Excited we can generate nephron cells for preclinical trials. We will continue to perfect the proximal tubule model and are going deep into understanding nephron injury programs and following up on druggable targets that could solve acute kidney injury and maladaptive repair.

Mostly, just advertising Jack Schnell's* impeccable taste in figure color choices. *soon to be first set of Ph.D. graduates from lab @lindstromlab.bsky.social. Here he describes the development of nephron cells in stem cell derived kidneys.

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers Current human pluripotent stem cell-derived kidney organoids contain nephron-like structures that lack organotypic patterning. It is thought that during human development, nephrons form their proximal...

Recent preprint with @leonardomorsut.bsky.social. We perform detailed spatial transcriptional analyses of human kidney development to resolve how nephrons pattern, and build synthetic cell organizers to copy axial patterning using stem cells derived nephrons. www.biorxiv.org/content/10.1...

A fluorescently stained kidney organoid made from stem cells. It shows cells and nuclei that are the precursors of potassium reabsorbing cells in the adult nephron.

Happy holidays! A very cool looking kidney organoid, courtesy of senior Ph.D. student MaryAnne Achieng in the @lindstromlab.bsky.social.

Modelling human brain development and disease with organoids Nature Reviews Molecular Cell Biology - This Roadmap article discusses recent advances in the production and use of brain organoids to understand brain development and associated disorders. The...

So excited to share our new @natureportfolio.bsky.social review on modeling human brain development using organoids! 🧠 Loved collaborating with the brilliant @lancasterlab.bsky.social , led by the incredible @marcellabirtele.bsky.social Check it out! 🔬 #Neuroscience #BrainOrganoids rdcu.be/d3llp

Want to highlight how a really fun collaborative project, Nils is as close as it gets to the prototypical omniscient kidney developmental biologist, it was so fun to learn from him about this fascinating developmental system. @lindstromlab.bsky.social

It has been such a fun project to work on and the collaboration with your lab has just taken it to a different level - great to work with true synbio magicians! I am now more convinced than ever before that artificial organs of the future will rely on synthetic inputs that tune self-organization.

Generation and long-term culture of human cerebellar organoids from pluripotent stem cells Nature Protocols - Generation and long-term culture of a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicates the cellular diversity of the fetal...

We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social