Beyond Viral Suppression: How the Right HIV Drug Helps the Gut Heal Itself Can specific HIV drugs heal the gut? For late-stage patients, viral suppression isn't enough to stop chronic inflammation. Our 2-year trial reveals that dolutegravir, unlike darunavir, profoundly restores the gut microbiome, offering a new pathway to long-term health and reduced inflammation.

Beyond Viral Suppression: How the Right #HIV Drug Helps the Gut Heal Itself

@rutgerwalls.bsky.social @fcatalamoll.bsky.social @irsicaixa.es @hospitalclinic.bsky.social
#Microbiome

Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial - Nature Communications Advanced HIV-1 infection is associated with gut dysbiosis, and it’s not known whether this is reversed with antiviral therapy. The ADVANZ-4 MISTRAL trial shows that dolutegravir restores gut microbiota in late-stage HIV1 patients better than darunavir, and that recovery is linked to improved immune reconstitution.

Clinical trial: dolutegravir restores gut microbiota in late-stage HIV-1 patients better than darunavir, linked to improved immune reconstitution

@rutgerwalls.bsky.social @fcatalamoll.bsky.social @irsicaixa.es @hospitalclinic.bsky.social

Opinion | The $1.3-Million-a-Minute War

The $1.3-Million-a-Minute War www.nytimes.com/2026/03/21/o...

#naturecommunications | Roger Paredes Today we publish in #NatureCommunications evidence that dolutegravir, unlike darunavir, helps restore the gut microbiome in people presenting late with HIV In our multicentre, open‑label RCT (96 week...

www.linkedin.com/posts/roger-...

Europa urge a vacunar sin demora contra la gripe por la rápida expansión de la variante K La nueva variante parece combinar alta capacidad de contagio y riesgo elevado de complicaciones graves

Europa urge a vacunar sin demora contra la gripe por la rápida expansión de la variante K www.lavanguardia.com/ciencia/2025...

New JID supplement explores PEPFAR's infrastructure investments and their impact on global health security. Essential reading for global health policy experts and infection control professionals.

Available now ↪️ https://bit.ly/46mTcVG

Exploring Barcelona's Architecture Through a Mathematical Lens A virtual tour of the architecture in a city where mathematics and exploration meet.

Barcelona Is Made of Math www.nytimes.com/interactive/...

Extending nirmatrelvir–ritonavir treatment beyond 5 days resulted in a nominal improvement in the frequency of viral rebound and was generally well tolerated.

i.e: proportion of randomly assigned and dosed participants with sustained nasopharyngeal SARS-CoV-2 RNA concentrations below the lower limit of quantification (2·0 log10 copies per mL) from days 15 to 44.

Extended nirmatrelvir–ritonavir treatment durations for immunocompromised patients with COVID-19 (EPIC-IC): a placebo-controlled, randomised, double-blind, phase 2 trial Nirmatrelvir–ritonavir is approved for adults with mild-to-moderate COVID-19 who are at risk of severe disease. There are little clinical data to guid…

In this placebo-controlled, randomised, double-blind, phase 2 trial we publish today in Lancet Infectious Diseases, no difference was observed between three nirmatrelvir-ritonavir treatment durations (5, 10 and 15 days) in the primary endpoint, i.e:

www.sciencedirect.com/science/arti...

New paper out: the largest and most international paper to date on clustering of #longcovid patients 🧪 @ndorms.bsky.social @ox.ac.uk
www.jclinepi.com/article/S089...

Se presenta IRIS, el nuevo instituto de referencia en investigación e innovación en salud de la UPC El 5 de junio se ha presentado el Instituto de Investigación e Innovación en Salud (IRIS) de la UPC, que da continuidad al Centro de Investigación en Ingeniería

Es presenta l'IRIS, el nou institut de referència en recerca i innovació en salut de la #UPC

✅ Integrarà 12 grups de recerca acreditats i més de 170 investigadors i investigadores, ubicats en 5 campus de l'àrea metropolitana de Barcelona.

www.lavanguardia.com/launi/202506...

One Hundred Days, Incalculable Losses Emily J Erbelding, M.D., M.P.H; One Hundred Days, Incalculable Losses, The Journal of Infectious Diseases, , jiaf317, https://doi.org/10.1093/infdis/jiaf31

One Hundred Days, Incalculable Losses

Emily Erbelding (NIAID/NIH)

"Every day brought more chaos."

