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Posts by Peter E. DeWitt, Ph.D.

A digital illustration of a DNA double helix composed of glowing blue dots and lines, set against a dark, abstract background with interconnected lines and points.

A digital illustration of a DNA double helix composed of glowing blue dots and lines, set against a dark, abstract background with interconnected lines and points.

At CU Anschutz, our researchers are unlocking biological insights from incomplete datasets by providing guidelines to achieve near scRNA-seq accuracy in bulk deconvolution, enabling deeper insight into cell types and states within complex tissues ➡️ https://cudbmi.info/rna-guidelines-1

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NICOLAS RAAAAA

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pedbp Web Application: Visualize Pediatric Blood Pressure Percentiles (BPPs) How to use the pedbp web application as a convenient, reliable method to view pediatric blood pressure percentiles.

No code, no downloads—just insights. The pedbp app makes it easy to explore and visualize pediatric blood pressure percentiles (BPPs) in a user-friendly web app. @cuanschutz.bsky.social researchers designed this tool give consistent access to BPPs.

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National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data This cohort study assesses US incidence, mortality, and trends of sepsis in nonneonatal children using a Pediatric Sepsis Event (PSE) definition adapted from the 2024 Phoenix criteria for scalable ele...

A new Pediatric Sepsis Event (PSE) definition from CU Anschutz enables large-scale surveillance, shedding light on the true prevalence of pediatric sepsis and guiding better care and prevention nationwide.

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Opening Move ♟️

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Thanks!

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pedbp logo with a heart and blood pressure cuff in hexagonal format in the foreground, with other hexagonal logos of other software tools blurred and hazed in the background.

pedbp logo with a heart and blood pressure cuff in hexagonal format in the foreground, with other hexagonal logos of other software tools blurred and hazed in the background.

Pediatric blood pressure isn't the simple 120/80 'healthy' ceiling we learn for adults—it's a function of age, sex and more.

Led by @peteredewitt.bsky.social researchers @@cuanschutz.bsky.social developed pedbp: a tool for pediatric blood pressure percentiles. Learn more➡️ https://cudbmi.info/pedbp1

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Just practicing hand cut dovetails
#woodworking #handtools

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The Dogg is BARKING 🐶

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Graph titled "Annual trend in in-hospital mortality due to pediatric sepsis" from text@1. The graph shows mortality rates from 2016-2023. Three lines represent "Hospital-onset sepsis", "Overall sepsis", and "Community-onset sepsis".

Graph titled "Annual trend in in-hospital mortality due to pediatric sepsis" from text@1. The graph shows mortality rates from 2016-2023. Three lines represent "Hospital-onset sepsis", "Overall sepsis", and "Community-onset sepsis".

Among US #pediatric hospitalizations, an electronic health record–based definition identified #sepsis in 1.3% of encounters, with an in-hospital mortality rate of 10%.

#SCCM2026 #CriticalCare @sccmcriticalcare.bsky.social

ja.ma/4uKFHJy

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I was fortunate to be part of this project published on JAMA

ja.ma/4sY38xb

#pediatrics #sepsis #phoenix

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I made this dice tower for some friends. Four baffles inside the tower.

#woodworking

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First to 100. First to clinch.

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My abstract has been accepted for presentation at R/Medicine 2026.

I’ll be my R package, medicalcoder. www.peteredewitt.com/medicalcoder/

Thank you @rconsortium.bsky.social for putting on the conference!

#rstats #RMedicine #HealthInformatics #EHR #ClinicalResearch

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Diagram comparing longitudinal vs encounter-level comorbidity detection using ICD-10 codes across five patient encounters.

Top panel (Longitudinal): The patient initially has uncomplicated diabetes (E11.9). Later an encounter includes E11.22 and K72.10, indicating complex diabetes and severe liver disease. Using longitudinal logic, these conditions persist in later encounters even when only E11.9 appears, preserving severity and correctly flagging severe liver disease.

Bottom panel (Encounter-level): Each encounter is evaluated independently. Diabetes changes from uncomplicated → complex → back to uncomplicated when E11.9 reappears, and severe liver disease is never flagged because its code does not repeat.

Message: Ignoring patient history can downgrade severity or fail to identify comorbidities.

