Manchester Cell-Matrix Centre members

We'll always have matrix... Happy holidays to all our members and collaborators.

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship https://www.biorxiv.org/content/10.1101/2024.11.19.624265v1 The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. O

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship www.biorxiv.org/content/10.1101/2024.11....

Delighted to share our latest paper:

"The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response"

Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng

pubmed.ncbi.nlm.nih.gov/39515644/

Key findings 👇👇

TIL EZRC resources 🤗

For our 🦋: Tomorrow 3pm CET, grab your hot cocoa (ok coffee, let's be real) & let's get cozier with a talk by the amazing S. Ricard-Blum. All about computational biology, ECM protein interactions & the new vers of MatrixDB! Chair: @merrylabnotts.bsky.social Zoom link: t.co/mFDZASKYFH

Colourful #THEmeshwork logo

Welcome to Bsky @themeshwork.bsky.social - the platform for #ECMatrix lovers with the aim to connect Early Career Researchers around the world 🌍 Completely free to join!

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Was great fun to talk to @nephrosparks.bsky.social about digenic Alport syndrome. Give it a listen!

The antibodies don’t work! The race to rid labs of molecules that ruin experiments Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

"The antibodies don’t work!"

We, like many labs, have faced issues with bad antibodies cell.com/cell-stem-ce...

Great to see that some are tackling this problem head-on!

Read more about their solutions:
www.nature.com/articles/d41...

#ImmunoSky #Metaresearch #Openscience

Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation. https://www.biorxiv.org/content/10.1101/2024.11.15.623782v1 The extracellular matrix (ECM) forms the scaffold in which cells reside and interact. The compositio

Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation. www.biorxiv.org/content/10.1101/2024.11....

Collagen formation, function and role in kidney disease - Nature Reviews Nephrology Collagens are ubiquitously expressed and have been linked to a broad spectrum of disorders. Here, the authors discuss collagen subtypes and provide a summary of collagen disorders, fibrotic process an...

Our spotlight on collagen- formation, function & role in kidney disease is out now!

A wonderful collaboration with Moumita Barua & Vanessa De Gregorio

#ECMatrix
#Nephro

Cell-Matrix Centre
@fbmh-uom.bsky.social
@uoft.bsky.social

www.nature.com/articles/s41...

Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease Fibrosis is the cause of end-stage kidney failure in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The molecular and cellular mechanisms involved in fibrosis are complex and anti...

Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease www.biorxiv.org/content/10.1...

Let's gather the #ECMatrix community!!
go.bsky.app/47xREVJ

Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration https://www.biorxiv.org/content/10.1101/2024.11.15.623835v1 Understanding how mechanical stimulation from exercise influences cellular responses during tissue r

Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration www.biorxiv.org/content/10.1101/2024.11....