Dose-response curve showing cumulative mortality of Cypridopsis africana after 48 h of exposure to Roundup at 27°C and 31°C. (A) 27°C. (B) 31°C.
Yusuph A. Kafula shows that increasing temperature exacerbates acute toxicity effects of a glyphosate-based herbicide (Roundup) on the ostracod Cypridopsis africana. doi.org/10.1242/bio....
David Díaz-Ortegón and colleagues integratively characterise the #zebrafish TRHergic system, demonstrating early developmental activation, tissue- and sex-specific expression, and a conserved metabolic role in glycemic regulation. doi.org/10.1242/bio....
#TRH
Relationship between exploratory behavior and routine metabolic rate. (A) Relationship between routine metabolic rate and the boldness index. (B) Relationship between routine metabolic rate and individual exploratory behaviors. Correlation type and P-values can be found in Table S1. Female TU, n=30; male TU, n=30; female WIK, n=31; male WIK, n=33. *P<0.05.
Aliyah Goldson and colleagues show that metabolic rate does not predict exploratory behaviour in adult #zebrafish. These data do not support the pace of life syndrome hypothesis.
doi.org/10.1242/bio....
#Boldness #Metabolism #OxygenConsumption
Screenshot of a Biology Open editorial titled “Biology Open 2025 – a year in review,” published 30 March 2026 by Daniel Gorelick. The page shows the article title, author, DOI link, and opening paragraphs discussing transparency, bibliometric reporting, and the introduction of transparent and fast & fair peer review at Biology Open
In this Editorial, our Editor-in-Chief @danielgorelick.bsky.social assesses Biology Open's performance in 2025. doi.org/10.1242/bio....
Iris Sanou
Read our interview with co-first authors Iris Sanou and Mathangi Lakshmipathi to learn more about the research in this article. doi.org/10.1242/bio....
Proliferation of germ cells (OCT3/4 and MAGE-A4) and Sertoli cells (SOX9) in the developing human testis. (A) Representative image showing co-staining of OCT3/4 (red) and Ki67 (yellow) from a PCW 14 foetal testis, with white arrowheads indicating double-positive cells. Scale bar: 50 μm. (B) Representative image showing co-staining of MAGE-A4 (blue) and Ki67 (yellow) from a prepubertal testis aged 8.5 years, with white arrowheads indicating double-positive cells. Scale bar: 50 μm. (C) Representative image showing co-staining of SOX9 (green) and Ki67 (yellow) from a PCW 16 foetal testis, with white arrowheads indicating double-positive cells. Scale bar: 50 μm. (D) Percentage of proliferative Ki67+ cells within the SOX9, OCT3/4 and MAGE-A4 cell populations. Data shown are mean±s.d. (n=3 for PCW 11, 12 and 16-20; n=2 for PCW 7, 9, 10, 13 and 14, 4 years, 6.5 years and 13.5 years; n=1 for PCW 8, 15 and 21, 2 years, 2.5 years, 7 years, 8 years, 8.5 years, 10 years, 10.5 years and 11 years).
Iris Sanou, Mathangi Lakshmipathi & co map how cells in the human testis mature from early foetal life through childhood. doi.org/10.1242/bio....
Deadline to apply is 20 April
Actomyosin contractility and F-actin integrity are necessary for ADIP planar polarization in neuroectoderm. (A) Experimental scheme. Embryos were treated with different drugs to inhibit the RhoA–ROCK–Myosin pathway and were double stained at stage 16 for ADIP and Wtip. (B) Low magnification dorsal view of stage 16 neurulae. Scale bar: 20 μm. Dashed boxes denote the anterior neural ectoderm shown at higher magnification in C-C″,E-E″,G-G″ and I-I″. The anterior-posterior (AP) axis is labeled, and the neural plate is outlined with dashes.
Satheeja Santhi Velayudhan & co demonstrate that endogenous ADIP forms puncta that polarise during wound repair and neural plate folding. They also show that this localisation requires the PCP component Diversin, along with intact microtubules and actomyosin networks. doi.org/10.1242/bio....
