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Posts by Chaitanya Dingare

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Happy to share this work from @alexneaverson.bsky.social where she has dissected the timing and relative contribution of the organiser and its derivates to multiple aspects of early neural development:

www.biorxiv.org/content/10.6...

4 weeks ago 45 13 1 0

Congratulations! Fantastic news! Hope to see you in Freiburg at some point.

4 weeks ago 1 0 0 0
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Frenster Lab | Cell Competition Dynamics We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...

The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com

4 weeks ago 71 19 11 3
Evo-Devo-Tempo Lab

Very happy to announce that I will be joining the Faculty of Biology & @cibss.bsky.social at @uni-freiburg.de as an Emmy-Noether funded group leader.

We will tackle the molecular and genetic basis of developmental timing and size control using diverse Oryzias species. We are hiring at all levels !

4 weeks ago 69 15 16 3
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Hi bsky!

How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!

(@bensteventon.bsky.social lab)

tinyurl.com/2ncc8zap

4 months ago 26 10 0 1
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Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...

Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...

5 months ago 6 2 0 0
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Single-nucleus profiling highlights the all-brain echinoderm nervous system A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.

Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...

5 months ago 60 27 4 3
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Hi bsky!

Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!

w/ A. Delahaye & ‪@bensteventon.bsky.social‬

shorturl.at/v01DO

8 months ago 55 17 1 1
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Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?

I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.

5 months ago 37 14 1 2
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Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm.

bsky.app/profile/epim...

5 months ago 7 2 1 0
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Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - Nature Biotechnology A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.

Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8

5 months ago 11 1 2 1

Congratulations Ahmed and colleagues in the @niakanlab.bsky.social on this beautiful work tracking mitotic errors by live imaging the human embryos!

5 months ago 1 1 0 0
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MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com

Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b

5 months ago 3 2 0 0
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A developmental atlas of zebrafish gills links early vascular patterning to adult architecture

Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:

journals.biologists.com/dev/article/...

6 months ago 35 11 1 1

Congratulations @vlecaudey.bsky.social @mathpreu.bsky.social

6 months ago 2 0 1 0

Congratulations!

7 months ago 2 0 1 0
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1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...

#DevBio #Zebrafish

7 months ago 56 27 4 2

New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!

7 months ago 3 2 0 0
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Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...

7 months ago 17 5 3 0

This is a rigorous piece of work, completed with help of current @vlecaudey.bsky.social lab members.

7 months ago 1 0 0 0

I combined the genetics with live imaging approaches to delineate how hippo pathway and its regulators control the cell number. I have generated a few essential tools including the zebrafish specific yap1 antibody (works really well).

7 months ago 1 0 1 0

I have used the zebrafish lateral line primordium as a model. Reason - it contains only 100-120 cells to begin with so much easier to follow the mechanisms that controls the cell number.

7 months ago 0 0 1 0
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Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...

www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.

7 months ago 5 1 1 0

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration www.biorxiv.org/content/10.1101/2025.09....

7 months ago 2 2 0 2

@vlecaudey.bsky.social !

7 months ago 0 0 0 0
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Congratulations!

8 months ago 1 0 0 0
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Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

9 months ago 114 38 18 3
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

Nerve-to-cancer transfer of mitochondria during cancer metastasis
www.nature.com/articles/s41...

9 months ago 11 4 0 0

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling www.biorxiv.org/content/10.1101/2025.06....

9 months ago 3 1 0 0

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning www.biorxiv.org/content/10.1101/2025.06....

9 months ago 3 3 0 0