PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis - Nature Metabolism Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...

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🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇
www.nature.com/articles/s42...

Congrats! Great work 🎉

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that:
www.nature.com/articles/s41...

Methods in Enzymology, Vols 726-728: Lipids & Membranes

Vol 726: Detection by Imaging & Lipidomics www.sciencedirect.com/bookseries/m...

Vol 727: Dynamics & Interorganelle Transport www.sciencedirect.com/bookseries/m...

Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

Final week to apply: GSO Leadership Academy 10

The GSO Leadership Academy is an interactive program designed to support researchers who want to develop leadership skills for academia and beyond.

📅 Application deadline: March 1, 2026
🔗 More information: gsonet.org/foerderprogr...

Join us next Tuesday for the next @dgz.bsky.social workshop on #trafficking and EVs! Spread the word please!

Structural basis of caveolin-driven membrane bending www.biorxiv.org/content/10.6...

Lipids challenge ligands to control receptors

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

🔗 buff.ly/G1Zl6cZ

Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -

Triglyceride/Cholesterol Ester Ratio Encodes Lipid Droplet Size and Diversity www.biorxiv.org/content/10.64898/2026.01...

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...

Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳

www.nature.com/articles/s42...

Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

With so many great reviews on LDs already out, do we need another?

Sarah @cohenlaboratory.bsky.social and I were approached by
@natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project!
www.nature.com/articles/s41...

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...

I was part of the GSO Leadership Academy in 2023 and learned a LOT! I can highly recommend to apply. Still using techniques & advices in my everyday young PI life. And the best - it comes with an amazing peer group!

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days.
www.nature.com/articles/s41...

Wow! Great story, I am looking forward to read the paper in depth. Congrats to all authors 🎉

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇

Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!

Great Thread/ summary about interesting lipid related papers of 2025 👇

This is great!! Thank you

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime:

rupress.org/jcb/article/...

Just quit Quitting projects in science is hard, but we should be doing a lot more of it.

Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com/pub/arjunraj...

The protein denitrosylase SCoR2 regulates lipogenesis and fat storage Removal of SNO groups from hepatocyte and adipocyte proteins induces lipid synthesis and weight gain.

Researchers have identified the protein SCoR2 as a potential drug target for obesity and hepatic steatosis in studies of mice, showing that it prevents fat accumulation and weight gain.

Learn more in #ScienceSignaling: https://scim.ag/4p5KxNe

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!

Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC ☀️I can highly recommend 👇

Self-renewal of neuronal mitochondria through asymmetric division Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com