Using a mouse model of ischemic #stroke, Yun Hwa Choi, Zsuzsanna Fabry et al. show stroke-induced #lymphangiogenesis at the cribriform plate, suggesting increased drainage of the inflamed brain rupress.org/jem/article/...
📘 In #Neuroimmunology & #Neurodegeneration 2025: rupress.org/jem/collecti...
Brain #Lymphangiogenesis
VEGF-C in post #Stroke recovery
tMCAO🐭➡️
Transient (d3~14) lymphangiogenesis (⏫φ loop sprout) at Cribriform plate & Deep cervical lymph node
VEGF-C delivery via left CCA immediately⏫brain infrct
VEGFR3i MAZ51 i.p ⏬brain infarct
@jem.org 2025
rupress.org/jem/article/...
Heart #Lymphangiogenesis
LYVE1+ #LymphaticEndothelialCell KO🐭 of ACKR3, a decoy receptor for Adrenomedullin
post-Infarction
⏫survival
⏬Myocardial Edema
⏫peri-infarct #Lymphangiogenesis
siACKR3 #Hypoxia▶️
⏫LEC VE-cad junction
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Heart #Lymphangiogenesis
EphrinB2-mediated CDK5/ISL1 pathway
⏫🫀lymphangiogenesis
⏬ischemic injury by resolving post-MI inflammation
EphrinB2-CDK5-ISL1-VEGFR3
⏫ #LymphaticEndothelialCell proliferation migration➡️
Lymphatic clearance of Mφ
#SigTransductTargetTher 2025
www.nature.com/articles/s41...
Heart #Lymphangiogenesis
"Endogenous lymphangiogenesis⬇️TAC-induced 🫀 inflammation & perivascular fibrosis, delaying #HeartFailure development in C57BL/6 but not in Balb/c🐭"
anti-VEGFR3 Ab B6🐭
⏫perivasc fibrosis
⏫Mφ NK B
@hfpef-diva.bsky.social #CardiovascRes 2023
academic.oup.com/cardiovascre...
#LipidNanoparticle delivery of VEGFC mRNA to ⏫ #Lymphangiogenesis post- #MyocardialInfarction🐭
#PalmiticAcid PC DOTAP DMG-PEG2000 Cholesterol
Intramyocardial injection
⏫cardiac function
⏬fibrotic scar
⏬🫀water content
⏬myocardial stiffness
#Biomaterials 2025
www.sciencedirect.com/science/arti...
Heart #Lymphangiogenesis #Aging
#Exercise (6-wk voluntary wheel running) in aged🐭
⏫Lymphatic vessel density
⏬epicardial lymphatic φ
⏬peri-lymphatic immune cells
⏬peri-lymphatic fibrosis
⏫peri-lymphatic cardiomyocyte size
⏫cardiac lymph flow
#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...
🫀 #Lymphangiogenesis
#BranchedChainAminoAcid Catabolism
#HeartFailure
Prox1+ #LymphaticEndothelialCell BCKDK (kinase ⏬BCAA degradation) KO➡️
⏫Lymphangiogenesis
⏫Diastolic function
🐭HFpEF (L-NAME+HFD 12 wk)
Src-VEGFR3 axis
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
Fibroblasts⏫ #Lymphangiogenesis in transplanted heart🐭
BALB/c➡️C57BL/6J
Recipient pre-existing #LymphaticEndothelialCell➡️ 🫀allograft lymphangiogenesis
Ablation of Postn+ fibroblast (VEGFD Midline), or VEGFR3i➡️
⏬lymphangiogenesis
⏫allograft failure
#THNO 2024
www.thno.org/v14p1886.htm
#SpatialTranscriptomics Stereo-seq 👤Carotid #Atherosclerosis
IntraPlaque #TertiaryLymphoidOrgan😎
CD138+ Plasma cells +diverse B cells
❎ #GerminalCenter
✅ #Lymphangiogenesis ✅#HEV
Col5A1+ fibroblast-like #SmoothMuscleCell as #LymphoidTissueOrganizer
#NatCVR 2025
www.nature.com/articles/s44...
Neural Guidance of Lymphatics
#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell
Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis
Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
