Tumour promotion through the lens of evolution Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

Tumor promotion through the lens of evolution

This review grew out of many long conversations, shared ideas, and lively discussions

It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk

rdcu.be/fdC2J

Meet our exceptional training team for #CancerEpi2026 💫

Field experts will guide you through how to use the best genomics tools and approaches to detect cancer mutations.

🗓️ 16-18 February 2026
Apply by 3 November - bursaries available

📎 bit.ly/41mRDnD
#OncSky #GeneSky #CancerSky 🧪🖥️🧬

📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!

Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...

#Epigenetics #Cancer #EwingSarcoma

Huge thanks to the team!

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!

⬇️More info⬇️

Ultra-sensitive DNA sequencing maps mutations that precede cancer Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer

go.nature.com/42vakWS

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

✍️ #IRBBarcelona & University of Washington

➡️ bit.ly/42wcIN5

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧵👇

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.

Read more: www.cancergrandchallenges.org/news/early-c...

Wellcome Connecting Science Cancer Genomic Epidemiology 2026 Course dates: 16-18 February Location: Wellcome Genome Campus, UK Application deadline: 3 November 2025 Apply now Image description: A group of course participants seated in a classroom. A speaker is standing at the front of the room, holding a microphone, and is addressing the room.

Join us for hands-on training in Cancer Genomic Epidemiology! #CancerEpi2026

Gain the expertise to use the tools and approaches to detect cancer mutations, and inform equitable prevention.

🗓️ 16-18 February 2026
Apply by 3 November - bursaries available

📎 bit.ly/41mRDnD
#OncSky #GeneSky 🧪🖥️🧬

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

Kudos to @raquelbmi.bsky.social and @ferriol.bsky.social, first authors of the study, for the insane amount of good work put into this.

Bioinformatics Software Developer in Cancer Genomics (ref. LAB/25/06) - IRB Barcelona IRB Barcelona is seeking a talented and motivated Bioinformatics Software Developer (Research Assistant) to join the Biomedical Genomics Lab led by Dr. Núria López-Bigas at IRB Barcelona (bbglab.ir...

We are searching for a Bioinformatics Software Developer to work in Cancer Genomics:
recruitment.irbbarcelona.org/jobs/5793638...

The BioGenome Portal: a web-based platform for biodiversity genomics data management Abstract. Biodiversity genomics projects are underway with the aim of sequencing the genomes of all eukaryotic species on Earth. Here we describe the BioGe

🚀 Our new paper is out! The BioGenome Portal: an open-source customizable platform for managing biodiversity genomics data 🧬🌍

doi.org/10.1093/narg...

@crg.eu @rodericguigo.bsky.social

#genomics #biodiversity

Will the world of short-read Next-Generation Sequencing change forever? We are about to find out! #Roche #SBX #ShortReads #NovaSeqKiller

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

“The leaders of the Human Genome Project always knew they were just starting a conversation”

The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do

https://go.nature.com/3CupmSS

Banner for job offers

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.

PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB

RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs

We recently announced a dual new release of intOGen and boostDM

Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations

➡️ Compendium of Cancer Driver Genes - www.intogen.org

➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm