Our recent preprint on how elevated temperatures affect early embryo development. We are using fly embryos to address this fundamental question, and seeing mitotic defects, which can be rescued to improve embryo survival.
doi.org/10.1101/2023...
A mechanical puzzle solved: @lepuslapis.bsky.social and @zhaoshh.bsky.social lay the foundations for mechanical instabilities on curved surfaces. @mpi-cbg.de @mpipks.bsky.social @csbdresden.bsky.social, publication in @physrevlett.bsky.social: www.mpi-cbg.de/news-outreac...
Missing also @bipashadey29.bsky.social, but with @sameerthukral.bsky.social crashing the party, more than making up for it!
Happy to have shared my first post on The Node, on how hidden power dynamics may prevent creative science from blooming.
@the-node.bsky.social
thenode.biologists.com/the-invisibl...
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
Super thrilled to see our review out! It was a great experience to put this together with @sameerthukral.bsky.social and @yuchiunwang.bsky.social. Use it as a primer to the field or as inspiration to brainstorm how rigidity transitions can bridge scales!
Final thanks to reviewers @amartinezarias.bsky.social @thibautbrunet.bsky.social & Cassandra Extavour and the editor @endofthepier.bsky.social. Quest for the mysteries of #cephalicfurrow and #Evolution_of_Morphogenesis continues (9/9)
Our heroes: Bipasha Dey in my lab, Verena Kaul and @girishkalephd.bsky.social in Steffen's lab. PI search committees: be on the look out for Bipasha and Girish. They do wonders. But not after Bipasha does some additional cool things with Pavel. Stay tuned! (6/9)
Two distinct solutions, out-of-plane deformation and out-of-plane division, prevent mechanical instabilities. Our paper www.nature.com/articles/s41...; Pavel's and @bruvellu.bsky.social's with beautiful HCR in situ, lightsheet and @carldmodes.bsky.social's model www.nature.com/articles/s41... (5/9)
In Steffen's lab, @girishkalephd.bsky.social and Verena went out of their way to heroically sample much expanded range of fly phylogeny. #cephalicfurrow and lack there of split neatly along the divide of cyclorrhapha/non-cyclorrhapha. (4/9)
#cephalicfurrow forms and retracts to prevent tissue collision. Blocking it optogenetically not only causes buckling during #gastrulation, it also causes specific defects several hours after normal timeframe of retraction. More mysteries yet to be solved! (3/9)
Where to start?
Beautifully concise, yet comprehensive N&V by @thibautbrunet.bsky.social
www.nature.com/articles/d41...
Essential reading from Pavel himself: tinyurl.com/4vurwar2
A thread of our bioRxiv from the other platform:
tinyurl.com/46ceutx9
But read on for new stuff from revision! (2/9)
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
