Happy International Woman's Day!!! Wszystkiego najlepszego z okazji Dnia Kobiet!!!

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.

www.nature.com/articles/s41...

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.

Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!

#Pericyte #PulmonaryHypertension
1/2

A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH

#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable,...

www.embopress.org/doi/full/10....

Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states Niethamer, Morrisey, and colleagues delineate the temporal sequence of mouse lung regeneration in a single-cell RNA-sequencing atlas detailing each cellular compartment’s response to influenza infecti...

www.cell.com/cell-stem-ce...

Congratulations Stefano!!!