GPCR-selective effects of endocytosis on cellular signaling through the cAMP / PKA cascade Many GPCRs use endocytosis to promote gene transcription by prolonging signaling through the Gs-coupled cAMP / cAMP-dependent protein kinase (PKA) cas…

New publication! Here, we explore how endocytosis differentially sculpts signaling downstream of three endogenously co-expressed GPCRs: www.sciencedirect.com/science/arti...

Members of the UMN Twin Cities AAUP voted unanimously to endorse this Statement of Solidarity with Somali and Immigrant Communities drive.google.com/file/d/1WDWq...

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.

Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

Now online @nature.com!

Want to change the consequences of receptor activation?

Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥

So many new possibilities! 🧪🧠🟦

www.nature.com/articles/s41...

🧵👇

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

🚀 Hey #GPCR community on #bluesky!

🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬

📅 Nov 12–14, 2025

This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR!

#GPCRforum #ScienceTogether

Emerging Voices in GPCR Biology

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.

www.sciencedirect.com/science/arti...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc

An illustration of a person standing at the top of stairs that end, with text: To increase diversity in STEM, a foot in the door isn’t enough. We need better support.

"Talent and grit matter, but so do structure, transparency, and care." #ScienceWorkingLife https://scim.ag/4nCiPYg

Flyer How to apply to the NSF-GRFP (in 7 weeks!). Check out our comprehensive guide and timeline for applying to the NSF-GRFP (or any fellowship!) on a deadline. Give it a shot — it’s not too late! Resource by Olivia Goldman, PhD and John Lê. Photos of authors. Cientifico Latino, Inc. logo. Link: cientificolatino.com/apply-in-7-weeks

Applying to the NSF-GRFP (or another fellowship) on a tight deadline?

We built a 7-week guide + timeline to get you from draft to submission. It’s not too late — you’ve got this! ✨

🔗 cientificolatino.com/apply-in-7-weeks

#NSFGRFP #GradSchool #Fellowship

STATES REQUIRING PRESCRIPTIONS FOR COVID-19 VACCINES CVS 34 states have no set limits, people can simply check a box when they make an appointment online to attest that they meet the FDA criteria, without a prescription or other documentation. 16 states require a prescription: Arizona, Colorado, Florida, Georgia, Kentucky, Louisiana, Maine, New York, North Carolina, Pennsylvania, Utah, Virginia and West Virginia, District of Columbia In Massachusetts, Nevada and New Mexico, CVS is not currently able to offer the COVID-19 as of yet. Walgreens 16 states require a prescription: Arizona, Colorado, Georgia, Indiana, Louisiana, Missouri, Montana, New Mexico, New York, Oregon, South Carolina, Utah, Virginia, Washington State, West Virginia and Wisconsin. Sabina Vohra-Miller unambiquous SCIENCE

New NYT article detailing new requirements for the COVID-19 vaccine across US. This is all very preliminary information, but I suggest if you live in these states that may require a prescription, you acquire a script from your family doctor asap.

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv.
🔗 doi.org/10.1101/2025...

We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer!

A short🧵

The Blythe Lab is growing! This summer we welcomed our first lab members: junior researcher Eamon Cole and postdoc Dr. Chantel Mastos.

Intracrine FFA4 signaling controls lipolysis at lipid droplets - Nature Chemical Biology An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on intracellular membranes associated with lipid d...

A new paper proposes an ‘intracrine’ signaling mechanism whereby a G protein-coupled receptor (FFA4) senses locally released fatty acids on intracellular membranes associated with lipid droplets to efficiently regulate lipolysis in adipocytes

www.nature.com/articles/s41...

Altered striatal dopamine regulation in ADGRL3 knockout mice Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupl...

🚨 New preprint alert! 🚨

Excited to share my latest work, now on bioRxiv:

“Altered striatal dopamine regulation in ADGRL3 knockout mice”

🔗 www.biorxiv.org/content/10.1...

How Trump’s D.E.I. Cuts Are Hurting Rural White Americans Too

“If you cut out these diversity measures, you're going to make science full of people that are very elite…Full of people who have grown up with a large amount of privilege, who were able to work in a lab in high school because their dad was a prof at Cornell.” 🧪

www.nytimes.com/2025/07/10/u...

image with handmade protest sign reading "NIH funding saves lives Creates Jobs" on left with call to action on right reading "Sign the Bethesda Declaration Support Letter - ADD YOUR NAME NOW!"

BOOM! Last nite we blew through the 20K mark and already @ 21K and counting.

Wanna feel what it feels like to stand together w/ 20,000+ other science stans supporting the heroes of the #BethesdaDeclaration?

CLICK to sign our #NIHLoveLetter here actionnetwork.org/forms/add-na...

#StandUpForScience

If you weren't angry enough already, here are the rates of non-competitive renewals through May.

4008 Non-competitive renewals were due to be funded in May.

The total funded was 99!

Some is due to terminations, but most is due to slow grant making due to DOGE review and other impediments.

1/2

The Trump administration is unlawfully seeking to destroy higher education in the United States. It now demands that we sacrifice our international students in the process. Universities cannot acquiesce to such extortion.

Astrocytes, hidden puppet masters of the brain Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species.

Learn more in a new #SciencePerspective: scim.ag/43iprSX

The NIH has dropped its research funding by $2.7 billion so far this year.

Cancer research funding has declined 31%.

And new NIH research grants fell to the lowest level in more than a decade.

Eye-opening findings in today's HELP committee minority report:
www.sanders.senate.gov/wp-content/u...

New report from Bernie Sanders, ranking member on the HELP committee

www.sanders.senate.gov/wp-content/u...

Lots of substance in here. Some highlights...

1/n

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration.

www.ascb.org/society-news...

NIH insiders: Trump is ‘dismantling and destroying everything’ After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding

Science article with perspectives from NIH insiders

www.science.org/content/arti...

1/n

Excited to share my first paper from my postdoc! In this study, we demonstrate that the mu opioid receptor produces a second wave of G protein activity on endosomes in a manner that doesn’t require receptor internalization. Check it out! www.pnas.org/doi/10.1073/...

Paradox of the Sub‐Plankton: Plausible Mechanisms and Open Problems Underlying Strain‐Level Diversity in Microbial Communities “Paradox of the sub-plankton: Plausible mechanisms and open problems underlying strain-level diversity in microbial communities” by Akshit Goyal* and Griffin Chure*. This work highlights the limitati...

Happy to have this out there! I had a lot of fun working with (and learning from) @akshitg.bsky.social on this mini-review on microdiversity in microbial populations and how current ecological theory fails to quantitatively explain the observations. doi.org/10.1111/1462...

Our Health ROI Explore how your tax dollars fund life‑saving medical research.

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival.

www.ourhealthroi.com

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...

Hey GPCRs, GRKs and Arrestins Scientists, I know these are troubling times but science makes us thrive. Check out the FASEB summer conference in Niagara Falls June 22-26 - great line of up outstanding speakers - we have a few slots open, register now. Abstracts due April 27th!