Breakdown of costs for BiO in 2025. Manuscript processing and publication costs include services from our typesetting service provider, manuscript submission system and online hosting platform. Travel and expenses are costs incurred in conference attendance by our Managing Editor and any Academic Editor travel on behalf of the journal. Community engagement includes costs of running and staffing our community site, preLights.
Why is publishing so expensive? In this Editorial, we tackle this and other FAQs on publishing finances, providing some context around the revenues and costs at BiO and highlighting the people, workflows and tools that go into publishing a paper with us. doi.org/10.1242/bio....
#AcademicPublishing
Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
This article was handled through our Fast & Fair peer review workflow. This initiative aims to provide authors with a first decision post review within 7 working days. Read more articles handled through our Fast & fair peer review in our collection. bit.ly/4fiAxNE
Visualizing Notch-induced transcriptional response in glp-1 loss-of-function mutants. (A) A schematic of adult C. elegans hermaphrodite with a focus on two U-shaped gonads. The distal tip cell (DTC, germline stem cell niche) is located at each distal end (black crescents). Germline stem cells (GSCs) are indicated in orange. Differentiating cells are in brown, and oocytes are in dark brown.
The Notch signalling pathway is crucial for germline stem cell regulation in C.elegans, but the consequences of GLP-1/Notch mutations remain unclear. Now, Nimmy John & co perform a systematic single-molecule analysis of C. elegans GLP-1/Notch mutations. doi.org/10.1242/bio....
#NotchMutations
Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
This article was handled through our Fast & Fair peer review workflow. This initiative aims to provide authors with a first decision post review within 7 working days. Read more articles handled through our Fast & fair peer review in our collection. bit.ly/4fiAxNE
Elise McKean
Read more about this research in our interview with Elise McKean. Elise is a PhD candidate in Damien O'Halloran's lab at The George Washington University, USA, investigating the molecular mechanisms that impart drug resistance in hookworm.
Cheminformatic and genomic pipeline used to prioritize repurposed anthelmintic candidates. Schematic overview of the computational workflow used to identify candidate anthelmintics from approved drugs in DrugBank.
Developing new medicines takes a long time & costs a great deal of money. To help address this, Elise McKean & co look for new uses for old medicines 💊 that have already been approved. Using computer-based tools, they discover that flutamide can also kill parasitic worms🪱 . doi.org/10.1242/bio....
Advert for BiO Global South travel grants, deadline 19 June 2026, with audience photo and a Biology Open logo
BiO is pleased to launch a new grant: BiO Global South Conference Travel Grants, to help ECRs based in the Global South attend international biological and biomedical science conferences.
Next application deadline: 19 June 2026.
tinyurl.com/22zx7msy
A powerful new toolkit for precise genome engineering in #zebrafish.
This study from the group of Junsu Kang introduces a versatile mini golden system which allows for one-step customization of donor templates + a synthetic exon strategy enabling highly precise genome edits.
doi.org/10.1242/bio....
BiO joins Peer Community In as a PCI-friendly journal. Submit your PCI recommended preprint to BiO for a decision within five days. Find out more: peercommunityin.org/pci-friendly...
How does environment shape C. elegans biology?
Aurélie Guisnet & team @michaelhendricks.bsky.social compared worms raised in 3D scaffolds vs. on 2D agar plates - and find striking differences in (among others) body size, reproduction, stress resistance & exploratory behaviour
doi.org/10.1242/bio....
You can hear from Hehnly Lab PhD Graduate, Favour Ononiwu, in a first person @biologyopen.bsky.social interview about her recent study. Check it out here: journals.biologists.com/bio/article/...
Jessika Wise
Read our interview with Jessika Wise, who was a PhD candidate at the University of Otago Christchurch, New Zealand when she conducted this research interrogating how matrix stiffness affect breast cancer cells.
doi.org/10.1242/bio....
Figure showing breast cancer cell expression of E-cadherin, N-cadherin and Vimentin when cultured in GelMA hydrogels of different stiffness.
Jessika Wise, Khoon Lim, Elisabeth Phillips and colleagues use 3D cell culture in hydrogels to show how matrix stiffness affects breast cancer cells, including changes associated with epithelial-mesenchymal transition.
doi.org/10.1242/bio....
