Dans cette terrible maladie, les motoneurones, cellules à l’origine des mouvements volontaires, se dégradent, entraînant une paralysie progressive.

Ce sont des protéines qui sont en jeu. Et on sait maintenant précisément comment elles sont produites !
👉 https://l.sciencesetavenir.fr/9O7

Kudos to @eriani-martinlab.bsky.social and team for this important discovery !

#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD).

👉 www.cnrs.fr/en/press/discov...

Maladie de Charcot : le mécanisme à l’origine de la forme génétique de la pathologie a été découvert La découverte du mécanisme biologique à l’origine des formes génétiques de maladie de Charcot offre une cible thérapeutique prometteuse.

Maladie de Charcot : le mécanisme à l’origine de la forme génétique de la pathologie a été découvert
theconversation.com/maladie-de-c...

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...

I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...

Congratulations to Yann Tardivat for his PhD defense last Friday October 10th on the translation mechanisms during SARS-CoV-2 infection. A collaborative project with @novalix_pharma ! #sars @ARN67IBMC @unistra

Last Wednesday October 8th, Antoine Perret defended his PhD entitled: Investigation of Tau mRNA translation mechanisms in Alzheimer’s Disease patients. Congratulations for this great achievement. A great collaborative project with @LucBuee and Malika Hamdane from Lille University

#emblprotein #emblprotein #research #translation #molecularbiology #collaboration #als #ftd #c9orf72 #neurodegenerativediseases | Paulo da Costa I had the privilege to give the talk "Targeting dipeptide repeat protein synthesis rescues C9ORF72-linked ALS/FTD phenotypes" at the Protein Synthesis and Translational Control Conference (#EMBLProtei...

www.linkedin.com/posts/activi...

Congratulations to Augustin Burn who tremendously succeeded in the grant competition for a PhD fellowship, welcome to the lab Augustin, we are looking forward to working with you!!!!

I’ve just done my #eXit! the X exodus is massive. Don't lose any of your followers. Thanks to #HelloQuitX I've registered 338 new passengers for a journey to #BlueSky & #Mastodon. Join us on app.helloquitx.com and automatically find your communities on #January20!

La traduction : de l’ARN messager à la protéine La traduction correspond à l'étape de décodage de l'information génétique contenue dans l'ARN messager pour produire une protéine. Cette étape essentielle dans l'expression du génome nécessite l'inter...

planet-vie.ens.fr/thematiques/...

FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr

Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...

Des gens fuient un ascenseur nauséabond marqué du logo de X. Pour se protéger, ils portent des masques en forme de papillon. Dessin : Cartooning For Peace

🔥🔥🔥 Notre app #HelloQuitteX est sortie ! Récupérez vos followers de X en moins de 5 min, il suffit de récupérer votre archive X.
Le #20Janvier, on vous reconnecte avec tous vos abonnés de X !
Yes we can !
Rejoignez ➡️ app.helloquitx.com
Dessin de @cartooningforpeace.bsky.social

FTLD-mapt mutations and short 5′UTR tau mRNAs increase tau translation Abstract. Tau protein plays a central role in Alzheimer's disease (AD) and other Tauopathies. Tau proteins aggregate in degenerating neurons and its expres

Our latest study on Tau translation is online

#MAPT #Tau #Alzheimer

@ErianiLab

@LucBuee

academic.oup.com/narmolmed/ad...