Immune cell ‘bloodhounds’ track cancer cells’ unique metabolic signatures, eliminate tumors in mice Immune cells engineered to sense metabolic byproducts secreted by cancer cells ‘follow their noses’ to migrate to and infiltrate solid tumors in mice in a Stanford Medicine study.

Researchers at Stanford Medicine are developing immune cells designed to better recognize and attack cancer — offering a new approach to cancer treatment. stan.md/4uOdMIK

A screenshot of a slide. The title is "Open access: death of a dream". On the left hand side is the title and abstract of a paper published in 2021 estimating the actual costs of publishing an academic paper as between $200 and $1000 dollars, with high-profile journals with high rejection rates being towards the upper end and $400 being the cost for an "average" paper. On the right is a table of glamour mags and their APCs: $11400 for Cell, $12850 for Nature and all the hybrid Nature XX journals, $7350 for Nature communications, $7170 for the Lancet and $7030 for Current Biology.

I'm writing a talk on the current problems with scientific publishing. It's getting harder and harder to avoid just screaming at the computer. Here's a typical slide 🧪

Happy to share this latest article from the Fan Yang group (Stanford), where microribbons were used as a bioink for 3D bioprinting.
Very grateful to have contributed by analyzing the printed materials :)

doi.org/10.1016/j.bi...

#3dprinting #biomaterials #chemsky 🧪👩‍🔬

Biorthogonal PEGylation of Hierarchical Porous Metal–Organic Frameworks as Robust, Functional Nanocarriers for Hemoglobin-Based Oxygen Delivery http://dx.doi.org/10.1021/jacs.5c10582

Play a little game and choose the right icon for each role in science.

Play our CRediT Roles icon game/survey, and help make scientific authorship clearer and more accessible!
creditsurvey.sciux.org

#OpenScience #ScienceUX

Presenting my project on Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels.

Sunset view at BMES 2025

I had a great time attending and presenting my work at #BMES2025 in San Diego. It was such a nice opportunity to talk about my and others' projects on bone tissue engineering. Thank you everyone for the great talks! 🧪👩‍🔬

Red vine leaves turned red on a wall/building in autumn

🍁 Beautiful autumn atmosphere at #DTU this morning

#Autumn
#Photography
#Nature
#Morninglight

Poster T37. Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels.

Excited to be attending #BMES2025!

I will be presenting my work on fabricating oxygen releasing scaffolds for bone tissue engineering in Friday's poster session (T37). Interested in targeting hypoxia, hemoglobin-based oxygen carriers, or bone TE? Please come say hi 😀

🧪👩‍🔬

Cartoon from the Nobel Assembly showing the three prize winners, their names, and “for their discoveries concerning peripheral immune tolerance.”

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

3 Conference Preparation Tips for Science and Tech Events In addition to making last-minute updates to your talk 👀 Update your LinkedIn profile before you go!Make it easy for new connections to find and follow your work.Make sure everything is current. Doubl...

What’s your #1 survival tip for scientific conference season? 👀

Mine: update LinkedIn, sponsor others, and do something fun off-site

Read more about why these 3 strategies work on the Thriving Ibis blog: www.thrivingibis.com/post/3-must-...

#AcademicSky #WomenInSTEM #WomenInTech #WomenInScience

Frontiers | Synthetic Biology in Pharmacology: Engineering Circuits and Cells for Therapeutics Synthetic biology, an interdisciplinary field blending principles from molecular biology, organic chemistry, computational modeling, and nanobiotechnology, f...

Excited to be a topic editor for:
Synthetic Biology in Pharmacology: Engineering Circuits and Cells for Therapeutics

We are seeking articles regarding:
- Artificial Cells for Drug Delivery
- Metabolic Engineering for Drug Production
- Synthetic Gene Circuits
tinyurl.com/38j4d6u4

🧪👩‍🔬#Chemsky

Nieuwe stap in 3D-printen: ook menselijk weefsel kan worden 'geprint' Onderzoekers van de Universiteit Utrecht zijn een stap dichter bij het 3D-bioprinten van organen. De nieuwe techniek genaamd GRACE kan door middel van kunstmatige intelligentie zelf meedenken en sugge...

Thanks nu.nl for featuring our recent research results on GRACE #bioprinting @natureportfolio.nature.com . Check out the "good news" section (a fitting home and anme!) of Nu . nl of today:

🇳🇱 www.nu.nl/goed-nieuws/...

@utrechtuniversity.bsky.social
#3dprinting

Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliv...

Scientists at the Wyss have created cellular "backpacks," disk-shaped nanoparticles that can stick to immune cells without being engulfed, and release a steady stream of cytokines into their "host" cells to keep them activated.

Some say that #MOF were discovered in 1900s, but this figure from 1760s clearly show a crystal structure of a MOF with inclusion in pores. Look - metal centers, linkers, guest molecules, all in!

