A 3-year postdoc position in experimental immunology is available in our lab at Oslo University Hospital. If you know someone who is interested in B cells and autoimmunity, please spread the word! You can find more information and apply for the position here: 2411.webcruiter.no/Main2/Recrui...
We have two positions available in our lab at Oslo University Hospital: one PhD fellowship and one research technician. They are both related to autoantibodies in ulcerative colitis. Read more and apply here 👇
PhD:
2411.webcruiter.no/Main2/Recrui...
Technician:
2411.webcruiter.no/Main2/Recrui...
Collectively, our results suggest that systemic and gut IgA responses against bacteria originate from discrete anatomical sites with inductive sites in the upper aerodigestive tract likely playing a prominent role in generation of systemic IgA.
Notably, while IgA plasma cells in the bone marrow were almost exclusively of the IgA1 subclass, gut plasma cells showed an equal distribution between IgA1 and IgA2.
Further, by conducting scRNA-seq on isolated plasma cells from paired samples of bone marrow and gut, we map differences in gene expression and VDJ repertoire between the two compartments. We also identify shared clonotypes with reactivity to bacterial antigens.
By isolating bacteria from duodenal biopsies, we show that serum IgA recognizes certain species of the upper GI tract. IgA secreted from gut plasma cells on the other hand showed broader reactivity to different bacteria.
Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!
www.biorxiv.org/content/10.1...
I am looking for a PhD candidate to join my lab in Oslo! We are trying to understand the role of antigen-specific B cells in autoimmunity. See details and apply here 👇
2411.webcruiter.no/Main2/Recrui...
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Review @jimmunol.bsky.social
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...
Very happy to share our paper on enzyme-activating BCRs out now in @naturecomms.bsky.social 💥
BCRs can do more than just bind antigen! By boosting the activity of target enzymes, they enhance pathogenic T cell-B cell interactions in gluten-sensitive autoimmunity. rdcu.be/ecXfG
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease @cp-immunity.bsky.social
www.cell.com/immunity/ful...
Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....
This is great! I would love to join the party.
We created one of the largest antibody bottom-up proteomics datasets to query the impact of experimental and computational parameters on the reconstruction of antibody sequences. www.biorxiv.org/content/10.1... Brilliant work by @mchernigovskaya.bsky.social, Khang Le Quy and Igor Snapkow.