Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models - Nature Biotechnology Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models

Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models go.nature.com/4jgtKVA
rdcu.be/fa3yp

Breaking Through Barriers in Scientific Communication Three important communication frameworks for scientific startup founders

New blog post is live!

And this one is all about scientific communication

Checkout my overview of three valuable communication frameworks for scientific startup founders, including ABT

Thanks for reading!

livingbio.substack.com/p/breaking-t...

Over the last 30 years, biotechnology has been driven by the genome sequencing revolution. For the next decade, it will be artificial intelligence that leads the charge in translating the biological complexity that results from these data go.nature.com/4sLrzhi

Digging deeper into soil metagenomics: opportunities and limitations for studying the genomic potential of soil bacteria and archaea - Biology and Fertility of Soils Soil microbial ecology has been transformed by recent progress in sequencing and metagenomics, reshaping our understanding of soil microbial functions. This article examines how metagenomics can be us...

Metagenomics is great, but applying it to soil is... complicated 🦠⛏️ Our new Perspective Article is out, diving into the the opportunities and limitations of metagenomics to study soil bacteria and archaea
link.springer.com/article/10.1...

The DNA virome varies with human genes and environments - Nature Analyses of biobank data show that human variation such as age, sex and genetics, particularly at the major histocompatibility complex locus, is associated with viral abundance and supports a causal link between abundance of Epstein–Barr virus and Hodgkin’s lymphoma.

Nature research paper: The DNA virome varies with human genes and environments

go.nature.com/3Pyb5uC

QBEmax is a sequence-permuted and internally protected base editor - Nature Biotechnology A base editor designed using circular permutation reduces off-target effects while enhancing purity.

A base editor designed using circular permutation reduces off-target effects while enhancing purity go.nature.com/433euF5
rdcu.be/e9Cpn

Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease www.biorxiv.org/content/10.64898/2026.03...

Understanding AlphaGenome An overview of the complex and powerful genomic analysis model

🚨 New blog post is live ‼️

🔍 This time covering AlphaGenome, following its recent publication in Nature

🚀 This is a power yet complex model with a lot of potential

👀 Checkout my post for an overview that balances useful details without going into the weeds

livingbio.substack.com/p/understand...

See You at the February Biotech Meetup! The January meetup was a great way to kick off the new year! Let's keep the momentum going in February!

The January Twin Cities Biotech meetup was a ton of fun, and we are already ramping up for February!

Recap of the January event, as well as info on the next one, are available at the link below.

See you in February!

twincitiesbiotech.substack.com/p/see-you-at...

Lessons in Digital Innovation from Large Pharma to the Startup Ecosystem Five actionable insights from my recent presentation to the HITLAB Breakthrough Alliance

‼️ New year, new blog post!

🤔 What does it take to drive digital innovation in the life sciences?

💡 In this post, I cover some important lessons learned in digital innovation, as well as provide five key principles for success.

livingbio.substack.com/p/lessons-in...

Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st

🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...

Circular RNA Therapeutics: Current Investment Landscape & Recent Developments An overview of how circular RNA is being used to treat diseases, and what ventures are gaining traction

🚨 New blog post is live!

🦃 What better way is there to end a weekend (and for many of us, end the Thanksgiving holiday) than with a deep dive into circular RNA therapeutics?

livingbio.substack.com/p/circular-r...

Can the COVID-19 Vaccine Support Cancer Treatment? And what role could the microbiome be playing?

🚨 Another new blog post is live!

🦠 Can the COVID-19 vaccine support cancer treatment? And what role could the microbiome be playing?

👀 Check it out, including a lot of good resources for additional, detailed reading!

livingbio.substack.com/p/can-the-co...

cSplotch Summary Schematic

Big news: The Vicković Lab’s study on colon aging has been accepted by @natbiotech.nature.com! The team built a detailed atlas of aging colon tissue, using spatial transcriptomics + a new tool (cSplotch) to profile ~1,500 samples & 400k nuclei.
🔗 Read more: bit.ly/4hj3ry7
#SpatialTranscriptomics

I love the framing on those comics! Brilliant shelving!

New Month, New Biotech Networking Event! It's Happening In November!

November biotech networking is happening!

Be sure to mark your calendar to join the Twin Cities Biotech meetup group for another great evening.

October recap and November details/registration are available on our SubStack!

twincitiesbiotech.substack.com/p/new-month-...

