#BranchedChainAminoAcid
Diabetic Atherosclerosis Calcification

#SpatialMetabolomics
#MassSpecImaging
Calcified👤tibial artery➡️
⏫BCAA metabolism

Propionyl-CoA, BCAA catabolic product▶️
H3K23 Propionylation
Smooth Muscle Cell Osteogenesis

SMC BCAT2 KO🐭

Research 2026
spj.science.org/doi/10.34133...

🫀 #Lymphangiogenesis
#BranchedChainAminoAcid Catabolism
#HeartFailure

Prox1+ #LymphaticEndothelialCell BCKDK (kinase ⏬BCAA degradation) KO➡️
⏫Lymphangiogenesis
⏫Diastolic function
🐭HFpEF (L-NAME+HFD 12 wk)

Src-VEGFR3 axis

#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....