Great summary by @philipcball.bsky.social! Our findings certainly don’t invalidate the central dogma, but rather demonstrate an unexpected (and cool!) structural mechanism by which a sequence-specific DNA is created in a cell. (1/6)
Such an exciting time to be in neuroscience. To study how animals do the amazing things they do: from collective behaviors to navigation, camouflage and more. How can we define the constraints of a sensory system if we don't study diverse animals and their behaviors?
Oh and #fundscience.
!
Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation
www.pnas.org/doi/abs/10.1...
Will someone give this man a Faculty job already?! #AskingForAFriend
It’s so beautiful to read these stories. I’m happy to know there are so many thoughtful PIs out there. We need more of them to make science a better place! www.nature.com/articles/d41...
Irini Topalidou received the GSA Mentorship Award for her contributions to mentoring in the C. elegans field. genestogenomes.org/being-a-staf...
Congratulations to all the awardees and stay tuned for more profiles of 2026 GSA award recipients!
Judith Kimble received the Thomas Hunt Morgan Medal for her work on discovering the first stem cell niche and lifetime achievement in genetics. genestogenomes.org/a-lifelong-q...
Whole-organism spatial transcriptomics at single-cell resolution in C. elegans #SingleCell 🧪🧬🖥️
www.biorxiv.org/content/10.64898/2026.04...
Analysis of Nematode Ventral Nerve Cords Suggests Multiple Instances of Evolutionary Changes to Neuron Number
onlinelibrary.wiley.com/doi/10.1111/...
New preprint!
"A stereotyped glial attachment determines the morphology and function of neuronal cilia"
doi.org/10.64898/202...
We find that C. elegans neuronal cilia attach to glia, we identify a protein required for cilia-glia attachment, and we show that glial attachments alter cilia signaling.
New paper alert: Our latest shows how maternal diet impacts ribosome levels and early growth intergenerationally in #Celegans
Led by Sigma Pradhan and in collab with @nstroustrup.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org @izb-unibern.bsky.social @unibe.ch
The next Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar will be held this Friday, April 10 at 3 pm Eastern Time. It will feature Joaquín Navajas Acedo (Biozentrum at the University of Basel) and Yiqun Wang (University of California, San Diego). The SDB Ethel Browne Harvey Postdoctoral Seminar Series is free and open to anyone interested in developmental biology and supporting the great work our postdocs are doing. Speakers Headshot of Joaquín Navajas Acedo Joaquín Navajas Acedo Biozentrum at the University of Basel "Spatiotemporal emergence of somatosensory neuron diversity in zebrafish" Headshot of Yiqun Wang Yiqun Wang University of California, San Diego "Asymmetric mRNA partition mediated embryonic patterning in spiralian development revealed by spatial transcriptomics"
Look out world--check out these great upcoming talks!
The worm community has lost a true legend with the passing of Don Moerman. Don's impact on C. elegans research is beyond measure. A friend to many of us here in MN, his work has been invaluable, contributing >5,400 strains (VC & DM) to the CGC, 20% of our collection!
“first drafts of Results, Discussion, and Introduction should be the trainee’s own work. AI can help with grammar…tightening prose…critiquing the logic of an argument you’ve already made. But the hard part of forming the argument needs to be yours.’ blekhman.substack.com/p/you-need-t...
Issue 6 is now complete!
On the cover: Fluorescence micrograph of a Caenorhabditis elegans gonadal region showing the spermatheca (cyan) and adjacent syncytial gonad (magenta). For more details, see Chan et al.
journals.biologists.com/dev/article/...
Rethinking mitochondrial heteroplasmy: selection, conflict and adaptation
royalsocietypublishing.org/rstb/article...
Great to see this out. Practical guidance on how to use protein depletion systems in C. elegans
It is so exciting that Judith Kimble received this recognition by her fellow geneticists!
When I was a new grad student, Judith's papers were a big influence on how I learned to think about what is a scientific problem, and ever since I've tried to follow her paper's aesthetics. 1/
Congratulations to the legendary scientist Judith Kimble!!!
We stand on the shoulders of giants.
#womeninSTEM #celegans
⚒️ NEW TOOLBOX for #Celegans researchers 🪱
Theresa Gibney and Ariel Pani developed a method that allows for a standardized workflow to generate N-terminal and internal tags in any background and without the need for genetic balancers.
Paper in #GENETICS:🔗 buff.ly/wXMml3x
A modular bacterial platform for tunable double-stranded RNA delivery and RNA interference in nematode Caenorhabditis elegans www.biorxiv.org/content/10.64898/2026.03...
Sensory and developmental phenotyping of C. elegans parses autism associated genes into behavioural classifications www.biorxiv.org/content/10.64898/2026.03...
Guangshuo Ou's lab is a powerhouse. Here they create a C. elegans mutant collection to model human disease variants of uncertain significance.
The limitation section raises the challenge of storing & sharing strains. The NIH funds the CGC. How can we build international resources w/cost sharing?
Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources. www.life-science-alliance.org/content/9/6/...
Many congratulations @farmgirlphd.bsky.social! Well deserved! We'll celebrate at the next small RNA meeting!
A question for biologists: we often talk about evolutionary novelty. What does “novelty” mean for you? What’s your favorite definition if any? Or just a rule of thumb for what is and isn’t novel.
Figure 1
LIVEtools: an R Package for Visualizing C. elegans Embryo Cell Tracking Data #micropublication #biology #data #caltechlibrary #Celegans #Software #PhenotypeData #Methods #ImagingSoftware #ExpressionDa micropublication.org/journals/biology/micropu...
