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Posts by Dr Ellen Knuepfer

Video

“I think it’s a real mistake to forget where the pipeline for all this begins.”

John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it.
www.crick.ac.uk/news/2026-03...

4 weeks ago 81 37 3 5

Superb. Highly deserved Maryse.

1 month ago 1 0 0 0
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Structure-guided design of a PfCyRPA-based vaccine against blood-stage malaria - EMBO Molecular Medicine Effective vaccines against malaria are urgently required. All components of the PfPCRCR complex are essential for erythrocyte invasion by Plasmodium falciparum and are potential vaccine immunogens aga...

This immunogen is cheap and easy to produce and elicits a high quality antibody response. Project led by @nawsadalam. Read all about it:
link.springer.com/article/10.1...

1 month ago 5 2 0 0

New work out, with webtool to compare P. #knowlesi and P. #vivax temporal expression of the IDC (orthologs, or any gene of interest)🔥🔥
Reconfirming the suitability of Pk A1H1 as a model for Pv!

2 months ago 3 1 0 0
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Scientists reveal how sleeping sickness parasites control their surface coat Researchers have revealed how parasites hide thousands of antigens behind a single-colour coat and how disrupting this control could make the parasit...

New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion.

@tiengwe-tryplab.bsky.social
@zephyris-science.bsky.social
@fariatrypslab.bsky.social

www.imperial.ac.uk/news/article...

2 months ago 12 9 0 0
Video

Are you a highly motivated molecular parasitologist excited to study how Plasmodium parasites invade red blood cells?

Come and join our collaborative Wellcome Trust-funded project!
We have two 3-year postdoc positions available. 👇🏻

jobs.rvc.ac.uk/Vacancy.aspx...

2 months ago 0 0 0 0

Excited about parasites? Love watching movies? Come join our Wellcome-funded project! Parasitology friends, please do share far and wide.

2 months ago 5 8 0 1
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Check out our latest study on the PfRIPR protein,
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.

3 months ago 16 9 2 0

Superb! Well done. Cannot wait to explore the data.

4 months ago 0 0 0 0

Here is hoping that been given a new opportunity, finally, the courage is there within the directive of the Royal Society to do the right thing.

7 months ago 0 0 0 0

It is a stain on a world-leading institution. Would the decision to expel a fellow been more forthcoming if the person wasn’t as rich and politically influential (?still)? Sometimes in life you have to show courage because it is the right thing to do. This is one of these situations!

7 months ago 10 1 2 0

A reminder that Elon Musk is still a Fellow of the Royal Society. Surely THIS is the point at which he is expelled @royalsociety.org

7 months ago 119 56 3 41

Well done Bishara!

8 months ago 0 0 0 0
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Happy to share that the #KnuepferLab has initiated change in culture at the #RoyalVeterinaryCollege as the first lab to participate in the lab sustainability challenge, LEAF. Onwards and upwards!

8 months ago 3 0 0 0
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The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

8 months ago 54 19 7 6
Postdoctoral Research Associate We are looking for a talented and enthusiastic Postdoctoral researcher to join the Young lab to investigate secreted proteins during chronic Toxoplasma gondii infection.

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

9 months ago 8 7 0 1
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Congrats Matts!

9 months ago 1 0 0 0

😉

10 months ago 0 0 0 0

Fantastic discovery. Beautiful work! Well done the whole international team. @parasitematt.bsky.social
When are you coming to the RVC to give a talk now @sam-chamberlain.bsky.social ?

10 months ago 2 0 1 0
GIMM PhD Studentships 2025 – GIMMGIMM PhD Studentships 2025 – GIMM Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!

GIMM PhD Programme now open. 17 PhD positions and a few more to come.

gimm.pt/course/phd-p...

10 months ago 1 2 0 0
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Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us!
www.bioch.ox.ac.uk/studentships

10 months ago 8 7 0 0
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Nawsad presented our structure-guided design of RH5top, our latest blood stage-malaria vaccine immunogen, in talk and poster at the Malaria Gordon conference. The culmination of many studies from the lab and collaborators and doing well in pre-clinical testing! More soon.

10 months ago 19 4 0 0
Postdoctoral Research Associate This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...

Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

11 months ago 15 23 2 0
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The KnuepferLab is hiring!

Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.

Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...

11 months ago 13 16 1 2

Hear, hear.

11 months ago 0 0 0 0
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Fossils of Mesozoic monotremes are VERY rare so this is a big deal. I'm not aware of other Mesozoic monotreme postcrania. Just jaws/?skull bits and teeth.

11 months ago 6 1 0 0
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Researchers uncover how intestinal parasite Cryptosporidium alters host cells Researchers at the Francis Crick Institute have shown that the Cryptosporidium parasite exports a protein into infected intestinal cells, altering the gut environment and enabling the parasite to surv...

Crick researchers have uncovered how the intestinal Cryptosporidium parasite uses a protein to alter its host’s gut environment, enabling the parasite to survive and replicate.

www.crick.ac.uk/news/2025-04...

11 months ago 35 12 2 0
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Keep VEuPathDB open-access to all by subscribing today! veupathdb.org/veupathdb/ap...

1 year ago 16 16 1 3

So important trying to save this critical resource especially as infectious disease biology appears under threat. Credit card payment options to contribute trying to keep Veupathdb alive are almost ready, I hear.

11 months ago 3 2 0 0

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

1 year ago 51 44 9 0