#MOF #chemsky #BraggYourPattern reporting from Portugal

Position of flask on magnetic stirrers can drastically affect reproducibility of experiments Comprehensive examination reveals improper siting of reaction vessels can affect catalyst formation, alter nanoparticle formation and change yields

New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky

Instant assembly of collagen for tissue engineering and bioprinting (a) Video recording showing high-throughput micro-liter collagen disk fabrication. Red boxes mark the same location where a 5 μL collagen droplet was deposited at t = 0. Scale bar, 2 mm. (b) Reflectance confocal microscopy reveals pore sizes from the...

Instant assembly of collagen for tissue engineering and bioprinting
->Nature | More info from EcoSearch

Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues Organized cell architecture and dynamic forces are key for (re)creating native-like tissue function (e.g., contractile soft tissues). However, few studies have explored the combined effects of materia...

Great to work on this review with Miguel Castilho, @ruidomingues.bsky.social and colleagues - we outline methods to design responsive #biomaterials that enable fabrication of more complex multicellular systems:

www.cell.com/trends/biote...

#TissueEngineering

Not sure where to publish your research? Here are 7 bookmark-worthy tools that help you decide on the right target journal or repository for your research!

A thread. 🧵

#ScienceSky
#PhDSky
#Postdoc

Check out this recent article from @bioe-stanford.bsky.social‬ on donor variability and 3D culture models influence human mesenchymal stem cell differentiation!

Read more here: doi.org/10.1089/ten....

Artificial Oxygen Carriers Save Lives in Expanded Access... : American Journal of Therapeutics en conventional blood products are not available for transfusion yet the patient requires additional oxygen-carrying support, artificial oxygen carriers may be required. However, there are no such FDA...

Three new cases reported on using artificial oxygen carriers, by Dr Zhen Mei (UCLA, US).
HBOC-201 was successfully used on sickle cell disease patients as bridge therapy and/or as substitute for allogeneic blood transfusion.
doi.org/10.1097/MJT....

🧪 #MedSky #HBOCs

Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles Nature Communications - Nanoparticle biomolecular corona fingerprints vary with disease state. Here, the authors use integrated multi-omics to show that inflammatory disease dynamics alter corona...

Extremely excited to share our latest research in Nature Communications @naturecomms.bsky.social! We show that inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles. Congratulations to all authors!! rdcu.be/d68EH @umbaltimore.bsky.social

The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements, by Manasherob et al. Published in the Journal of Tranlational medicine, 2024. https://doi.org/10.1186/s12967-024-05866-5. Below: Schematic understanding of dormant infection (green) as an MPS-mediated IL17 response to biofilm inhibiting PMN recruitment and function when compared to patients with (red) or without (blue) and active infection.

Attended an interesting talk by Prof. Derek Amanatullah (Stanford Med), discussing dormant infections in joint replacements. Concl.: MPS-mediated response as biomarker enables better screening and patient prognosis.

doi.org/10.1186/s129...

#AcademicSky #MedSky 🧪
@stanfordmedicine.bsky.social

Fully agree with this piece 🧪
In the past, I've contacted a Prof that miscited my paper (we did do the research, just in another ref). No response..

I think the reason is the long process of corrections post publ. So, better to ignore. Wrong citations should be treated easier, it will help everyone

It shows that each approach has its adv/disadvantages, whether using stem cells or particle systems.
While I am more interested in the latter, it is good to follow all the progresses made in each approach. Knowing a clinical trial was done in 2022 shows great promise for artificial blood!

Interesting & short article about artificial blood in Aljazeera, focusing on lab-grown blood (the alternative to HBOCs /PFCs).
Also summarizes their main disadvantage: "producing lab-grown blood is currently much more expensive than using donated blood".

1/2
🧪 #chemsky

Another TissueTalk is online, this time with with Prof. Warren Grayson (John Hopkins U, US)🧪
www.youtube.com/watch?v=yNuK...

Gave a clear introduction to the use of scRNA-seq in deciphering cells’ expressions during bone regeneration. Looking forward to reading the article on this.

#biomaterials

Paper: Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases, by Mohanto et al. Published in Journal of Nanobiotechnology, 2025. https://doi.org/10.1186/s12951-024-03060-9 TOC shows the four discussed products: hemoglobin-, perfluorocarbon-, stem cell-, and micro/nanobubble-based oxygen carriers. For each product, various disease models are targeted. These include i.a. hemorrhagic shock, oxygen preservation, tumor hypoxia, respiratory failure, stroke, chronic hypoxia, and sickle cell crisis. Fig 9 shows the required goals for the perfect O2 carrier. Include i.a. efficient O2 release, extended half-life, innate to inflammatory system, and no acute or long-term toxicities.

New review paper on artificial O2 carriers by Mohanto et al (Shosun U, KR)🧪
-Products: Hb-, PFC-, stem cell-, bubble-based O2 carriers
-Targets incl: anemia, tumor hypoxia, hemor. shock, tissue regeneration, organ preservation
-Finishes with key considerations for future

doi.org/10.1186/s129...

Paint Our Research page on the Fan Yang Lab website. Showing the first three painings called: Tree of Life, Conversations, and the Crabs Cycle

Another way to showcase the group's research👩‍🎨🧪

www.fanyanggroup.com/paintourrese...
Visit the site to see all 14 paintings (and maybe more to come!)
#AcademicSky