GRAMD1C-mediated cholesterol transport is critical for viral replication. Top: Schematic of cholesterol transport by the GRAMD1C ASTER domain from PM to ER. Bottom: Confocal fluorescence microscopy analysis of the co-localization of TGEV dsRNA (indicated in magenta), ectopic expression of GRAMD1C-HA (indicated in green), and ER-tracker pDsRed2 (indicated in red) in WT cells mock-infected or infected with TGEV (MOI = 0.1), at 12 hpi. Scale bars, 10 µm.

#Coronaviruses remodel host membranes for replication, but which pathways are involved? This study reveals #cholesterol transporter GRAMD1C as a host factor that promotes replication organelle formation and supports replication across multiple coronaviruses @plosbiology.org 🧪https://plos.io/3NQ4FGY

GRAMD1C-mediated cholesterol transport is critical for viral replication. Top: Schematic of cholesterol transport by the GRAMD1C ASTER domain from PM to ER. Bottom: Confocal fluorescence microscopy analysis of the co-localization of TGEV dsRNA (indicated in magenta), ectopic expression of GRAMD1C-HA (indicated in green), and ER-tracker pDsRed2 (indicated in red) in WT cells mock-infected or infected with TGEV (MOI = 0.1), at 12 hpi. Scale bars, 10 µm.

#Coronaviruses remodel host membranes for replication, but which pathways are involved? This study reveals #cholesterol transporter GRAMD1C as a host factor that promotes replication organelle formation and supports replication across multiple coronaviruses @plosbiology.org 🧪https://plos.io/3NQ4FGY

GRAMD1C-mediated cholesterol transport is critical for viral replication. Top: Schematic of cholesterol transport by the GRAMD1C ASTER domain from PM to ER. Bottom: Confocal fluorescence microscopy analysis of the co-localization of TGEV dsRNA (indicated in magenta), ectopic expression of GRAMD1C-HA (indicated in green), and ER-tracker pDsRed2 (indicated in red) in WT cells mock-infected or infected with TGEV (MOI = 0.1), at 12 hpi. Scale bars, 10 µm.

#Coronaviruses remodel host membranes for replication, but which pathways are involved? This study reveals #cholesterol transporter GRAMD1C as a host factor that promotes replication organelle formation and supports replication across multiple coronaviruses @plosbiology.org 🧪https://plos.io/3NQ4FGY

This five-day intensive program brings together early-career scientists and postgraduate students studying #influenza, #coronaviruses, #RSV, and other respiratory viruses. 🦠🐓🧪😷🥼💉🔬

4/ The modification of tRNAs has been observed both in SARS-CoV-2, associated with serious infections, and in HCoV-OC43, which usually causes very mild cold-like signs and symptoms. Therefore, it could be a common strategy among different #coronaviruses.

Identifiquen una diana terapèutica que permetria frenar la propagació dels coronavirus Es tracta d'un enzim que s'activa en les cèl·lules humanes com a resposta a l'estrès degut a la infecció i provoca canvis en la maquinària cel·lular que afavoreixen la producció i la propagació dels c...

1/ 🎯 A therapeutic target that would curb the spread of #coronaviruses has been identified

It is an enzyme that is activated in human cells in response to stress due to infection and causes changes in the cellular machinery that favour the production and spread of coronaviruses
tuit.cat/5y9Rr

The #impact of clade B #lineage 5 #MERS #coronaviruses #spike #mutations from 2015 to 2023 on virus entry and replication competence

The #impact of clade B #lineage 5 #MERS #coronaviruses #spike #mutations from 2015 to 2023 on virus entry and replication competence, etidiohnew.blogspot.com/2026/02/the-...

The recent study “A multi-disciplinary approach to identify spillover interfaces of bat #coronaviruses to pig farms in Italy” by Istituto Zooprofilattico Sperimentale delle Venezie, investigates the potential risk of coronavirus spillover from bats to pigs in intensive farms in Northern Italy.

From #pandemic #influenza to novel #coronaviruses: emerging infectious diseases of the 21st century

From #pandemic #influenza to novel #coronaviruses: emerging infectious diseases of the 21st century, etidiohnew.blogspot.com/2026/01/from...

Structural basis for #human #DPP4 #receptor recognition by #MERS-like #coronaviruses 2014-422 and GX2012

Structural basis for #human #DPP4 #receptor recognition by #MERS-like #coronaviruses 2014-422 and GX2012, etidiohnew.blogspot.com/2026/01/stru...

And it isn’t a hypothetical risk – it’s already happening, as evidenced by the emergence of seven new #coronaviruses from animals since the 1960s. The societal and economic costs of wildlife trafficking are vastly underestimated.

3/

High-Priority Pathogens with Potential to Cause “Disease X” Pandemics A commentary analysing the major features of pathogens with high probability of becoming future pathogen X.

This study analyzes pathogen features for future #COVID-like #pandemics, identifying #coronaviruses and #influenza—as top "disease X" threats due to transmission, animal interfaces, immunity barriers, & mutation rates, with #MosquitoBorneViruses posing high risk.

#OpenAccess: tinyurl.com/269cuzm2

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses Cryopreserved lung-humanized mice overcome the dependency to fresh tissues and permit head-to-head profiling of all four human common cold coronaviruses versus SARS-CoV-2 infection; the model validat...

