Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering T cells are often weakly responsive to tumor self-antigens because of central tolerance, constraining their ability to eliminate tumors. We exploited mechanical force to engineer a weakly reactive T c...

Engineering #TCR #catch #bonds for #tumor #immunity.

@science.org

Chris Garcia @stanforduniversity.bsky.social @hhmi-science.bsky.social

Owen Witte @uclastemcell.bsky.social

Brian Evavold @utah.edu

www.science.org/doi/10.1126/...

Pedro Saavedra of Northeastern (@northeasternu.bsky.social), Kat Barnett of UMich (@umich.edu), Kasia Groburz of Sanford Burnham Prebys (@sbpdiscovery.bsky.social), Cornelius Taabazuing of UPenn (@upenn.edu), Charlie Evavold of Ragon Institute (@ragoninstitute.bsky.social) & Harvard Medical School (@harvardmed.bsky.social), and Jianbin Ruan of UConn (@uconnhealth.bsky.social)

Our Cell Death in Immunity and Inflammation session was phenomenal today at #ASBMB2026.

A pleasure to co-organize this with Cornelius Taabazuing @taabaman.bsky.social.

@ragoninstitute.bsky.social @upenn.edu

Jianbin Ruan, @katbarnett.bsky.social, Kasia Groburz, & @pedrosvdr.bsky.social

#Evavold Lab 2025 Holiday memories.

It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate.

Macrophage Interest Group with Garris lab and Prof. Eric Dang!

@ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social

Scooby Doo and the Cell Death Mystery from #Evavold lab @ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.

Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute Dr. Letai will serve as NCI’s 18th director.

www.nih.gov/news-events/...

Meet Lindsey Adams: a scientist, adventurer, and puzzle enthusiast. As a graduate student working in the Lingwood Lab at the Ragon, Lindsey spends her days studying autoimmune diseases and antibody output, diving into the molecular world of protein interactions.

#WeAreRagon

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Tyler Jacks, Ludwig MIT YouTube video by Ludwig Cancer Research

Ludwig @mit.edu Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y

#CanSky #OncoSky

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Wild.

Cell-intrinsic #proteasome derived #defense peptides.

@nature.com

www.nature.com/articles/s41...

A synthetic chronogenetic gene circuit for programmed circadian drug delivery - Nature Communications Circadian medicine, or chronotherapy, seeks to improve drug efficacy based on individuals’ circadian rhythms. Here, the authors combine principles of tissue engineering and synthetic biology to create...

Wow! #Chronogenetic is here—an innovative system that harnesses circadian gene control to precisely time the release of drugs and compounds in sync with an individual’s natural biological rhythms.

A new era of personalized medicine begins!
🧪

www.nature.com/articles/s41...

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

Great to see paper from Alva Casey out today in Nature Metabolism - from her PhD.
Well done Alva!

doi.org/10.1038/s422...

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

More evidence accumulates that pyroptosis is regulated by ROS after GSDMD cleavage occurs. A beautiful mechanistic study on mitochondrial ROS acting downstream of NLRP3 activation.
Kudos to all authors.
www.nature.com/articles/s42...

Thinking back on all this I better understand the pain I feel to see science under devastating attack here. It’s not just about my livelihood or my university. It’s about my identity. And it’s about a pursuit that I see as standing along with art, literature, and music as among our highest callings.

Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade.

Out now @nature.com from Carlos Donado and Michael Brenner.

@harvard.edu @harvardmed.bsky.social

www.nature.com/articles/s41...

#Evavold lab looking sharp for the #Ragon Institute Winter Party last week.

Institut Pasteur decides to leave X The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

Evavold Lab and Garris Lab 2024 Holiday Dinner!

Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st.

"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology

With lab members Ravi Bharadwaj and Swati Jaiswal, put together this review highlighting the connectivity between transports of cyclic dinucleotides and muropeptide as well as attempted to parse the confusing literature on SLC function in the NOD1/NOD2 pathways: authors.elsevier.com/sd/article/S...