Researchers in #ScienceTranslationalMedicine show that lowering the highly toxic Htt1a transcript with siRNA delays huntingtin (HTT) aggregation and corrects transcriptional dysregulation more effectively than targeting full-length, mutant HTT. https://scim.ag/3NwoFy4
The foothills are still green, but the grasses are yellowing. Shelf Road twists its way towards the East End.
Four runners making their way up a trail, surrounded by chaparral. Nordhoff Ridge in the background.
A view from Nordhoff Ridge Road, where Horn Canton trail drops down. The sign gives distances. On the horizon, Santa Cruz and Anacapa islands poke out of the Santa Barbara channel.
The Topa Topa bluffs pointing the way down to Santa Paula.
A view of the Ojai Valley. A dirt road (Sisar Canyon Rd.) is visible on the far left and far right. Lake Casitas is visible in the upper right third, and the Channel Islands are out on the horizon.
Sisar —> Red Reef —> Nordhoff Ridge —> brief Horn Canyon —> Sisar for some truly spectacular views of the Ojai Valley, Topa Topas, Oxnard Plain, and Channel Islands. Way up with the Sisar Run Club, solo time on the way down.
#trailrun #ojai #sundayrunday
A stream. Mountains behind.
Singletrack heads up through green hills.
Singletrack pointing down through green foothills. Ojai Valley in the background.
Trail on the left, Gridley Canyon on the right, Nordhoff Ridge peaking out in the background.
Oooh, this was a good one. Gridley Trail to the water trough. Not enough time to get to the ridge today.
#trailrun #ojai
That’s a beaut Gerr. Love the moodiness.
Shelf road cuts trough the foothills, blue sky above.
The Ojai Valley looking green. One band of clouds up high, with the sun trying to peak through, and blue skies to the West. Somewhere in the distance near Black Mountain, a helicopter is doin’ something helicoptery.
Shelf Road out-and-back for a nice, round 6.2mi. #trailrun #ojai #usemetric
A dirt road on the left, orchards stretching out to the foothills, which are getting bands of rain.
Moody clouds over the Ojai valley.
Snuck out for a run between bouts of rain. Great clouds today. Stayed mostly dry 🙄. #trailrun #ojai
Looking down the Ojai Valley from the foothills. Orchards to the left, some trails in the foreground.
Luci’s trail, with some cool sandstone rock, leads down to Shelf Road which is visible to the left.
A nice view of Fox Canyon trail from Luci’s, which is across the canyon.
*with the 🤦♂️
Three people sitting on sandstone boulders, looking out into the abyss. One points.
Seven people stand on a rock in front of a pine tree. You can’t tell, but they just climbed 3k ft in 5mi 😅.
Four trail runners headed down a California loamer.
A hot Chorro Grande to Pine Mountain Road with the Sisar Canyon Run Club today. Followed by a super satisfying burrito either the gang. #trailrun #ojai
Moonrise behind an oak tree, a crowd gathered around two musicians who are lit in a warm glow.
Hand-held 10 sec exposure from last night’s Sisar Canyon Run Club’s Tiny Moon Concert / trail run gets the vibe right. #beavermoon #trailrun #ojai
A flat suburban multi-use trail beneath a coast live oak.
Sunset over green hills. A palm tree in relief.
Pink hills over Shelf Road and the green orchards of the East End.
A pink band of light graces the Topa Topas.
One more day off running. Caught a glorious #ojai sunset and #pinkmoment
Lisan al-Ghaib!
The Ventura River Preserve is backlit, with streaks of sunlight cutting through the haze.
Climbing through a shaded Wills Canyon. Will I get jumped by a cougar hiding in the trees?
Sunlight and chaparral. Blue skies above green hills.
A hazy Ojai Valley in the distance, the Alan Jacobs trail in the foreground.
Rolled my ankle yesterday, so giving it the day off of running. Singletrack sampling from the Ojai River Preserve. #ojai
Green hills and Sisar Canyon leading down to Upper Ojai
Looking up at the bluffs of the Topa Topas. Blue skies above.
Fun one with the Sisar Canyon Run Club today. #trailrun #ojai
The Ojai Valley, looking surprisingly green for late October, sits below blue skies and a touch of haze.
On the bike today. Looking good out there, #ojai
A light haze in the air as the sun warms the East end of Ojai.
Made an out-and-back out of the ‘ol trusty Shelf Road loop for a couple of bonus miles today. #ojai #trailrun
Blue skies and clouds over the Topa Topa mountains.
Trail run with a view today.
*Careless Whisper intensifies*
Amazing.
Frankly, I’d like for MBI to let ME know.
Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...
imagine cradling your newborn in your arms, looking into his eyes for the first time, and naming him Jeff
Close To Jeff Sort of a perk, right? Okay, sure, you and Jeff aren’t that close these days, but in theory it might be nice to see him more often. He could, like, come over for beers in the garage sometimes. Reference #34675
NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/davi...
Not the neuroplasticity I was hoping for.
I love this.
A dark-brown mushroom that’s huge is growing out of some ferny woods.
Some stripey mushrooms growing out of a downed tree. Some lush green moss is also visible.
Shot from below of a mushroom growing out of a tree, its gills are visible through the mushroom’s body.
Some more stripey shrooms.
Went for a lovely, dark, wet walk in the woods with my kid today. Found lots of mushrooms, had a great time. Feel free to chime in if you know what they are, because I’m hopeless.
#pnw #mushrooms
