Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD - Stem Cell Research & Therapy Background Intestinal epithelial stem cells (SCs) and their transit-amplifying (TA) progeny are critical for mucosal repair and regeneration. However, their behaviour under chronic inflammatory condit...

Very excited to share our recent findings on stem cell dynamics in chronic inflammation! We used a combination of bioinformatics, mathematical modelling, and organoids to explore how stem cells adapt and respond in inflammation.

link.springer.com/article/10.1...

Had the pleasure of attending the London Gastrointestinal Organoid Network (LION) at the Francis Crick Institute 🦁🧬 Grateful to be part of a community pushing the frontiers of organoid research! A fantastic day of science and gut instincts #LION #Organoids

A sunlit path in a Pacific Northwest forest in the morning. A little fog remains, creating bright shafts of light that fall on the mossy trees, ferns, and the path itself as it stretches into the distance. Two children walk along the path, away from the camera, toward the sun.

#blueskyartshow #thejourney #pnw #forest #classicmono #photography

Intestinal #organoid goes rogue and flips polarity 🤯
@vucellimaging.bsky.social
#epithelial #cellbiology #microscopy

O is for #organoid

@vucellimaging.bsky.social
#microscopy #epithelial #cellbiology

#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d

T cell mediated impairment of epithelial integrity in Crohn's disease T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn's disease (C...

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...

Hi, I would like to join :)

In an age of info overload, are we well informed or just misinformed? It’s crucial for scientists to communicate their findings clearly and effectively to everyone, not just their peers. Scientific literacy will promote a society that values evidence over hearsay.
#StandingUpForScience Workshop

Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells A revised model of the cellular hierarchy during intestinal epithelial regeneration is presented, with the identification of multi-potent intestinal stem cells in the upper crypt zone. These cells are...

Two studies report that upper crypt progenitor cells are responsible for #intestinal epithelial regeneration and restoration of homeostasis and not LGR5+ stem cells, particularly after injury.
1. www.cell.com/cell/fulltex...
2. www.cell.com/cell/fulltex...

#StemCells #Gut 🧫