Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus - Nature Communications Kohl et al. combine high-resolution Ribo-seq and cryo electron microscopy to show that the bacterium Staphylococcus aureus uses extended Shine-Dalgarno motifs to initiate translation, which can m...

Very happy to share our latest work on translation initiation and its regulation in S. aureus.
If you are interested in #ribosomes, #bacteria and #translation, this one is for you!
Very grateful to all co-authors, especially @bahcer.bsky.social for an amazing job at Cryo-EM data processing!

Visit from a friend and great colleague from Newcastle University. Sergey Melnikov will after snowy February in Providence talk tomorrow about hibernating ribosomes. Another talk at Brown RNA Center. #ribosomes #RNA

Specialised #ribosomes in plants

Protein Termini 2026 – International Society for Protein Termini (ISPT)

8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/

Ribosome biogenesis and homeostasis: in the front line to cope with cellular stress Cells must continuously adapt to both internal and environmental stresses by finely tuning their molecular and metabolic activities. One of the most r…

Fascinated by how cells adapt to a plethora of stimuli?

​This review describes how cells use and modulate #ribosomes to cope with stresses. We discuss the central role of ribosome-associated processes in #cellplasticity, #signaling, #geneexpression and #diseases 🕹

@cbitoulouse.bsky.social

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...

I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...

#2025Rewind ⏪ Cells must eliminate faulty #ribosomes to stay healthy. A new pathway discovered by Stowers scientists reveals how defective protein-making machines are identified and discarded.

Read more: www.stowers.org/news/finding...

⭐NAR Breakthrough! ⭐

🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...

@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/...

📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...

#Melanoma

Assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumour immunity Original paper: [LINK] Video summary by Eleonora Leucci (KU Leuven) Cinque et al. demonstrate that inhibition of a cancer-specific transcript makes human drug-tolerant persister cells visible to…

The assembly of cancer-specific #ribosomes by the #lncRNA LISRR suppresses #melanoma anti-tumour immunity, say Sonia Cinque, Yvessa Verheyden, Sara Adnane, Eleonora Leucci @leuccilrcb.bsky.social et al. (KU Leuven): rupress.org/jem/article/...

🎥 Video summary by Leucci: youtu.be/AKSuTne83jQ

In @jem.org, Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/...

🎥 See a short video summary: youtu.be/AKSuTne83jQ

#Ribosomes

Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/...

🎥 See a short video summary: youtu.be/AKSuTne83jQ

#Ribosomes

Insights into how –and why– #polyubiquitin chain architecture on collided #ribosomes is maintained:
Toshifumi Inada, Yoshitaka Matsuo et al find that distinct roles of yeast deubiquitinases Ubp2 and Ubp3 are essential for maintaining persistent #RQC activity
www.embopress.org/doi/full/10....

📚 On top of your reading list

🆕Review: Mitochondrial ribosome biogenesis and redox sensing

🔓https://buff.ly/4eG5haI

@brischigliaro.bsky.social

#Mitochondria #RedoxBiology #Ribosomes #Mitoribosome

So what do genes actually do? They code for protein of course! Show the amazing way proteins are made from genes with our Simple Protein Synthesis paper model! Find out more here: origamiorganelles.com/collections/...

#EduSky #iteachbio #proteinsynthesis #mRNA #DNA #ribosomes

Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2
www.embopress.org/doi/full/10....

Protein powerhouses! 💪 Find out which cell component is the MVP of protein assembly. You might be surprised! 🤔 #sciencefacts #cellbiology #proteinsynthesis #ribosomes #sciencetok #biologyclass

Join — The Sinha Lab We welcome curiosity-driven individuals excited to make foundational discoveries aimed at understanding and combating defects in translational control and proteostasis in a dynamic, collaborative, and...

We are hiring at all levels, so please help spread the word! #RNAsky #ribosomes #signaling #translation sinha.biochem.utah.edu/join

🏖️Our August issue's out!
Cover: Flexibility of #autophagy initiation

👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...

Ribosomes On the Road: Neurons Assemble Protein Factories Far from the Nucleus New study shows ribosome biogenesis can occur within neuronal branches, challenging traditional textbook biology.

🚛 Ribosomes on the road! New research from the Schuman Lab @mpibrain.bsky.social shows neurons can locally assemble ribosomes - far from the nucleus and close to synapses. A big shift from textbook biology! 📚🧬🔗 bit.ly/3GUJKPv #Neuroscience #CellBiology #Ribosomes

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

This work is the result of a fantastic collaboration between my lab at the University of Michigan, Mitchell Guttman lab at Caltech, and Marko Jovanovic lab at Columbia University.
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA

How influenza A virus NS1 impedes transcription of the host cell’s messenger RNAs - npj Viruses How influenza virus non-structural protein NS1 inhibits the activity of nuclear speckles, these liquid-liquid phase separation complexes that control the transcription and post-transcriptional…

How #influenza A #virus #NS1 impedes transcription of the host cell’s messenger #RNAs ...

| #InfluenzaA | #mRNA | #proteins | #ribosomes | Via @nature.com

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

👉 buff.ly/YCtPXFk

#Ribosomes #mRNAtranslation

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

In York this Saturday?

Tessa Chan (@ribochique.bsky.social) will be waxing lyrical about #ribosomes - the molecular restaurant in our cells - at #SoapboxScience as part of @yorkfestofideas.bsky.social 👩‍🔬🧑‍🔬🔬🗣️💡

Hear from Tessa & other brilliant female and non-binary scientists 👉 tinyurl.com/rut4mkfh

📣 A new #Breakthrough article published in NAR reveals how ribosomes in eukaryotes maintain high levels of accuracy during translation compared to prokaryotes. 👉 Read the full article here: academic.oup.com/nar/article/... #Ribosomes #RNA #Translation

Ribosome association inhibits stress-induced gene mRNA localization to stress granules A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...

Finding faulty ribosomes: A new collaboration from the
@kkostova.bsky.social Lab uncovers how cells cope with defective #ribosomes published in @cp-molcell.bsky.social. This could shed light on how failure to clear such ribosomes can lead to disease.

Read more: bit.ly/3SlXxQZ

Our research group studies #ribosomes. Our favorite region of interest is the ribosomal tunnel. We realized that it has been missing a Wikipedia page until now, so we decided to create one. Read, edit, enjoy👇

en.wikipedia.org/wiki/Ribosom...