Focus Issue: Trained Immunity Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.

2/ Our brand new Focus Issue brings together some of the latest research in trained immunity.

Explore it all today 👇
elifesciences.org/collections/...

Triggers of trained immunity across all tissues.

1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
buff.ly/NHdWyKS

Pleased to share our review l.
Thank you @payalyokota.bsky.social

Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics TRPV1+ neurons facilitate host survival from flu infection by controlling viral spread, myeloid cell responses, and immunopathology.

Check out this beautiful paper from Isaac Chiu lab, with some contributions from our lab.

www.science.org/doi/10.1126/...

@khannakm.bsky.social

Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

Brilliant and paradigm shaking new story by Vishwa Deep Dixit's team out this month @naturemetabolism.bsky.social -"Cysteine depletion triggers adipose tissue thermogenesis and weight loss". Congratulations to Deep, Aileen and the entire team on this important work. 🤯
www.nature.com/articles/s42...

Check out the latest review article from #TeamKhanna superstars Eduardo Bernier and recent alumni Dr. Eric Bartnicki.

Macrophages: sentinels, warriors, and healers
Free Link:
academic.oup.com/hmg/advance-...

@khannakm.bsky.social

Macrophages: sentinels, warriors, and healers Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur

Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:academic.oup.com/hmg/article-abstract/doi...

academic.oup.com/hmg/advance-...

Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

#WeAreWhatWeEat! #EveryCellIsAnImmuneCell! Dixit, Lee &co show @natmetabolism.nature.com that caloric restriction depletes cysteines, driving weight loss & browning of white adipose tissue via sympathetic nervous system-derived noradrenaline signaling, reversing metabolic inflammation in obese mice!

Thank you for highlighting this preview of our work by Drs. Rothlin and Ghosh at @yalesph.bsky.social.

What a delight to see this.. 🥹

@khannakm.bsky.social @yeungadventures.bsky.social

May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

Indeed! Great job Mimi!

Congratulations John!

Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19 NYU Langone study shows a type of immune cell in the lungs may help prevent inflammation from spiraling out of control during COVID-19. Learn more.

🫁"Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19". Congrats @payalyokota.bsky.social, @khannakm.bsky.social, and colleagues!

nyulangone.org/news/lung-im...

Scientists fear Trump administration cuts to NIH could impact the health of Americans for generations Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans' health.

www.cbsnews.com/news/scienti...

I wish this was sensationalized or exaggerated - but the impact on US biomedical research outlined in this report is, unfortunately, very much real.

NIH | Sunday on 60 Minutes YouTube video by 60 Minutes

Please watch tonight’s important episode of “60 minutes” focused on the impacts of reductions to the NIH budget and workforce featuring a UW Immunology graduate student.

www.youtube.com/watch?v=noyS...

Thank you Sergei

Fantastic and important work @ikinglab.bsky.social

Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues

Thanks Brian!

Host defense involves both resistance and disease tolerance, a concept elegantly demonstrated in lung viral infection by @yeungadventures.bsky.social @payalyokota.bsky.social @khannakm.bsky.social and colleagues. Spread the word!!

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

So cool!

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated macrophages (NAMs) in mitigating SARS-CoV-2 pathogenesis. NAMs regulate viral spread and inflammation through type I interferon signaling, revealing their critical function in disease tolerance and potential as therapeutic targets for respiratory viral infections.

Online now: Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...