Regio- and Stereoselective Synthesis of Nitro-fatty Acids as NRF2 Pathway Activators Working under Ambient or Hypoxic Conditions Nitro-fatty acids (NO2FAs) are endogenously produced electrophiles and NRF2 activators with therapeutic potential. We developed a synthetic protocol combining a Henry reaction and base-promoted β-elim...

Thrilled to share our latest publication in J. Med. Chem. a new regio- and stereoselective method to make nitro-fatty acids that strongly activate the NRF2 pathway, even in low oxygen
Proud to collaborate with Perecko & Vacek group.
#MedicinalChemistry #NRF2 #DrugDevelopment #Synthesis

After 4.5 great years at Palacký University with Prof. Jiří Pospíšl as a Phd student and postdoc, I'm off to a new chapter.🤠 I am excited to join Prof. Thomas Böttcher’s lab at the University of Vienna where I will work on novel antibiotics.
Thanks to everyone for the support and good times.😁