The study, published online in 2025 in Horticulture Research, shows that targeted editing of uORFs in the key diterpene synthase gene SmCPS1 significantly increases tanshinone accumulation in plant roots.
#uORF #Tanshinone
Details: doi.org/10.1093/hr/u...

Targeted BDNF upregulation via upstream open reading frame disruption To understand the relative contributions of 5ʹ UTR elements to translation output, we performed a comprehensive analysis of upstream open reading fram…

Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti...

#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing

Ribosome association inhibits stress-induced gene mRNA localization to stress granules A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...