Excited to share recent work led by the Seiradake lab, for which we have contributed, published in Nature Communications:
“Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.”
www.nature.com/articles/s41...
Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was.
This is how it all started...
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Excited to announce this postdoc position at the intersection of experiment and computation for time-resolved cryo-EM! It's a collaboration between the Enchev group at the Crick and myself and @pilarcossio.bsky.social at the Flatiron Institute! Plz share.
crick.wd3.myworkdayjobs.com/External/job...
Finding a cure for #Parkinsons Disease will require funding of basic research to increase understanding. One study, performed by the group of Professor E Yvonne Jones, investigated the structure of the protein Frizzled3, thought to play a role in Parkinson’s.
Postdoc position: Computational Biophysics of Disordered Proteins, Lindorff-Larsen group, University of Copenhagen, Denmark https://tinyurl.com/REWIRE-PD Deadline May 3rd, 2026
We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins
We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social
tinyurl.com/REWIRE-PD
🚀 Introducing the LUMEN White Label Platform (Alpha)
We’re excited to share a major milestone for LUMEN: the release of the alpha version of our White Label discovery platform. wlp.netseven.work (temporary URL) 🔍This is just the start — LUMEN is working toward a full open-source release this year.
For all interested in glycolipids. Interesting review about synthesis of GSLs, their role in physiology, pathology, endocytosis/trafficking/secretion and GSL-targeting strategies in drug design.
tinyurl.com/bdpy9zub
#glycotime
It's a win for Toulouse!
@robincorey.bsky.social @ianofbristol.bsky.social good luck! Toulouse vs Bristol 🏉
latest #molstar publication pulling all details on its graphics engine together - lots of pretty pictures
with Gianluca Tomasello (@proteinimaging.bsky.social), Áron Samuel Kovács, @ludovicautin.bsky.social, David Sehnal
pmc.ncbi.nlm.nih.gov/articles/PMC...
Trying some procedural animation for #molstar. Not real in any sense but intended to convey dynamics.
github.com/molstar/mols...
This was fun to pull together! Such a fast moving field!
‼️ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!
.. And an heartfelt thank you to all the speakers and participants who made this event truly special.
I would like to thank my co-organizers, Célia Plisson, @sonyahanson.bsky.social , and @bonomimax.bsky.social, for their collaboration and energy throughout this journey.
A special thanks as well to G. Juffroy at the @cbitoulouse.bsky.social in handling all the practical aspects of the event.
After three inspiring days filled with excellent science our @cecamevents.bsky.social meeting has come to an end!
We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...
March 24, 1882 Koch identified the #TB bacterium, launching the breakthroughs that eventually made #tuberculosis treatable. Today TB remains a leading infectious killer, driven by #AMR, gaps in diagnosis and care +social factors: poverty, undernutrition, diabetes, and HIV
www.who.int/campaigns/wo...
I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...
We are launching something very exciting next week!! If you are a lipid researcher, love lipids or might need a lipid collaborator in the future, please follow and share!
#lipids #lipidresearch
Top: Diagram showing Type VI Secretion System–mediated interbacterial antagonism integrated with a computational pipeline used to identify and classify previously uncharacterized antibacterial effector families. Created in BioRender. Bayer-Santos, E. (2026). Bottom left: E. coli toxicity assay. Serial dilutions of E. coli carrying pBRA and pEXT22 constructs. Bottom right: Time-lapse microscopy of E. coli carrying pBRA SP-Tox-Act1 grown on repressed or induced conditions. Scale bar: 5 µm. Timestamps in hours and minutes.
During microbial warfare, #bacteria deploy toxins to inhibit or kill competitors. @ebayersantos.bsky.social &co reveal lipid-targeting #antibacterial #toxins & novel toxin domains within #Salmonella T6SS effectors, broadening known toxin enzymatic diversity @plosbiology.org 🧪 plos.io/40zTyEP
When it rains myco publications in pours myco publications!
Now out in PNAS tinyurl.com/2a6833n4
When @zestytoast.bsky.social accidentally isolated the long-chain acyl-CoA carboxylase, we quickly realized we were looking at a fascinating machine essential for building the mycobacterial membrane...
Looking forward welcoming next week all the participants of the CECAM workshop organized with @sonyahanson.bsky.social , Celia Plisson-Chastang, and @bonomimax.bsky.social at the Museum of Toulouse
Full program: www.cecam.org/workshop-det...
📖🔓 Promue depuis bientôt dix ans, la science ouverte s’est durablement implantée. Loin de se cantonner à la seule question des données et publications scientifiques, elle a transformé en profondeur les pratiques de recherche. Explications ⤵️
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Figure 1. Cryo-EM of abundant protein complexes in native membranes.
Figure 2. Cryo-EM of membrane proteins in vesicles.
Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.
Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.
I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN pubmed.ncbi.nlm.nih.gov/41755834/ #cryoEM
Now published in JCTC pubs.acs.org/doi/10.1021/... Works also for ENM!
Amazing PhD @cristianrocharoa.bsky.social
and I have collected our thoughts and questions (many!) on lipid scramblases in this review:
www.sciencedirect.com/science/arti...
If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!
