Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵
www.biorxiv.org/content/10.6...
Happy to share our latest contribution!
How do endosomes get their shape? Well, we show a new role for Arp2/3 in shaping organelles and traffic in fission yeast.
New tricks for an old dog!
Extremely grateful to @hfspo.bsky.social and super excited to set this project in motion together with the incredibly talented @ritamateus.bsky.social and @vmonje.bsky.social Zebrafish hide a secret: lipid membranes shaping the crystals behind their stunning structural colors. How? Stay tuned! #HFSP
Next, work from the Etienne Herzog, @davip-bdx.bsky.social and @fronzeslab.bsky.social using cryo-CLEM and cryo-ET of cortico-striatal dopaminergic synaptosomes to delineate the architecture of non-synaptic modulation: www.biorxiv.org/content/10.1...
This goes beyond my wildest imaginations! Congratulations to @mathilda95.bsky.social @nadlerlab.bsky.social and all the authors! Such a big step forward for membrane biology.
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
Check it out, is finally out!!
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
Any #SpatialTranscriptomics people out there interested in studying #microglial development?
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant
www.hfsp.org/funding/hfsp...
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"
www.pnas.org/doi/10.1073/...
Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪
#neuroskyence
nature.com/articles/s4159…
Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge!
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨
Stunning paper by Anne Simonsen's lab, identifying BEACH domain-containing proteins as membrane coat proteins involved in endosomal sorting: rupress.org/jcb/article-...
Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
Imaging interorganelle contacts at a glance poster Maria Clara Zanellati, Chih-Hsuan Hsu and Sarah Cohen
- Imaging interorganelle contacts at a glance
- Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions
- An Editorial from FocalPlane
journals.biologists.com/jcs/issue/13...
Characterizing heterogeneity in amyloid formation processes pubmed.ncbi.nlm.nih.gov/39566372/
Finally this cool story by @brfalcon.bsky.social is out! 😍😍
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