New in #AdvancedScience: Dual-humanized mouse model with cryopreserved human lung tissue lets researchers study common cold #coronaviruses & #SARS-CoV-2 in a human-relevant way. Opens doors for testing #antivirals and exploring immune responses.
🔗 shorturl.at/CYJZU @wileylifesci.bsky.social

Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions | Journal of Virology Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue to pose a significant risk for future outbreaks through zoonotic transmissions. This highlights the need for effective countermeasures to prevent future pandemics. Whil...

New #paper describes a human #antibody that neutralizes #coronaviruses. Read "Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions" by @sickkidsvs.bsky.social @utoronto.ca using our CMCF beamline. https://bit.ly/3MlPh3G👈

#Pathogenesis and Transmissibility of #MERS #Coronaviruses of African Origin in #Alpacas

#Pathogenesis and Transmissibility of #MERS #Coronaviruses of African Origin in #Alpacas, etidiohnew.blogspot.com/2025/11/path...

Newly discovered host mechanism in coronaviruses A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated…

Newly discovered host mechanism in #coronaviruses ...

| #virus | #kinase | #microscopy | #infections | Via eurekalert .org

HKU25 clade #MERS-related #coronaviruses use #ACE2 as a functional #receptor

HKU25 clade #MERS-related #coronaviruses use #ACE2 as a functional #receptor, etidiohnew.blogspot.com/2025/11/hku2...

🍂The fall🍁issue🍃of ProLOEWE NEWS is out! Featuring the 🆕development of LOEWE @emergencity.de, the #Heinerboxes, a symposium on #coronaviruses by LOEWE-CoroPan that took place at jlugiessen.bsky.social & the 1st🌻Summer🏫 by LOEWE-ADMIT @thm.de @tuda.bsky.social 👉🏼https://proloewe.de/en/proloewe-news/

Novel multiplex family-wide PCR and Nanopore sequencing of amplicons (FP-NSA) approach for surveillance of influenza- and coronaviruses in humans and animals. #Nanopore #AmpliconSequencing #VirusSurveillance #Coronaviruses #Influenza #GenomeBiology 🧪🧬
genomemedicine.biomedcentral.com/articles/10....

While COVID is now generally mild in vaccinated individuals, it still causes substantial morbidity, particularly in vulnerable groups. New variants or other #coronaviruses could still emerge with pandemic potential, highlighting the need for safe, effective & affordable antivirals.

China has 7 major laboratories for studying virology.

Only 1 of them studies #Coronaviruses.

Wuhan Institute of Virology (WIV)

Specialization: High-containment virology (BSL-4/BSL-3), research on weaponizing coronaviruses and viral pathogens (bat coronaviruses, SARS, influenza).

Bispecific inhibitor can combat a wide range of coronaviruses, including Paxlovid-resistant variants A team of researchers have discovered a powerful bispecific inhibitor capable of combating all existing human-pathogenic coronaviruses, including those resistant to existing treatments like Paxlovid.…

Bispecific #inhibitor can combat a wide range of #coronaviruses ...

| #Paxlovid | #variants | #mutants | #pathogen | Via @sciencex.bsky.social

The LOEWE Research Cluster #CoroPan hosted a symposium on 🦠 #coronaviruses on Sept. 23-24, 2025 at
@jlugiessen.bsky.social with inspiring talks from international experts as well as principal investigators and 👩‍🔬👨‍🔬young scientists from CoroPan.
➡️
www.linkedin.com/feed/update/...

📷: Lisa-Marie Seeber

🏁 A good start: Infect-Net members Stefanie Deinhardt-Emmer and Manja Marz proudly introduced the invited lecture by Lia van der Hoek at the 77th DGHM Meeting in Jena. 💜
📸: Vera Voltersen
#DGHM #Infectnet #Coronaviruses #Microbiology

Synchronized seasonal excretion of multiple coronaviruses coincides with high rates of coinfection in immature bats - Nature Communications Bats harbor diverse coronaviruses but temporal dynamics are less well studied. Here, the authors analyzed coronaviruses in Australian flying foxes over 3 years showing peak shedding and co-infections in juveniles and subadults and providing evidence of historical and contemporary recombination between viral clades.

Synchronized seasonal excretion of multiple #coronaviruses coincides with high rates of coinfection in immature bats

@alibat.bsky.social @rainap.bsky.social

#virology #OneHealth #surveillance #epidemiology

Our study describing the isolation and characterisation of contemporary seasonal #coronaviruses is out 🦠🎉🎊 journals.asm.org/doi/10.1128/... Led by @jessneil26.bsky.social at @thedohertyinst.bsky.social

Diversity and #spillover #risk of swine acute diarrhea syndrome and related #coronaviruses in #China and Southeast #Asia

Diversity and #spillover #risk of swine acute diarrhea syndrome and related #coronaviruses in #China and Southeast #Asia, etidiohnew.blogspot.com/2025/08/dive...

The Differences in the Evolutionary #Dynamics of #MERS and #SARS #Coronaviruses

The Differences in the Evolutionary #Dynamics of #MERS and #SARS #Coronaviruses, etidiohnew.blogspot.com/2025/08/the-...

Identification and characterization of novel #bat #coronaviruses in #Spain

Identification and characterization of novel #bat #coronaviruses in #Spain, etidiohnew.blogspot.com/2025/08/iden...

High-Priority Pathogens with Potential to Cause “Disease X” Pandemics A commentary analysing the major features of pathogens with high probability of becoming future pathogen X.

This commentary explores the major characteristics of pathogens with potential to cause disease X, and show that RNA- & vector-borne viruses might become pathogen X, while, #coronaviruses and #InfluenzaViruses represent top-priority #PathogensX.

#OpenAccess: zoonoses-journal.org/index.php/20...