Webpage screenshot of the Black Microbiologists Association job board. The page lists five academic job postings with institution names, locations, and posting dates. Listings include Hofstra University, NYU Langone Health, University of Chicago, Rice University, and University of British Columbia. The interface features a yellow and blue theme with top navigation links labeled About Us, Membership, Directory, Events, and Newsroom. Buttons for Donate, Contact Us, and Job Board are located in the upper right corner.

🔬 Microbiology job seekers 🧫 go to BMA Job Board to view open positions! Have a vacancy to fill? Posting instructions also available (scroll to bottom). blackinmicrobiology....

October Biotech is Happening Today! The autumn biotech season is in full swing!

October biotech is happening today in Minneapolis!

The autumn biotech season is in full swing, and now that Twin Cities Startup Week is behind us, it’s time for the Twin Cities Biotech meetup!

Checkout the link for details and registration!

twincitiesbiotech.substack.com/p/october-bi...

Hi everyone! Please share/repost for reach!

I’m building a really cool startup bootcamp program, and I’m figuring out who might be interested!

Topics will include fundraising, pilots, regulatory, etc. All medical.

Let me know if I should add you to my "first to know" list for when it goes live.

Ancient viral DNA in the human genome shapes early development Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.

Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development

go.nature.com/4nRJyA4

Is Scientific Writing a Journey or a Destination? What does it mean to write in the age of Large Language Models?

🚨 New blog post is live!

🤔 For this post, I reflected on recent publications asking the question: "What does it mean to write in the age of Large Language Models?"

👀 Check it out!

livingbio.substack.com/p/is-scienti...

Robot-assisted mapping of chemical reaction hyperspaces and networks - Nature A low-cost robotic platform using mainly optical detection to quantify yields of products and by-products allows the analysis of multidimensional chemical reaction hyperspaces and networks much faster than is possible by human chemists.

Nature research paper: Robot-assisted mapping of chemical reaction hyperspaces and networks

go.nature.com/3Iy42Pw

Aaand it's out! Meet MITE - the natural product tailoring enzyme database, just published in @narjournal.bsky.social! MITE DB captures the substrate- and reaction-specificity of tailoring enzymes, allowing to capture this information in a human- and machine-readable way! doi.org/10.1093/nar/...

🚨 Great fellowship opportunity for grad students!

🎓 A lot of folks are aware of the NSF GRFP but a lot less are aware of the similar DoD NDSEG.

💡 This competitive fellowship covers stipend and travel. It's a seriously great resource that not enough students know about.

ndseg.sysplus.com

Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts Bifidobacterium are beneficial members of the microbiota across animal hosts. Kujawska et al. demonstrate that bifidobacteria have likely co-evolved more closely with mammals, particularly primates, a...

Host-specific microbiome and genomic signatures in Bifidobacteriumreveal co-evolutionary and functional adaptations across diverse animal hosts

www.cell.com/cell-host-mi...

September Biotech Was Great! Now Get Ready For October! We had the September biotech networking event this week at Pryes Brewing Company.

We had a super fun September biotech meetup, and October is officially scheduled.

Here’s a link to the September recap and details for October:

twincitiesbiotech.substack.com/p/september-...

Building Successful Startups With Science & Adaptability A wide-ranging review of the Lean Startup framework

🚨 New blog post is live!

🤔 In this one I reflect on using science and adaptability to build successful startups and innovation programs (including those in large companies)!

✨ I had a lot of fun writing this one!

👀 Be sure to check it out!

livingbio.substack.com/p/building-s...

The Medical Alley Startup Meetup · Luma Meet the Medical Alley Startup community at the next monthly meetup! This is a casual event to meet cool people and talk about startups, research, medtech,…

To anyone in the Minneapolis Startup community, or anyone who wants to learn more about startups (especially students), there is a great meetup happening in September!

Details on the event page:

lu.ma/n40cxaem?tk=...

We had an awesome time at the Twin Cities Biotech meetup yesterday evening, this time at Pryes Brewing!

Be sure to signup for our meetup SubStack, which is the best way to keep updated on upcoming meetups!

twincitiesbiotech.substack.com

It's Time For August Biotech! It’s time for another great evening of summer biotech networking, this time at a great new location!

If anyone is looking for an awesome biotech networking event in Minnesota, be sure to checkout the Twin Cities biotech meetup!

We have our next event tomorrow! They are always a lot of fun!

twincitiesbiotech.substack.com/p/its-time-f...