Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development The dynamics of antigen-specific Tfh responses during extended germinal center reactions are not well characterized. Marina-Zárate et al. show that vaccine-specific Tfh cells in the lymph node undergo...

www.cell.com/immunity/abs...

📖 Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development

#Tfh #germinalcenter

Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with MS activity.

www.science.org/doi/10.1126/...

“Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers”

#Tfr #Bcell #germinalcenter

Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center.
#Immunology #GerminalCenter
www.jjacobsenlab.com

Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape"
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...

Noncanonical functions of T follicular helper cells We review the roles TFH cells play in regulating immune responses and maintaining homeostasis that extend beyond helping B cell responses.

www.science.org/doi/10.1126/...

📖Noncanonical functions of T follicular helper cells
#Tfh #germinalcenter #Bcells

#SpatialTranscriptomics Stereo-seq 👤Carotid #Atherosclerosis

IntraPlaque #TertiaryLymphoidOrgan😎
CD138+ Plasma cells +diverse B cells

❎ #GerminalCenter
✅ #Lymphangiogenesis ✅#HEV
Col5A1+ fibroblast-like #SmoothMuscleCell as #LymphoidTissueOrganizer

#NatCVR 2025
www.nature.com/articles/s44...

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)

www.pnas.org/doi/10.1073/...

The cellular factors that impair the germinal center in advanced age Abstract. Long-lasting immunological memory is a core feature of the adaptive immune system that allows an organism to have a potent recall response to for

Terrific #ImmunoAgeing Review @jimmunol.bsky.social from
@linterman.bsky.social & friends @babrahaminst.bsky.social

"Thanks for the #Memory"

#Bcells #GerminalCenter #Immunity
#Infection #Vaccination #Antibodies

Longitudinal (over 6 wk) #2Photon imaging of 🐭Spleen #GerminalCenter remodeling (TLR7 agonist)

PMOXA-passivated abdominal imaging window ⏬immunogenicity

Treg/TFr ◀️Foxp3-DTR-GFP
Follicular dendritic cell◀️αCD35-iFluor-647
Collagen◀️SHG
Mφ◀️Autofluorescence

bioRxiv 2025
www.biorxiv.org/content/10.1...

Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome - Nature Communications Primary antiphospholipid syndrome (PAPS) is a clotting disorder attributed to autoreactive antibodies produced by B cells. Here the authors show, using single cell omics and B cell repertoire data, th...

www.nature.com/articles/s41...

#APS #Bcells #Germinalcenter
#Rheumsky #Immunosky

Nice little #GerminalCenter from a human tonsil for #FluorescenceFriday. 🔴CD23 🟢IgD 🔵Pax5

This week in #Science #Immunology: a fantastic paper on #GerminalCenter #BCell #immunometabolism! Check it out!

Choosing the right short talks is crucial for wrapping up our program. We are accepting abstracts until December 3 (11:59pm MST). Submit now for a chance to present in Monte Carlo this February! #KSBCells25 #adaptiveimmunity #germinalcenter youtu.be/W5naij8S6KQ @washumedicine.bsky.social