Termination of training grants reflected "an intentional choice to lose a generation of scientists. Recovering from [this]... will take years and probably decades."

academic.oup.com/jid/advance-...

When will we ever learn?

Thank you Dr Yamey

I’ve always believed that parents who allow their kids (which are the most precious and beloved treasure they have) to enroll in a first ever trial are the most honorable individuals in our society. I can’t think of a greater commitment to our common good. Honor to all the Yameys in this world!

Ciència - Acord de l'OMS per a les malalties infeccioses Ciència - Acord de l'OMS per a les malalties infeccioses

🎙️ En @rutgerwalls.bsky.social, director científic de la Fundació, explica a "La primera pedra" de @rac1oficial.bsky.social l’impacte de l’acord de l’OMS per a la lluita contra les malalties infeccioses.

#SalutGlobal #Infeccions #OMS @who.int

www.rac1.cat/a-la-carta/d...

Opinion | Silicon Valley Is at an Inflection Point

www.nytimes.com/2025/05/30/o...

HHS cancels nearly $600 million Moderna contract on vaccines for flu pandemics HHS has notified Moderna that it is canceling a nearly $600 million contract for vaccines for flu strains that could trigger future pandemics.

BREAKING: In a serious blow to US pandemic flu preparedness, HHS has cancelled a contract with Moderna to test and license prototype vaccines for #H5N1 #birdflu and other potential pandemic viruses.
In a pandemic, mRNA is the fastest way to vaccine doses. www.statnews.com/2025/05/28/m...

U.S. aid helped two African countries rein in HIV. Then came Trump In Lesotho and Eswatini, treatment and prevention cutbacks are hitting pregnant women, children, and teens especially hard

Many thanks to @pulitzercenter.bsky.social for making this possible. And of course to my fabulous editor, @martinenserink.bsky.social.
www.science.org/content/arti...

Latest Covid variants and outlook for UK summer There probably will be a Covid summer wave.

Quick COVID update from me discussing latest variants and prospects for summer here.

open.substack.com/pub/christin...

Member States approve WHO Pandemic Agreement in World Health Assembly Committee, paving way for its formal adoption World Health Organization Member States, meeting today in Committee A of the World Health Assembly, approved a resolution that calls for the adoption of an historic global compact to make the world sa...

WHO Member States, meeting today in Committee A of the #WHA78, approved a resolution that calls for the adoption of a historic global compact to make the world safer from future pandemics.

Read: bit.ly/4kjM6p4

A truly historic evening at the #WHA78: the #PandemicAccord resolution was approved in Committee A with 124 in favour, 0 against and 11 abstentions.

The final step: adoption in plenary tomorrow morning.

My thanks once again to @who.int Member States for choosing to keep the world safer. 🙏

We find that the closest-inferred ancestors of SARS-CoV-1 likely circulated in western China (Yunnan, Sichuan, or Guizhou), and that of SARS-CoV-2 in Yunnan, China, or Northern Laos, overlapping with contiguous karst and cave landscapes extending through these regions.

Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at
@yalemed.bsky.social.

Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies 👇🏼👇🏼

No one can ban a rainbow
#DEIintheSky

Retweeting again in the hopes that members of the media can use this awesome resource when they report on vaccines and calls for "new" placebo controlled trials. @statnews.com @nytimes.com @washingtonpost.com @carlzimmer.com @apoorvanyt.bsky.social

Prof Anna Goodman, UK SNAP lead, will be sharing final results at this meeting. Don’t miss out #IDSky Virtual & in person options available

“We must actively challenge policies that seek to suppress knowledge, advocate for continued access to research funding, and support journals and institutions that prioritize evidence-based, apolitical dissemination of science. “

Scientific Integrity Under Threat: The Role of the IDSA, PIDS, and SHEA Journals in an Evolving Political Landscape The landscape of scientific publishing, education, and healthcare research is facing unprecedented challenges as political decisions increasingly encroach

Proud to be part of this family. Thank you editors-in-chief

“The current climate demands that we, as scientists, educators, and healthcare professionals, remain vigilant and vocal in defending the principles of scientific integrity and global health equity.” (…)

academic.oup.com/jid/advance-...