How can we learn tissue mechanics directly from cell patterns and images?

In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors.

shorturl.at/PUzT0
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Congratulations Gaëlle !

I'm happy to present our new tool, EpiCure, a napari plugin to ease correction of segmentation and tracking of epithelia movies, developed in @devstempasteur.bsky.social

Happy to share the heroic effort of @gaellel.bsky.social to reduce our segmentation pain through EpiCure (Epithelial Curation), a napari plugin easing the curation of epithelial segmentation developed with several groups of @devstempasteur.bsky.social.
www.biorxiv.org/content/10.6...
See more 👇

Hello epithelia enthusiasts!

I’m @inesfournon.bsky.social and I study epithelial mechanics in sea anemones 🪼

Did you know epithelial cell extrusion had never been described outside bilaterian animals before? Well… not anymore 👀

Read ⬇️🧵1/9

Thanks to #Appose hackaton with @jytinevez.bsky.social, @ctrue.bsky.social, @nkiaru.bsky.social, @msphan.bsky.social, @strigaud.bsky.social, Carlos, Thomas and Julie, DeXtrusion can be **INSTALLED** and run to detect cell extrusions directly from Fiji 🤩! Appose is amazing

What determines the sharpness of cell fate boundaries in gradient-based patterning?

We quantified #transition #zone #widths (TZW) across seven progenitor domain boundaries spanning the entire dorsal-ventral axis of the developing #mouse #neural #tube.

Preprint: doi.org/10.64898/202...

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Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...

The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play!

www.biorxiv.org/content/10.1...

How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁

Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology

doi.org/10.1101/2025...

👇Thread 🧵(1/9)

Morphometry and mechanical instability at the onset of epithelial bladder cancer Nature Physics - Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are...

Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in
@naturephysics.bsky.social :
rdcu.be/d5rTP

#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling

Competitive recruitment for researcher CRCN 2025 - Inserm pro In 2025, Inserm is opening up 67 tenure positions (Researchers junior and senior), covering disciplines dedicated to biomedical research and human health. Registration deadline: January 20, 2025.

Inserm is opening up 67 tenure positions (Researchers junior and senior), covering disciplines dedicated to biomedical research and human health.
Deadline: January 20, 2025

pro.inserm.fr/rubriques/co...

Developmental delay ensures global tissue size robustness upon local induction of apoptosis The capacity of our tissues to cope with external and internal stress relies on the tight coupling between cell proliferation, cell growth and cell death. This coupling is assumed to be based on compe...

Wishing you all the best for 2025 ! ...and a little late thread on our recent preprint studying how tissue growth is affected by mild induction of apoptosis. Drosophila wing disc readjusts global tissue size by modulating dev. time without local proliferation boost.
www.biorxiv.org/content/10.1...

🌞 Eastern sessions: New this season! Happening bi-weekly on Wednesdays to better suit attendees in Eastern time zones. Explore the schedule for an exciting lineup of speakers and look for the ☀️ symbol in the flyers for individual sessions. [3/4]

Looking for a job still connected to acamedia and research ? Do you like interacting with a lot of people, outreach activity, organising scientific events ? Do you have good writing and organisation skills ? We may have a job for you👇 (permanent position)

emploi.pasteur.fr/offre-de-emp...

🙏RT

Scanning electron microscope image of a human trunk-like structure (left) and human embryo (right) false coloured for somites (magenta) and neural tube (gold).

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

Figure 1 (D) Transverse sections of hindbrain segment centre of r5 in WT embryo, representative of other hindbrain segments, at stages 20-42 hpf with HCR RNA-FISH for fgf20a (cyan), etv5b (magenta) and membrane markers EGFP-CAAX (white). Progenitors expressing etv5b are aligned with the position of fgf20a-expressing neurons, where the basal processes of these progenitors are adjacent to the signalling source. n≥8 per stage.

Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch

Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk:
https://doi.org/10.1242/dev.204256

🦈 🦈 Catshark embryo (S canicula) around stage 28 🦈🦈

Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
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I read « l’aveuglement » recently and I loved it, I was looking what to read next from that author! I’ll take the suggestion :)

Hello Bluesky 🦋
I’m excited to speak at next week’s VGZT! Please join in case you want to know more about my work on the metabolic control of germ layer proportions #devbio #metabolism #stemcellmodels @vgzt2021.bsky.social

Beautiful. I love the colour choice

Check out how #neuralcrest cells 🔬 migrate (animal= #zebrafish, white cells=sox10+, start=10 somites stage, anterior=top)

Great work by @omdrozdowski.bsky.social who found that the bubbly vertex model naturally leads to cell bulging and extrusion at topological (pentagonal) defects in curved epithelia. Read the preprint at arxiv.org/abs/2411.07141

You asked for it...

This looks amazing !

🚨Preprint alert 🚨Do you need a highly sensitive kinase biosensor? Want to multiplex multiple sensors or look at nanoscale activity architecture? Our far-red chemigenetic kinase biosensors are what you are looking for. Thanks to everyone involved! tinyurl.com/d36e2t4m

Wait! Do you have tortoise in the lab ?

Timely neurogenesis enables increased nuclear packing order during neuronal lamination https://www.biorxiv.org/content/10.1101/2024.11.12.623216v1 The coordination of cell proliferation, migration, and differentiation is crucial for organogenesis

Timely neurogenesis enables increased nuclear packing order during neuronal lamination www.biorxiv.org/content/10.1101/2024.11....

Hello! 👋 I’m Christopher, a reproductive biologist and group leader at IBDM, France 🇫🇷

My lab uses #LiveImaging to study how the dynamic #ovary makes healthy #eggs 🔬🥚

Here’s a video from my postdoc in the Schuh lab, where we visualised #ovulation live in isolated mouse follicles 💥

📄 bit.ly/3Ya8dEL