Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule The druggability of intrinsically disordered regions.

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

We are open for novel NMR projects and users!

Our biomolecular NMR expertise:
✅ Drug discovery (fragments & biologics)
✅ Intrinsically Disordered Proteins (IDPs)

Let’s get to work!
👉 tuit.cat/i9V81

#ICTSNews #IntegrativeStructuralBiology #NMR #NMRChat

Workshop: Integrative Structural Biology in the new Instruct-ES.

Dr. Borja Mateos, from the University of Barcelona, presents the CCiTUB state-of-the-art high-field NMR services available through the European Infraestructure Instruct-ERIC.

🆕 The #CCiTUB participate at the Instruct-ES Workshop celebrating the expansion of @instruct-eric.bsky.social! 🔬

Dr. @borjaml.bsky.social @ub.edu introduced our high-field NMR services.

Helping to build a community combining talent & tech to tackle modern biology big questions 🧬✨

🔗 tuit.cat/a3FGV

Primera trobada de responsables de Serveis Cientificotècnics (SCT) d'universitats catalanes.

🆕 Els #CCiTUB @ub.edu han acollit la primera trobada de responsables de Serveis Cientificotècnics (SCT) d' #universitats catalanes amb l'objectiu de crear un espai estable de coordinació a escala catalana i enfortir els serveis de suport a la #recerca.

🔗 tuit.cat/85S6t

Looking forward to host Luca!!! Join us to learn about the perfect tandem of NMR and glycobiology

Calling researchers in Spain!

Don't miss out on the Instruct-ES Workshop, the first meeting of the expanded Spanish Centre in Instruct-ERIC

Find out all about the technologies and latest research taking place at Instruct Centre Spain - register here 👇

instruct-eric.org/events/integ...

Senior Scientist - Wien, Österreich job with University of Vienna | 12849256 At the University of Vienna almost 11,000 personalities work together towards answering the big questions of the future. Around 7,700 of them do re...

Senior Scientist to join the NMR Centre and the Institute of Organic Chemistry, University of Vienna, Austria, extensive hands-on experience with NMR, EPR, DNP spectrometers, will oversee the operations of the advanced NMR core facility www.nature.com/naturecareer... #NMRjobs #NMRchat 🧲

Happy to contribute to this work!

Per Joan Massagué, els bons mentors han de reunir diverses qualitats, que es poden resumir en l’acrònim ICECRAM

#InauguracióUPF

Tales of teaching and teamwork - Nature Reviews Chemistry Ahead of her 75th birthday, Jane Clarke discussed her life in science, including her career change from school science teacher to protein folding researcher.

✨ Couldn’t agree more with Jane Clark’s words on life and science culture! And now… "back to kinetics and mechanisms again!"

Tales of teaching and teamwork | Nature Reviews Chemistry share.google/gtk7OPl6Rmbs...

NMR TITAN user survey This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...

I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat

Concesión de los Premios RSEQ 2025 – RSEQ Concedidos los Premios de la Real Sociedad Española de Química en su edición 2025.

Happy to share that Javier has been awarded the 2025 RSEQ “Young Researchers” Prize (Postdoctoral category).
We are grateful to the Governing Board for this recognition, which supports our work in organic synthesis and catalysis at @univie.ac.at

rseq.org/concesion-de...

So looking forward to this !

Open Positions 2025 Open Positions 2025

🚨 PhD Opportunity Alert! Repost appreciated!🔁

A fully funded PhD position is available in the Mateos Group at the University of Vienna!

🔹 Up to 4y of funding
🔹 Application deadline: April 21, 2025
👉 More info: doschem.univie.ac.at/application/...

#PhDPosition #Chemistry #Catalysis (1/4)

International Manuel Rico NMR School – GERMN Throughout its editions, this well­established course organized by the specialized Nuclear Magnetic Resonance (NMR) group of the RSEQ (GERMN) has become an excellent platform for improving the underst...

The Specialised Group of NMR of the Spanish Royal Society of Chemistry (GERMN-RSEQ) is pleased to announce the XVI International Manuel Rico NMR School.
#NMRchat
🗓️1st to 6th June 2025
⛰️Jaca (Spain)
germn.rseq.org/actividades1...