Sriikhar Vedurupaka
Bita Jadali
Read our interview with Sriikhar Vedurupaka @vsriikhar.bsky.social and Bita Jadali @bitajadali.bsky.social, co-first authors working in Alberto Stolfi’s lab at Georgia Institute of Technology, Atlanta, GA, USA.
doi.org/10.1242/bio....
Figure showing that Protocadherin.e (Pcdh.e) is expressed in oral siphon placode (OSP) cells.
Sriikhar Vedurupaka @vsriikhar.bsky.social, Bita Jadali @bitajadali.bsky.social, Alberto Stolfi, Sydney Popsuj @asydnianscience.bsky.social and colleagues discover a role for protocadherin-mediated cell-cell interactions in oral placode morphogenesis in Ciona robusta.
doi.org/10.1242/bio....
Louis Widom
Read our interview with Louis Widom, a PhD candidate in Thomas Gaborski's lab at the Rochester Institute of Technology, USA, investigating the role of pathogenic bacterial extracellular vesicles in sepsis and in disruption of the blood-brain barrier. doi.org/10.1242/bio....
Antibiotic treatment can increase the amount of LPS per BEV. Bar plot of the LPS concentration per individual BEV as measured by a chromogenic endotoxin quantification kit. n=4, except RS218 Control (n=7). Error bars=s.d. Performed two-way ANOVA with Tukey post-hoc test and found a significant effect due to the different E. coli strains: *P<0.05, **P<0.01, ****P<0.0001.
Bacteria produce nanoparticles that cause inflammation. Louis Widom & co demonstrate that treating bacteria with different types of antibiotics leads to changes in the potency of these nanoparticles, which can alter the response of the cells that line blood vessels. doi.org/10.1242/bio....
Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
This article was handled through our Fast & Fair peer review workflow. This initiative aims to provide authors with a first decision post review within 7 working days. Read more articles handled through our Fast & fair peer review in our collection. bit.ly/4fiAxNE
Intercept- and slope-repeatability estimates plotted for activity, aggression and boldness across trial days and testing waters for conditioning regimes. Conditioning regimes are color-coded with each dot in the graph representing posterior mean and the corresponding line bars being the spanning 95% credible intervals. Panels A and D represent intercept- and slope-repeatability estimates for activity; B and E are for aggression and; C and F are for boldness.
Bhavya Pratap Singh and Anuradha Bhat show that environmental unpredictability affects behavioural trait covariation, and within-individual integration, enhancing plasticity and flexibility in #zebrafish coping behaviours. doi.org/10.1242/bio....
Fast & Fair peer review. A new initiative offering high-quality peer review within 7 working days of submission.
This article was handled through our Fast & Fair peer review workflow. This initiative aims to provide authors with a first decision post review within 7 working days. Read more articles handled through our Fast & fair peer review in our collection. bit.ly/4fiAxNE
Gap junctions in accessory cells are required for the instructive signal. (A) A schematic representation of accessory cell development. Photoreceptor cells R7, R8, and R1 (yellow circles) have direct contact with each other at the four-cone cell stage. Anterior–posterior (AP) and dorsal–ventral cone cells are shown in blue and light blue, respectively. Primary pigment cells (PPCs: light brown, 1°) are induced by AP cone cells, and secondary (2°) and tertiary (3°) pigment cells (dark brown) form a lattice of ommatidia. APF, after puparium formation. (B) Two major subtypes of ommatidia. Rectangles and circles represent rhabdomeres and nuclei of photoreceptor cells, respectively. Rhodopsin expression (Rh1, Rh3-Rh6) in rhabdomeres is shown in differently colored rectangles. Photoreceptor cells R1-R8 are shown in white characters. Dve expression in nuclei is shown with magenta circles. The instructive Rh5-inducing signal from R7 to R8 is shown by a curved light blue arrow. Horizontal sections of R7 and R8 layers show the position of rhabdomeres and cell bodies.
Xuanshuo Zhang & co show that functional coupling of two different neurons in #Drosophila photoreceptor cells is established through gap junction-mediated signalling from adjacent accessory cells.
Binyi Yang, Mustafa Khokha & co from @yaleschoolofmed.bsky.social show that CCDC57 is essential for motile cilia structure and left–right axis formation, linking Xenopus developmental defects to human laterality disorders. doi.org/10.1242/bio....
