How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions The brain constantly generates predictions based on one’s knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Her...

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...

Huntington's progression slowed by experimental gene therapy An experimental gene therapy slowed Huntington’s by up to 75 percent in a small clinical trial. While not a cure, it may give patients longer lives.

In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:

The joy.

One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...

Shana V. Stoddard: How to create an environment for all science students to succeed Grad student <b>Alyssa T. Paparella</b> talks with this computational biochemist about adjusting work styles and leaning on community

✨My first science feature is out in Chemical & Engineering News!✨

I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM.

Disabled scientists deserve visibility and celebration.

cen.acs.org/synthesis/me...

#DisabledInSTEM #SciComm #RepresentationMatters

Join us in Congratulating the 2025 ACNP Travel Award Class! 🙌🎉

In case you missed this yesterday…..

First paper from my lab @upenn.edu (open access) @ Biological Psychiatry w/ @emilyrperkins.bsky.social +@keananjoyner.bsky.social

We discuss the need to falsify theories of biology predicting syndromes vs. syndromes in ways that allow both to be true 🧵1/10

authors.elsevier.com/sd/article/S...

Finally getting to post the thread on this, and excited to force you all to read some of the new work from our group on trying to understand if traumatic stress might impact reactivity to basic stimuli.

Or, honestly, where we asked “what if we just flash a checkerboard at trauma survivors?” 1/🧵

Traumatic stress alters neural reactivity to visual stimulation - NPP—Digital Psychiatry and Neuroscience This study investigated if exposure to traumatic stress altered brain activity to basic visual stimulation. The authors found that recent trauma survivors showed altered activity within the visual cor...

🆕 in DPN from our EB member @nateurneuro.bsky.social, @brainstorm12.bsky.social & @irosso.bsky.social et al:

Traumatic stress alters neural reactivity to visual stimulation

www.nature.com/articles/s44...

Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators Posttraumatic stress disorder (PTSD) is a well-characterized psychiatric disorder that features changes in mood and arousal following traumatic events. Previous animal and human studies of social supp...

Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging www.biologicalpsychiatrycnni.org/article/S245...

@repauchincloss.bsky.social

California sets an example to follow. @warren.senate.gov @markey.senate.gov

The NIH budget is on a fast track to disaster An NIH insider explains what Republicans are likely to do next, and what we can do

This piece by an anonymous NIH insider spells it out:
*Slow science spending as much as possible, ignore existing commitments
*Present the failure to spend as a "savings"
*House GOP leadership will make cuts permanent with rescission/tax cut
donmoynihan.substack.com/p/the-nih-bu...

How delays in issuing NIH funds may create the appearance of a budget 'surplus' that becomes justification to cut the NIH budget. @statnews.com #neuroskyence

𝗛𝗼𝘄 𝘀𝗵𝗼𝘂𝗹𝗱 𝘄𝗲 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻𝗱 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝗮 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻'𝘀 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲?
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...

#TobRegSky #PedSky #MedSky #EpiSky #policysky #polisky #neuroskyence #neurosci #PainResearch #addictionsci 🧪🛟
Queen's University in Canada starts program to admit "doctoral students whose offers from top U.S. schools have been rescinded or who are reconsidering their acceptance to a U.S. school ..."

Please consider making a public comment opposing the possibility of making NIH directors, program officers, and other staff (e.g. SRO, GMS) political appointees. This only took me ~90 seconds. Please repost. Thanks 👍

Acting Institute Directors named at NIH

Jeffrey Taubenberger, Ph.D. NIAID (Influenza)

Carolyn Hutter, Ph.D. NHGRI (Genetics, epidemiology)

Alison Cernich, Ph.D. NICHD (Rehab medicine)

Monica Webb Hooper, Ph.D. NIMHD (Cancer disparities)

Courtney Aklin, Ph.D. NINR (Clinical Psych)

1/n

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

We're hiring! The Shackman Lab is hiring a full-time postbac RA for the 2025-26 academic year. This is fabulous opportunity to learn, work, and play with us in the DMV before heading off to graduate school. shackmanlab.org/studycoordin...

Just heard @erc.europa.eu will increase funding for grantees relocating to #Europe. Researchers based in the US or elsewhere in the world, can apply for €1 million beyond the usual max amount to set up a lab or #research team, if scientifically justified. Now to be €2 million.

🧪 #grants #academic

Prevalence and Predictors of Nonresponse to Psychological Treatment for PTSD: A Meta‐Analysis Background. Although highly efficacious psychological treatments for posttraumatic stress disorder (PTSD) exist, there is evidence that first-line psychological treatment approaches leave a substanti...

Non-response to treatment is common for patients with PTSD. The lowest non-response rates is found for trauma-focused treatments, but even the non-response rates for these treatments is substantial. onlinelibrary.wiley.com/doi/10.1155/...

You look at science (or at least talk of it) as some sort of demoralizing invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated.

Rosalind Franklin (to father)

Bravo les Français, et en particulier l’Université d’Aix-Marseille. C’est bien pensé.

The administration is removing phone support for Soc Security recipients. Making it more difficult for seniors to get their checks. It’s a back door way to cut SS benefits. Horrific.

If you know anyone who is impacted, please help them get online to get their benefits approved

Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup. Background: Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorde...

In exciting news (for me), we demonstrate a structural covariance network of early visual cortex previously identified in recent trauma survivors is associated with PTSD symptoms in a mega-analysis of the ENIGMA-PTSD dataset.

www.medrxiv.org/content/10.1...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Exclusive: NIH appears to archive policy requiring female animals in studies Such a shift would “put us back in the dark ages in terms of our science,” says neuroscientist Anne Murphy, who helped to formulate the original policy.

Exclusive: NIH appears to archive policy requiring female animals in studies www.thetransmitter.org/policy/exclu...

With a slight delay, we turned this awesome paper into a comic 😍 Sneak peek below, check out the full version here: tinyurl.com/3jajehbn

@mathiasvschmidt.bsky.social @joeribordes.bsky.social
#neuroskyence #scicomm #wisskomm #sciart

#match2025 #APPIC For anyone who didn't match today, there are some WONDERFUL positions still available in Phase 2. Check us out!