A fast sample shuttle to couple high and low magnetic fields. Applications to high-resolution relaxometry Abstract. Combining high-field high-resolution NMR with an evolution of spin systems at low magnetic field offers many opportunities for the investigation of molecular motions, hyperpolarization and t...

Rocket science alert 🚀!
Check out our latest preprint describing the new sample shuttle developed by @brukercorporation.bsky.social with our friends at @cerm-cirmmp.bsky.social and us. With support from @ec.europa.eu and @agencerecherche.bsky.social #NMRChat #chemsky

Figure from the paper that illustrates the approach of probing the transition state for amyloid growth by experiments and simulations

How do proteins mis-fold?

Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth

doi.org/10.1038/s415...

A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms Gustafson et al. identify a cis/trans isomerization switch in the BMAL1 transactivation domain that controls circadian rhythms. Conformationally locking the switch or inhibiting prolyl isomerases influences circadian period to suggest that slow protein dynamics play a role in timekeeping.

Always fun to read this one:
www.cell.com/molecular-ce...

From Weak Interactions to Strong Affinity: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis Understanding weak interactions in protein-ligand complexes is essential for advancing drug design. Here, we combine experimental and quantum mechanical approaches to study the streptavidin-biotin com...

📢 New preprint! 📄

Deciphering the molecular forces behind the exceptional binding affinity of the streptavidin-biotin complex via NMR and QM.

🔍 Check it out: www.biorxiv.org/content/10.1...

#StructuralBiology #NMR #ComputationalChemistry #DrugDiscovery

Tips on How to Write ‘Good’
#Matter

PDF download
www.cell.com/action/showP...

Hidden water’s influence on rhodopsin activation Structural biology relies on several powerful techniques, but these tend to be limited in their ability to characterize protein fluctuations and mobility. Overreliance on structural approaches can lead to omission of critical information regarding biological function. Currently there is a need for complementary biophysical methods to visualize these mobile aspects of protein function. Here, we review hydrostatic and osmotic pressure-based techniques to address this shortcoming for the paradigm of rhodopsin.

This review focuses on the importance of disordered water molecules in protein structures and discusses currently established methods of measuring the hydration states of proteins, their applications, and limitations. ow.ly/wknc50UtrIN

Universidades: Madrid y Catalunya, por Andreu Mas-Colell La Comunidad de Madrid, poco amiga de las universidades públicas, está desplegando una política favorable a la creación y expansión de universidades privadas. En

Universidades: Madrid y Catalunya
www.lavanguardia.com/opinion/2024...
Mas-Colell sobre el “trilema” de la universidad: demanda futura, restringir expansión privada, costes crecientes.
Su solución: Permitir a la universidad pública crear entes de derecho privado bajo su control.
Muy interesante.

1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field

Full room today to see Albert' (from @benlehner.bsky.social lab at @crg.eu ) work! Really insightful datasets!

Our work on how CPEB4 mis-splicing leads to its aggregation in autism spectrum disorder is now published in Nature.

rdcu.be/d2qjW

I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.

🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed.

💊The study opens new avenues for the development of targeted treatments for autism.

📰 Nature @natureportfolio.bsky.social

✍️ Carla Garcia-Cabau, Anna Bartomeu et al.

➡️ bit.ly/3BfEGlR

📌 DOI: 10.1038/s41586-024-08289-w

Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution in In Situ 1D NMR Reaction Monitoring In situ 1D NMR spectroscopic reaction monitoring allows detailed investigation of chemical kinetics and mechanism. Concentration versus time data are derived from a time series of NMR spectra. Each sp...

It's a little bit late, but I'm really excited for my first paper! For reaction monitoring by NMR, signal-averaging can be applied *after acquisition*, and results in better S/N *and* data density without the typical trade-off. pubs.acs.org/doi/10.1021/... #NMRchat #NMR @lloydjonesgroup.bsky.social

Closing ceremony of the #CrazyAboutBiomedicine Program: 25 secondary school students have completed a year of scientific immersion in #IRBBarcelona’s labs, working on innovative experiments under the mentorship of researchers from our centre.

➡️ bit.ly/415wmiY

🧪

This is a great opportunity to join our group as PhD student to investigate the role(s) of intrinsically disordered proteins in biomedicine !