Diagram comparing longitudinal vs encounter-level comorbidity detection using ICD-10 codes across five patient encounters. Top panel (Longitudinal): The patient initially has uncomplicated diabetes (E11.9). Later an encounter includes E11.22 and K72.10, indicating complex diabetes and severe liver disease. Using longitudinal logic, these conditions persist in later encounters even when only E11.9 appears, preserving severity and correctly flagging severe liver disease. Bottom panel (Encounter-level): Each encounter is evaluated independently. Diabetes changes from uncomplicated → complex → back to uncomplicated when E11.9 reappears, and severe liver disease is never flagged because its code does not repeat. Message: Ignoring patient history can downgrade severity or fail to identify comorbidities.

Graphic showing how the medicalcoder R package controls comorbidity detection using the flag.method argument.

Left side: A sample dataset of patient encounters with variables patid, encid, icd10code, and poa, containing ICD-10 codes such as E11.9, K72.10, and E11.22.

Below the dataset are two example R code blocks calling medicalcoder::comorbidities():

flag.method = "current" (default), producing encounter-level comorbidity flags.

flag.method = "cumulative", producing patient-level flags that preserve comorbidities across encounters.

Right side: the medicalcoder hex logo and labels explaining that
current = encounter-level and cumulative = longitudinal history preserving.

The graphic illustrates that longitudinal comorbidity tracking in medicalcoder is controlled by a single argument.

Graphic showing how the medicalcoder R package controls comorbidity detection using the flag.method argument. Left side: A sample dataset of patient encounters with variables patid, encid, icd10code, and poa, containing ICD-10 codes such as E11.9, K72.10, and E11.22. Below the dataset are two example R code blocks calling medicalcoder::comorbidities(): flag.method = "current" (default), producing encounter-level comorbidity flags. flag.method = "cumulative", producing patient-level flags that preserve comorbidities across encounters. Right side: the medicalcoder hex logo and labels explaining that current = encounter-level and cumulative = longitudinal history preserving. The graphic illustrates that longitudinal comorbidity tracking in medicalcoder is controlled by a single argument.

Same ICD codes. Same patient. Different risk profiles.

Encounter-level comorbidity logic assumes ICD codes are re-reported every visit. They usually aren’t.

medicalcoder handles this

📦install.packages("medicalcoder")

#rstats #HealthInformatics #EHR #ClinicalResearch #RiskAdjustment #PublicHealth

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GUESS WHO’S BACK, BACK AGAIN 👀

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Thanks! I would love to hear what you think about the package after using it.

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CU Anschutz Makes Research Tools Available Worldwide The Department of Biomedical Informatics at CU Anschutz presents the Wall of Software: a growing gallery of open-source tools that support medical research

Read more about how DBMI built the Wall of Software and why it’s important for the research community: news.cuanschutz.edu/dbmi/wall-of...

6 months ago 0 1 0 0
A collage of diverse professional fields including genetics, digital technology with a person at a workstation, laboratory research, and medical review with text labeled "Softcare Almonds."

A collage of diverse professional fields including genetics, digital technology with a person at a workstation, laboratory research, and medical review with text labeled "Softcare Almonds."

Every breakthrough in 2025, from new ICU guidelines to building one of the most complete human genome maps, reflects the power of working together to improve lives. Discover the stories behind the impact ➡️ https://cudbmi.info/top-stories-2025-1

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a lot of medication blister packs in a pile containing medications of different color, size, and shape suggesting comprehensive medication management (CMM)

a lot of medication blister packs in a pile containing medications of different color, size, and shape suggesting comprehensive medication management (CMM)

Clinicians have a lot to consider for patient medications.

LLMs could support medication management, but medications pose unique challenges for these LLMs. @cuanschutz.bsky.social researchers developed a benchmark suite to evaluate these implementations: https://cudbmi.info/rx-llm-1

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phoenix package logo in hexagon among 'wall of software' where there are other hexagonal logos of software tools

phoenix package logo in hexagon among 'wall of software' where there are other hexagonal logos of software tools

phoenix supports researchers in implementing Phoenix & Phoenix-8 pediatric sepsis scoring—providing more reproducible research and findings that translate into better care over time. Learn more about the tool developed by researchers @cuanschutz.bsky.social➡️ https://cudbmi.info/phoenix-package-1

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📦 medicalcoder v0.8.0 is now on CRAN.

medicalcoder is a unified and longitudinally aware framework for ICD-based comorbidity assessment in #rstats

CRAN: cran.r-project.org/package=medi...

GitHub: github.com/dewittpe/med...

Website: peteredewitt.com/medicalcoder/

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