This is so fun!

Congratulations to Dr. Chris Kassotis, winner of the 2024 Lou Guillette Jr. Outstanding Young Investigator Award! @cdkassotis.bsky.social
heeds.org/2024-lou-gui...

Thanks so much, Angel!!

Reducing Exposures to Endocrine Disruptors (REED) study, a personalized at-home intervention program to reduce exposure to endocrine disrupting chemicals among a child-bearing age cohort: study protoc... Background Exposures to endocrine disrupting chemicals (EDCs) have been linked to chronic diseases including breast cancer, metabolic syndrome, diabetes, and infertility. Exposure during pregnancy may...

Cool new trial by @millionmarker.bsky.social on reducing EDC exposure:

trialsjournal.biomedcentral.com/articles/10....

Also if any of the above links do not work, you can always find free full-text versions of any papers we publish on our lab website! Reach out with any/all comments and questions! #toxicology #toxic #chemicals #health

www.kassotislab.org/publications...

Co-treatment with thyroid hormone did alleviate some of the metabolic health effects in cells, though we also found that these chemicals did not directly bind TR. They do interfere with co-regulatory protein recruitment, a likely mechanism mediating the thyroid receptor effects.
More to come!

Our newest paper, led by my postdoc, Dr. Roxanne Bérubé, dug into mechanism to try and find what pathways these chemicals disrupted, using both human and zebrafish cell assays. We honed in on thyroid receptor inhibition as a likely mechanism.
academic.oup.com/endo/article...

Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish Alkylphenol polyethoxylates (APEOs), such as nonylphenol ethoxylates (NPEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations, textile ...

We followed that up by confirming this concept in zebrafish. Two publications demonstrated that both the "legacy" polyethoxylates as well as some of the newer "environmentally friendly" alternatives promoted adiposity.
Here: www.mdpi.com/2305-6304/10...
Also here: www.mdpi.com/2218-1989/13...

We've previously shown that they promoted fat cell development in cells - both promoting lipid accumulation and fat cell differentiation and also expanding the pool of fat cells by driving proliferation of pre-adipocytes. You can read some of that work here:

academic.oup.com/toxsci/artic...

Our latest lab work is centered around polyethoxylated surfactants, ubiquitous chemicals used in hard surface cleaners and detergents. They're found everywhere we look - household dust, wastewater, surface water, even drinking water. Probably almost everyone uses some of these chemicals every day.

Endeavoring to be more active on this platform!

I manage an endocrine disruption lab at Wayne State University in Detroit, MI.

We study how diverse environmental pollutants (and mixtures of them) can disrupt our hormones and contribute to chronic disease. Will share more in the coming weeks!

Great day at Michigan Society of Toxicology meeting! Fantastic keynotes from Cheryl Murphy, Nishad Jayasundara, and Scott Belcher. Tons of great Wayne State presentations, from our group in IEHS and Pharmacology, and also Bio Sci, & Pharm Sci!
#misot #toxicology #EDCs #health #chemicals