Jennifer A Miles, molecularrichard.bsky.social et al model the Aurora A-Bora-Plk1 ternary complex revealing how Bora bridges both kinases
#RefereedPreprint @reviewcommons.org

link.springer.com/article/10.1...

I wrote something about why giving negative feedback to your colleagues can be a bit like slaying vampires in The Lost Boys, or something like that.

quantixed.org/2025/04/23/f...

A masterclass in molecular imaging - too exciting for (this former NPC-phile's) words!

We prefer to savour our science, allowing each experiment and observation to simmer gently. Just like a slow-cooked dinner, we patiently wait for all the ingredients to combine, creating a tasty and hearty result. #slowscience

Very proud of the team that put this story together, especially co-first authors Selena Burgess and James Shelford, and thankful for all the enjoyable collaborations along the way. 5/n

Meanwhile, we discovered Affimers that block the interaction, and James in @steveroyle.bsky.social used them to find a novel function for this interaction in mitotic cells. 4/n

We showed that this helix binds TACC3 - but the structure of this complex eluded us until AlphaFold came along. And then we checked it and tested it to be confident in the model. 3/n

Mark Pfuhl's group determined the 3D structure of ch-TOG's TACC3 binding domain, finding a helix that dynamically associates with the rest of the domain. 2/n

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

AlphaFold was a game changer for this project. AF stories are a bit boring aren't they? It helped really us to make sense of our structural data. With some neat HDX-MS experiments, it all came together. A big thank you to all the authors, it's great to see it published! 3/n
doi.org/10.1083/jcb....