/4)
To hone in on the role of the arcuate nucleus, they deleted the glucocorticoid receptor in this specific region... and found that only the male mice 🐭♂️ were affected (increased food intake and body weight). (3/4)
Using LifeCanvas whole-brain mapping of c-Fos and Arc expression, the team noticed:
💡 Significant increases in neural activity in the central amygdala and the arcuate nucleus of the hypothalamus
💡 Reduced overall activity in the hypothalamus
(2/4)
