Palindromic rheumatism is unpredictable and under-researched
New study by Chapman et al captures valuable patient insights
➡️ Unpredictable flares & psychological distress
➡️ Frequent diagnostic delays
➡️ Lack of info on progression to RA
@rheumjnl.bsky.social #palindromic doi.org/10.1093/rap/...
Upadacitinib is a Double Edged Vascular Sword in GCA
Dr. David Liew discusses abstracts O751, O738, and O734 presented at #ACR25.
buff.ly/e1fS13D
Latest atlas article out
@rheumjnl.bsky.social Rheumatology Advances in Practice:
Imaging of gout
(an area with lots of nuance)
very pretty images but also lots of great practical hints from Luqman Wali & Emma Rowbotham
Well worth checking out & it's open access: academic.oup.com/rheumap/arti...
The gist:
PMR underserved by Rx, somehow steroid monotherapy accepted as okay
Why? We feel four main reasons:
- myth of self-resolution
- seemingly nebulous presentation
- inadequate pathophys insights
- societal inattention (esp ageism)
snips below but check out full article⬆️
Why does it seem like PMR patients get stuck in situations we would never tolerate for other patients?
@drceowen.bsky.social and I call out many reasons.
PMR is killing them softly, and will continue to do so if collectively we neglect it.
now out @thelancetrheum.bsky.social:
t.co/wMOy9ZEzw4
NEW RESEARCH—Sarilumab in relapsing polymyalgia rheumatica: patient-reported outcomes from the phase 3 SAPHYR trial bit.ly/4k0mlJQ
Plus linked Comment by @drdavidliew.bsky.social &
@drceowen.bsky.social bit.ly/4eiha6W #Medsky #Rheumsky
Sometimes you hear:
“PMR dose steroids don’t really matter”
Errrrr…
(You wouldn’t accept this steroid exposure in any other disease. Never)
#EULAR2025 POS0139 @rheumnow.bsky.social
Fast track PMR clinics in Denmark led to more patients seen, and time to referral went down.
If we don’t get in early with a right diagnosis (and maybe early steroid-sparing) then PMR patients deteriorate.
We shouldn’t let PMR be an end stage disease #EULAR2025 POS0136 @rheumnow.bsky.social
Oh and in case you’re forward planning to #EULAR2026 - it’s London, 3-6 June. Right now it might be just the start of #EULAR2025, but start your trip planning now! @RheumNow
IL-17 inhibition for PMR?
In the secukinumab ph2 in GCA (TitAIN), patients with PMR did really well, seemingly outperforming steroid taper in the placebo arm. Real promise, will be great to see how the ph3 in PMR (REPLENISH) goes
OP0062 #EULAR2025 @rheumnow.bsky.social
What’s worse for infection in GCA: tail end steroid taper, or a JAK inhibitor?
This is exactly SELECT-GCA in the second 6mo. What happened?
upa skews better on serious infection, worse on HZ
JAKi might have infection risk, but not like steroids. OP0057 #EULAR2025 @rheumnow.bsky.social
Here in Barcelona, and back at it for the @RheumNow team! Bring on #EULAR2025 and all the great rheumatology here
Of course with the dynamic team of @synovialjoints @Yuz6Yusof @DrMiniDey @AurelieRheumo @AdelaCastro222 @JihaRheum @Nellziade and the one and only @Janetbirdope
GCA finally gets a second option, eight years after the first!
Choice means more people can get benefit, but also that we can start to look at strategy - something we badly need for both GCA and PMR.
Text message reminders targeting patients who delay refilling their cardiovascular medications did not improve medication adherence based on pharmacy refill data or reduce clinical events at 12 months.
ja.ma/4irtinM
Ozempic will change rheumatology
Ozempic's presence is widespread, even reaching Australia, despite limited supply and advertising restrictions. Its American ad jingle is known here, highlighting its significant cultural impact and ubiquitous brand recognition.
The Case for JAKi in PMR
Dr. David Liew abstract 0858, Baricitinib in Early Polymyalgia Rheumatica (BACHELOR Study), presented at #ACR24.