Tau drives cell specific functional isolation of the hippocampal formation A major challenge in understanding Alzheimer's disease is linking changes that occur across different biological scales. For example, how do changes in individual neurons build into widespread network...

New preprint from the lab that I'm very proud of! We found mutant tau can disconnect neurons from their networks by temporarily silencing a neuron's activity. This leads to breakdown in the coherent activity between the hippocampus and entorhinal cortex. www.biorxiv.org/content/10.1...

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.

Spent a lot of time troubleshooting IHC in cleared tissue. Definitely recommend doing something like this to speed up your troubleshooting if you’re looking at specific targets rather than putting all your eggs in the basket of a specific approach. elifesciences.org/articles/84112

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Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology Zwang et al. used two-photon microscopy to track neurofibrillary tangle (NFT) formation and neuron loss in model mice. They observed that neurons with NFTs died less frequently than neurons without NF...

Our team at MGH is looking to hire a research technician to help us follow up our recent study exploring the death of neurons related to tau pathology. Anyone interested please reach out to me. #ADRD #Alzheimer's #Neurodegeneration #EndAlz

www.cell.com/cell-reports...

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