Check out a new article out now from DDRU Director, M. Baumann & colleagues regarding transporter activities of prolintanes.

"Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences"

www.sciencedirect.com/science/arti...

Open access & out now in Psychopharm:

Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats

lnkd.in/ejeAXPPe

😎 collab w/ Psilera & the CFSRE

#DMT #psychedelics #pharmacology

Out now in Mol Psych -

The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects

nature.com/articles/s4138…

#psychedelics #pharmacology

This manuscript was chosen as the NIDA IRP paper of the month 😎🙏🙌

irp.nida.nih.gov/featured-pap...

Our pub describing an approach to quantify the head twitch response in mice from video recordings using the open-source machine learning-based toolkits DeepLabCut and SimBA is out now in ACS Pharm Trans Sci!

pubs.acs.org/doi/full/10....

#psychedelics #HTR #machinelearning

Psychedelic-like effects induced by 2,5-dimethoxy-4-iodoamphetamine, lysergic acid diethylamide, and psilocybin in male and female C57BL/6J mice - Psychopharmacology Rationale The head twitch response (HTR) is a spontaneously occurring behavior in mice that is increased in frequency by serotonergic psychedelics. The mouse HTR is often used as a proxy for psychedel...

Out now:

Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice

Check it out 👇

link.springer.com/article/10.1...

#psychedelics #HTR

Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis www.biorxiv.org/content/10.1101/2025.04....

Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis Serotonergic psychedelics induce the head twitch response (HTR) in mice, an index of serotonin (5-HT) 2A receptor (5-HT2A) agonism and a behavioral proxy for psychedelic effects in humans. Existing me...

Excited to announce our preprint using machine learning-based toolkits to quantify the head-twitch response in mice.

www.biorxiv.org/content/10.1...

Catch us on Friday at the virtual ISRP meeting!

www.isrpsych.org/conferences

12:10 PM - 12:25 PM EDT
9:10 AM - 9:25 AM PDT
Michael Baumann

3:15 PM - 3:30 PM EDT
12:15 PM - 12:30 PM PDT
Grant Glatfelter

#DMT #4MeOMiPT #psychedelics

Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs Abstract. Identification of N,N-dimethylpentylone (DMP) in counterfeit “Ecstasy” and “Molly” tablets poses risk to public health due to its adverse effects

Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs

doi.org/10.1093/jat/...

🚨 Save the Date! 🚨

I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐

✨ 24 presentations
✨ Register here today - www.isrpsych.org/store

#Psychedelics #PsychedelicResearch #ISRP2025

New pub in ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities & target profiles of #5MeODMT analogs

Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans.

pubs.acs.org/doi/full/10....

BPS Publications This brief review highlights some of the structure–activity relationships of classic serotonergic psychedelics. In particular, we discuss structural features of three chemotypes: phenethylamines, erg...

A recent review of 5-HT2A receptor SAR from Dr. Dave :)

Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid - Psychedelic Alpha In a quiet courtroom housed on the second floor of the Drug Enforcement Agency’s (DEA) Museum and Visitors Center in Arlington, Virginia, a legal battle is unfolding over the status of two key…

Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid

Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act.

psychedelicalpha.com/news/dispatc...

1) Drug discovery, medication development, new psychoactive substances, preclinical research

2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞

3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice 2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacol…

Check out our new publication on the pharmacological characterization of novel, "prophetic" nitazene synthetic #opioids - some of which were found to be more potent than #fentanyl!

www.sciencedirect.com/science/arti...

Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:

www.usonainstitute.org/updates/uson...

An LSD Comparison LSD itself, then, is not a natural product. And neither is the compound to the right of it - that's lisuride, which was synthesized in the early 1960s. A lot of work has been done on this chemical framework, and lisuride itself has been marketed as a drug over the years for migraine and several other indications. It has no hallucinogenic effects, though.

A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎

www.science.org/content/blog...

An LSD Comparison LSD itself, then, is not a natural product. And neither is the compound to the right of it - that's lisuride, which was synthesized in the early 1960s. A lot of work has been done on this chemical framework, and lisuride itself has been marketed as a drug over the years for migraine and several other indications. It has no hallucinogenic effects, though.

A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎

www.science.org/content/blog...

Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:

www.usonainstitute.org/updates/uson...

Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.

Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:

pubs.acs.org/doi/10.1021/...

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-metha... Molecular Psychiatry - Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

www.nature.com/articles/s41...

Excited to announce that I'm being promoted to a full-time federal employee in the DDRU to continue research on new psychoactive substances for the foreseeable future 🙌. Grateful for all of the support from NIDA IRP and Mike Baumann to make it possible 🙏

One glaring example: folks who run a reverse LD cycle run behavior during the dark phase in either normal lights or red light. This changes the LD cycle by breaking up the dark portion of the cycle with light exposure. This can induce circadian misalignment and impacts the results obtained.

The chronobiologist in me wants to highlight the importance of the Dictionary.com word of the day yesterday. Zeitgebers matter for all biological research.

Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.

Pioneering psychedelics researcher Roland Griffiths dies at 77 His work with psychedelic and mood-altering drugs generated immense scientific interest, helped patients suffering with depression and addiction

The important psychedelic and other research Roland lead at BPRU and his dedication to science will never be forgotten - RIP.

His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚

hub.jhu.edu/2023/10/18/r...

Finally made it to bluesy thanks to @alexkwan.bsky.social!

Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.