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To learn about

➡️ Dynamics of immunological tissue architecture in the human gut ⬅️

by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se
@kawresearch.bsky.social @remeseiro-lab.bsky.social

REGISTER NOW!
www.trippus.net/summerschool...

Postdoctoral position (scholarship) in metabolic-epigenetic interplay | Karl Carlström 📣 📣 📣 Job alert!!! Join us at Karolinska Institutet We are looking for a postdoc to the Carlström lab curious to dissect metabolic and epigenetic interplay using iPSCs and animal models coupled with...

🚨🚨🚨Job alert
We are looking for postdoc joining our lab. If you are interested in subcellular distribution of proteins using iPSC and animal models in combination with leading genome engineering tools, check this add out!!
🧠🧬🔬🧫💊

www.linkedin.com/posts/karl-c...

KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...

Latest form GCB lab!! Great work Muk!!🎉🎉🎉

Illustration of CAR-T cells that attack cancer cells. Image: Getty Images

A study published in @nature.com today presents a new method that makes it possible to generate CAR-T cells inside the body. Several types of #cancer were treated in mice without the immune cells needing to be extracted and processed in a laboratory 🧪 #immunotherapy news.ki.se/immune-cells...

Let me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...

Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye
youtu.be/naKrdCozPUg?...

We are hiring!

Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se.

If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out!
#hiring #sciencejob #STEMJobs

Congrats @patrikernfors.bsky.social!!! Our head of the MolNeuro unit at @ki.se, an inspiration to all of us!

How dopamine producing neurons arise in the developing brain In a new study from Karolinska Institutet, published in Nature Neuroscience, researchers have identified the neurogenic progenitor that give rise to dopaminergic neurons, the primary neurons affected ...

KI researchers have identified the neurogenic progenitor that gives rise to dopaminergic neurons – the primary neurons affected in #Parkinsons disease and essential for controlling movement. The study is published in @natneuro.nature.com 🧪 #neuroscience news.ki.se/how-dopamine...

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis: @cellpress.bsky.social www.cell.com/cell/fulltex...

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

Microglia checkpoints promote healthy myelin aging
Our new paper is out in Nature Neuroscience @natneuro.nature.com

www.nature.com/articles/s41...
🧵1/3

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.

First paper from the lab is now online
@natneuro.nature.com !
We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Generating long deletions across the genome with pooled paired prime editing screens Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.

🔗 biorxiv.org/content/10.1...

A short thread (by Juliane Weller)👇

We are looking for a Research Assistant with an interest in functional metabolic and epigenetic interplay in oligodendrocytes! To study this we apply a wide range of leading-edge technologies… | Kar... We are looking for a Research Assistant with an interest in functional metabolic and epigenetic interplay in oligodendrocytes! To study this we apply a wide range of leading-edge technologies, inclu...

We are hiring!!
Interested in applying various CRISPR editing approaches and cell profiling to address functional metabolic and epigenetic interplay in oligodendrocytes?!

Apply here 👇
www.linkedin.com/posts/karl-c...

Oligodendrocytes show early changes in multiple sclerosis A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...

A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...

Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...

with @pkukanja.bsky.social, @deckardw.bsky.social, among others

Interestingly we identified MS-associated SNPs to regulate oligodendrocyte proliferation and differentiation but also cytokine secretion!!
Great joint effort with @deckardw.bsky.social and remaining twitterless authors! Enjoy!

New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

Scientists map how the brain develops – and how it resolves inflammation Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience
@gocastelobranco.bsky.social
news.ki.se/scientists-m...

Latest from the lab in colab with @rongfan8.bsky.social

Låter som något äkta gnällisar skulle säga.

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...