Identifiquen una diana terapèutica que permetria frenar la propagació dels coronavirus Es tracta d'un enzim que s'activa en les cèl·lules humanes com a resposta a l'estrès degut a la infecció i provoca canvis en la maquinària cel·lular que afavoreixen la producció i la propagació dels c...

1/ 🎯 A therapeutic target that would curb the spread of #coronaviruses has been identified

It is an enzyme that is activated in human cells in response to stress due to infection and causes changes in the cellular machinery that favour the production and spread of coronaviruses
tuit.cat/5y9Rr

Investigadores de la @ptisg.bsky.social pertenecientes al @i2sysbio.es participan en este estudio, en el que identifican que un coronavirus que infecta a los cerdos utiliza DPEP1 para entrar en las células

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬

Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social

www.embopress.org/doi/full/10....

Virus researchers! Please consider participating in this project - it would be a huge help to our lab, and we think it'll lead to some really exciting synthesis. Plus, you'll get an invitation to participate in a workshop later in the project! 🦠😷

The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions The cell that a virus replicates in i.e., the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced. Herpes Simplex virus type 1 (HSV-1) prim...

Some good news to push against the dark. Excited to share our latest pre-print from the lab.
www.biorxiv.org/content/10.1...

What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠

By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️

People do forget how common zoonotic exposure is. In this study 12% of people working in the guano industry in Myanmar were seropositive for sarbecoviruses: pmc.ncbi.nlm.nih.gov/articles/PMC...

🚨Job offer at our research institute I2SysBio 🇪🇸: Contract for International Program Management, specialized in ERC @erc.europa.eu programs 🧪 #science #researchgrants #JOBOFFER #i2sysbio @ucciuv.bsky.social @csic.es @uv.es

i2sysbio.es/position/4/

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity Communications Biology - Identification of safe and effective broad-spectrum antivirals based on modified chitosan sulfate derivatives.

Our recent collaborative work showing the promising broad-spectrum antiviral activity of chitosan sulfate derivatives against SARS-CoV-2, RSV, and Sindbis virus is finally online. Check it out! Detailed mechanisms and in vivo characterization included! rdcu.be/eb9IQ

Dipeptidase 1 is a functional receptor for coronavirus PHEV Coronaviruses of the subgenus Embecovirus include several relevant pathogens such as the human seasonal coronaviruses HKU1 and OC43, bovine coronavirus, and porcine hemagglutinating encephalomyelitis ...

🚨 Preprint alter - bis 🚨

I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠

This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.

A 🧵 below...

www.biorxiv.org/content/10.1...

Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors - Nature Microbiology Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal v...

To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below.
www.nature.com/articles/s41...

Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...

In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization

Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation

www.biorxiv.org/content/10.1...

Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists Origins and spread of the vaccine-derived viruses remain mysterious

Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...

👀👀👀👀👀👀 We should sample more cute animals for weird viruses!!! 🐼🐼

Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾

I think this is a big assumption! More data is needed to confirm the different evolutionary patterns in envelope acquisition

Phylogenetic evidence supporting the nonenveloped nature of hepadnavirus ancestors | PNAS Reverse-transcribing animal DNA viruses include the hepadnaviruses, a well-characterized family of small enveloped viruses that infect vertebrates ...

Excited to share our latest publication on a newly discovered ancestor of Hepadna and Nackednaviruses, found in bat feces in Spain! This discovery provides new insights into the evolution of these virus families and their origins.

Read more in PNAS: www.pnas.org/doi/abs/10.1...