The next iteration of O-MAP targeting genomic loci is now at eLife!!
DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social!
elifesciences.org/articles/102...
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
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This @zohrankmamdani.bsky.social video is absolutely INCREDIBLE. The numbers he cites, the strategy and results they produced — it’s the future. When have you heard *any* campaign talk about this, ever? (Video split in 2 to fit in Bluesky’s limits)
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
Jay, please stop gaslighting early career researchers.
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...
The fantastically successful NIGMS MIRA R35 "expired" on May 17, after the most recent deadline--these removals are the most aggressive attack on American science in the current series of devastating actions 🧪
Yes and yes. Also, don't sleep on Star Wars: Ran if doing more from Kurosawa
🤩
And this is why hate will never win.
A screenshot of the termination notice showing "Outstanding Investigator Grants"
A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
On a Nature news article reporting that NIH planned to suspend subawards for foreign collaborations: “No, that’s false. There’s going to be a policy on tracking subawards. The NIH and the government should be able to see where the money’s going.” “I’m really uncomfortable with this conversation, because you’re like, actually spreading rumors that you don’t know anything about. … Nature also is spreading rumors. Halt foreign collaborations, that’s not true.” “We’re working on the policy, Jocelyn. You shouldn’t be reporting rumors. I know there’s leaks all over here, but the leaks don’t actually reflect what’s happening. Don’t write about rumors. It actually makes the things that you and I care about worse. Like it spreads panic.” Later that day, NIH released a policy that halted future subawards to foreign scientists and said they will need to apply directly for money under a system still in development.
With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond.
Here's an inside look into how this story was reported. It was a weird one. 🧵
www.nature.com/articles/d41...
A letter from Jeremy Berg to NIH Director Jayanta Bhattacharya about the need to award grants promptly.
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
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THIS is what NIH funding means for real people, and why we can't lose it.
I sat down with Emily & her daughter Charlie to discuss how NIH-funded clinical trials at Seattle Children's led to a cure for Charlie's cancer.
This is why we have to speak up, this is who we're fighting for.
Hi, everyone! My name is Alex. I'm a microbiologist/cell biologist/biochemist, and I'm sharing some of my career biography today for #YoungScientistNetworking.
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ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
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Seattle protests.
New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General
First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process
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Excited to see CellCycleNet featured by @LSAjournal! CellCycleNet is a new 3D deep learning model that enables cell cycle staging using only a nuclear stain (DAPI), achieving 95% classification accuracy @oligopain.bsky.social @uwgenome.bsky.social
www.life-science-alliance.org/content/8/6/...
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants.
This is an unlawful attack on scientific progress that puts lives at risk.
If the goal was to decimate U.S. leadership in biomedical innovation & fire scientists developing cutting-edge treatments—the Trump Administration is succeeding.
Trump & Elon are setting America back decades, undercutting research to discover lifesaving cures.
It's inexcusable.
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc.
Anyone in Iowa City that can offer more insight?
scienceimpacts.org
H/T to Prathima !
These are training grants. 🚨
The Trump administration has launched a war on students and young people studying science.
It’s a common thread. Trump is killing student fellowship grants at NIH and NSF, and is killing the NIH and CDC in-house fellows programs.
(around images of Jeff Bezos, Donald Trump, and Elon Musk) After-tax incomes for everyone except the top 1% will go down under Trump's economic plan. Billionaires get richer. 99% of Americans lose money.
