International collaborative effort to understand dengue and Zika | Imperial News | Imperial College London An international team launched the DeZi network to understand how the viruses spread, interact, and cause disease across Africa and Asia.

CIDRAP joins global partners in the DeZi Network — uniting 15+ countries to strengthen dengue & Zika surveillance and response across Africa and Asia.

🔗 www.imperial.ac.uk/news/269973/...

#GlobalHealth #Dengue #Zika

International collaborative effort to understand dengue and Zika | Imperial News | Imperial College London An international team launched the DeZi network to understand how the viruses spread, interact, and cause disease across Africa and Asia.

Today we're kickstarting the Dengue & Zika Immunology & Genomics Multi-Country (DeZi) Network funded by @wellcometrust.bsky.social with contributions from @temasek.bsky.social @neasg.bsky.social #UNITEDengue
@imperialcollegeldn.bsky.social @nfaria.bsky.social
www.imperial.ac.uk/news/269973/...

International collaborative effort to understand dengue and Zika | Imperial News | Imperial College London An international team launched the DeZi network to understand how the viruses spread, interact, and cause disease across Africa and Asia.

🔗 To learn more about #DeZI:
www.imperial.ac.uk/news/269973/...

🌍 #DeZi Partners span research institutions and public-health laboratories in more than 15 countries across #Africa, #Asia, and #LatinAmerica, working closely with UKHSA, Yale University, @who.int , and networks such as #UNITEDengue, #CREID, and #ARTIC2.0.

With its #open-access resources and policy engagement activities #DeZi will help countries integrate the surveillance of dengue, Zika, and other #mosquito-borne #viruses into routine national health systems, turning collaboration into capacity, and data into effective policymaking.

By combining innovation with equitable partnerships, #DeZi aims to:
• accelerate the adoption of improved diagnostics
• strengthen regional laboratory capacity and South–South collaborations
• enhance preparedness for future #arboviral #epidemics in a changing climate

🔬 #DeZi in brief:
Global initiative led by Imperial College London & Nuno R. Faria, supported by the #WellcomeTrust, Temasek Foundation & the National Environment Agency
It integrates #genomics, #serology & #modelling to map the burden, transmission, and evolution of dengue and Zika viruses.

Dear network, I’m pleased to announce the launch of hashtag#DeZi (Dengue and Zika Immunology and Genomics Multi-Country Network) – a global collaboration that I’m part of, bringing together leading teams across Africa, Asia, and the Americas to advance our understanding of dengue and Zika viruses. 🔬 DeZi in brief: DeZi is a global initiative led by Imperial College London and Nuno R. Faria and supported by the Wellcome Trust, Temasek Foundation and the National Environment Agency. It integrates genomics, serology, and modelling to map the burden, transmission, and evolution of dengue and Zika viruses. By combining innovation with equitable partnerships, DeZi aims to: • accelerate the adoption of improved diagnostics • strengthen regional laboratory capacity and South–South collaborations • enhance preparedness for future arboviral epidemics in a changing climate With its open-access resources and policy engagement activities DeZi will help countries integrate the surveillance of dengue, Zika, and other mosquito-borne viruses into routine national health systems, turning collaboration into capacity, and data into effective policymaking. 🌍 Partners span research institutions and public-health laboratories in more than 15 countries across Africa, Asia, and Latin America, working closely with UKHSA, Yale University, WHO, and networks such as UNITEDengue, CREID, and ARTIC2.0.

I’m pleased to announce the launch of #DeZi ! a global collaboration funded by @wellcometrust.bsky.social and led by @imperialcollegeldn.bsky.social that brings together teams across Africa, Asia & the Americas to advance our understanding of #dengue & #Zika viruses

Thread DeZi in brief 👇

Love seeing this! and couldn’t help but smile spotting my 2 posters quietly photobombing in the back! ☺️

These findings suggest that certain ZIKV-cross-reactive anti-DENV antibodies, especially those capable of activating complement, may help reduce the risk of severe dengue.

Among the different antibody features we analyzed, complement-dependent virolysis using ZIKV virions stood out as the strongest correlate of protection against severe outcomes, including thrombocytopenia and plasma leakage.

We analyzed pre-infection plasma from Nicaraguan children who went on to develop either dengue fever or severe dengue (DHF/DSS) upon secondary DENV infection.

Anti-dengue virus antibodies that elicit complement-mediated lysis of Zika virion correlate with protection from severe dengue disease Dias et al. show that cross-reactive anti-dengue virus antibodies in pre-infection plasma that mediate complement-dependent virolysis of Zika virus correlate with protection from subsequent severe den...

𝐖𝐡𝐲 𝐝𝐨 𝐬𝐨𝐦𝐞 𝐩𝐞𝐨𝐩𝐥𝐞 𝐝𝐞𝐯𝐞𝐥𝐨𝐩 𝐬𝐞𝐯𝐞𝐫𝐞 𝐝𝐞𝐧𝐠𝐮𝐞 𝐰𝐡𝐢𝐥𝐞 𝐨𝐭𝐡𝐞𝐫𝐬 𝐝𝐨𝐧’𝐭 — 𝐞𝐯𝐞𝐧 𝐰𝐡𝐞𝐧 𝐢𝐧𝐟𝐞𝐜𝐭𝐞𝐝 𝐛𝐲 𝐭𝐡𝐞 𝐬𝐚𝐦𝐞 𝐯𝐢𝐫𝐮𝐬? In our latest paper in Cell Reports, we show that the answer may lie in pre-existing cross-reactive antibodies. www.cell.com/cell-reports...

🔍 𝐊𝐞𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 in comments

Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype Nature Communications - There is still a need to improve understanding of dengue-specific immunity. Here, by analyzing the antibody response in a pediatric cohort the authors show that the...

Check out our paper in @natcomms.nature.com !
We explored the link between pre-existing neutralizing antibody (nAb) titers and dengue disease protection & how different cell substrate and virus maturation state influences the measurement of nAb titers

rdcu.be/eOfXW

Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social